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von Willebrand disease update: diagnostic and treatment dilemmas

Bolton-Maggs, P H B; Lillicrap, D; Goudemand, J and Berntorp, Erik LU (2008) In Haemophilia 14(s3). p.56-61
Abstract
Although von Willebrand disease (VWD) is now well-described, many facets of diagnosis and management continue to be debated. The diagnosis of type 1 disease can be difficult but recent genetic analyses help to distinguish many factors which can influence von Willebrand factor (VWF) levels and bleeding phenotype. Type 2 disease (functional abnormalities) includes a particularly interesting group of disorders with faulty binding between VWF and FVIIIC (Normandy) where treatment methods need careful consideration. Type 3 VWD is the most severe form of VWD and a new international study is underway to examine the use of prophylaxis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diagnosis, molecular genetics, prophylaxis study, VWD, VWD type 3, VWD Normandy
in
Haemophilia
volume
14
issue
s3
pages
56 - 61
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000256185300009
  • scopus:44249103993
ISSN
1351-8216
DOI
10.1111/j.1365-2516.2008.01713.x
language
English
LU publication?
yes
id
d89ee8dd-b013-4554-bfd1-41039b5f412e (old id 1202051)
date added to LUP
2008-09-15 14:05:46
date last changed
2017-10-01 03:40:06
@article{d89ee8dd-b013-4554-bfd1-41039b5f412e,
  abstract     = {Although von Willebrand disease (VWD) is now well-described, many facets of diagnosis and management continue to be debated. The diagnosis of type 1 disease can be difficult but recent genetic analyses help to distinguish many factors which can influence von Willebrand factor (VWF) levels and bleeding phenotype. Type 2 disease (functional abnormalities) includes a particularly interesting group of disorders with faulty binding between VWF and FVIIIC (Normandy) where treatment methods need careful consideration. Type 3 VWD is the most severe form of VWD and a new international study is underway to examine the use of prophylaxis.},
  author       = {Bolton-Maggs, P H B and Lillicrap, D and Goudemand, J and Berntorp, Erik},
  issn         = {1351-8216},
  keyword      = {diagnosis,molecular genetics,prophylaxis study,VWD,VWD type 3,VWD Normandy},
  language     = {eng},
  number       = {s3},
  pages        = {56--61},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {von Willebrand disease update: diagnostic and treatment dilemmas},
  url          = {http://dx.doi.org/10.1111/j.1365-2516.2008.01713.x},
  volume       = {14},
  year         = {2008},
}