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Alcohol consumption and the risk for prostate cancer in the European prospective investigation into cancer and nutrition

Rohrmann, Sabine; Linseisen, Jakob; Key, Timothy J; Jensen, Majken K; Overvad, Kim; Johnsen, Nina Fons; Tjonneland, Anne; Kaaks, Rudolf; Bergmann, Manuela M and Weikert, Cornelia, et al. (2008) In Cancer Epidemiology Biomarkers & Prevention 17(5). p.1282-1287
Abstract
Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height,... (More)
Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed >= 60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.081 compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n=537), the relative risks for >= 60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men. (Less)
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published
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Cancer Epidemiology Biomarkers & Prevention
volume
17
issue
5
pages
1282 - 1287
publisher
American Association for Cancer Research
external identifiers
  • wos:000256012800037
  • scopus:52649144323
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-07-2888
language
English
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yes
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9c1dcd9b-459e-42a7-8259-6a9b434fea99 (old id 1203463)
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2008-09-16 16:27:16
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2017-04-09 03:50:08
@article{9c1dcd9b-459e-42a7-8259-6a9b434fea99,
  abstract     = {Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed >= 60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.081 compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n=537), the relative risks for >= 60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.},
  author       = {Rohrmann, Sabine and Linseisen, Jakob and Key, Timothy J and Jensen, Majken K and Overvad, Kim and Johnsen, Nina Fons and Tjonneland, Anne and Kaaks, Rudolf and Bergmann, Manuela M and Weikert, Cornelia and Naska, Androniki and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Pala, Valeria and Sacerdote, Carlotta and Palli, Domenico and Tumino, Rosario and Bueno-de-Mesquita, H Bas and Vrieling, Alina and Gonzalez, Carlos A and Larranaga, Nerea and Navarro, Carmen and Barricarte, Aurelio and Quiros, J Ramon and Martinez-Garcia, Carmen and Hallmans, Göran and Stattin, Pär and Manjer, Jonas and Wirfält, Elisabet and Bingham, Sheila and Khaw, Key-Tee and Egevad, Lars and Ferrari, Pietro and Jenab, Mazda and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {5},
  pages        = {1282--1287},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Alcohol consumption and the risk for prostate cancer in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-07-2888},
  volume       = {17},
  year         = {2008},
}