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Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin

Sneddon, Alan A ; Tsofliou, Fotini ; Fyfe, Claire L ; Matheson, Ian ; Jackson, Diane M ; Horgan, Graham ; Sörhede Winzell, Maria LU ; Wahle, Klaus W J ; Ahrén, Bo LU and Williams, Lynda M (2008) In Obesity 16(5). p.1019-1024
Abstract
This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 20) and obese (BMI, 32.0 +/- 1.6 kg/m(2); n = 14) men participated in a double-blind placebo-controlled, randomized crossover study. Subjects received either 6 g/day control fat or 3 g/day CLA (50:50 cis-9, trans-11: trans-10, cis-12) and 3 g/day n-3 LC-PUFA for 12 weeks with a 12-week wash-out period between... (More)
This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 20) and obese (BMI, 32.0 +/- 1.6 kg/m(2); n = 14) men participated in a double-blind placebo-controlled, randomized crossover study. Subjects received either 6 g/day control fat or 3 g/day CLA (50:50 cis-9, trans-11: trans-10, cis-12) and 3 g/day n-3 LC-PUFA for 12 weeks with a 12-week wash-out period between crossovers. Body composition was assessed by dual-energy X-ray absorptiometry. Fasting adiponectin, leptin, glucose, and insulin concentrations were measured and insulin resistance estimated by homeostasis model assessment for insulin resistance (HOMA-IR). In the younger obese subjects, CLA plus n-3 LC-PUFA supplementation compared with control fat did not result in increased abdominal fat and raised both fat-free mass (2.4%) and adiponectin levels (12%). CLA plus n-3 LC-PUFA showed no significant effects on HOMA-IR in any group but did increase fasting glucose in older obese subjects. In summary, supplementation with CLA plus n-3 LC-PUFA prevents increased abdominal fat mass and raises fat-free mass and adiponectin levels in younger obese individuals without deleteriously affecting insulin sensitivity, whereas these parameters in young and older lean and older obese individuals were unaffected, apart from increased fasting glucose in older obese men. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity
volume
16
issue
5
pages
1019 - 1024
publisher
Nature Publishing Group
external identifiers
  • wos:000255597600014
  • scopus:42949148605
ISSN
1930-739X
DOI
10.1038/oby.2008.41
language
English
LU publication?
yes
id
1d1d6b63-9b02-4e52-8d56-19941eeb8531 (old id 1204589)
date added to LUP
2016-04-01 11:41:32
date last changed
2024-10-08 06:14:09
@article{1d1d6b63-9b02-4e52-8d56-19941eeb8531,
  abstract     = {{This study aimed to determine the effect of supplementation with conjugated linoleic acids (CLAs) plus n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) on body composition, adiposity, and hormone levels in young and older, lean and obese men. Young (31.4 +/- 3.9 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 13) and obese (BMI, 32.4 +/- 1.9 kg/m(2); n = 12) and older (56.5 +/- 4.6 years) lean (BMI, 23.6 +/- 1.5 kg/m(2); n = 20) and obese (BMI, 32.0 +/- 1.6 kg/m(2); n = 14) men participated in a double-blind placebo-controlled, randomized crossover study. Subjects received either 6 g/day control fat or 3 g/day CLA (50:50 cis-9, trans-11: trans-10, cis-12) and 3 g/day n-3 LC-PUFA for 12 weeks with a 12-week wash-out period between crossovers. Body composition was assessed by dual-energy X-ray absorptiometry. Fasting adiponectin, leptin, glucose, and insulin concentrations were measured and insulin resistance estimated by homeostasis model assessment for insulin resistance (HOMA-IR). In the younger obese subjects, CLA plus n-3 LC-PUFA supplementation compared with control fat did not result in increased abdominal fat and raised both fat-free mass (2.4%) and adiponectin levels (12%). CLA plus n-3 LC-PUFA showed no significant effects on HOMA-IR in any group but did increase fasting glucose in older obese subjects. In summary, supplementation with CLA plus n-3 LC-PUFA prevents increased abdominal fat mass and raises fat-free mass and adiponectin levels in younger obese individuals without deleteriously affecting insulin sensitivity, whereas these parameters in young and older lean and older obese individuals were unaffected, apart from increased fasting glucose in older obese men.}},
  author       = {{Sneddon, Alan A and Tsofliou, Fotini and Fyfe, Claire L and Matheson, Ian and Jackson, Diane M and Horgan, Graham and Sörhede Winzell, Maria and Wahle, Klaus W J and Ahrén, Bo and Williams, Lynda M}},
  issn         = {{1930-739X}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1019--1024}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Obesity}},
  title        = {{Effect of a conjugated linoleic acid and omega-3 fatty acid mixture on body composition and adiponectin}},
  url          = {{http://dx.doi.org/10.1038/oby.2008.41}},
  doi          = {{10.1038/oby.2008.41}},
  volume       = {{16}},
  year         = {{2008}},
}