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No augmentation of morselized and impacted bone graft by OP-1 in a weight-bearing model.

Tägil, Magnus LU ; Jeppsson, Charlotte LU ; Wang, Jian-Sheng LU and Aspenberg, Per LU (2003) In Acta Orthopaedica Scandinavica 74(6). p.742-748
Abstract
Introduction: Impacted morselized bone allograft is thought to be remodeled to a great extent. We have previously shown that load-bearing increases the remodeling of impacted morselized bone allografts in a rabbit knee prosthesis model. Bone Morphogenic Proteins (BMPs) also stimulate bone formation and bone allograft remodeling. In this study, our aim was to determine whether it was possible to increase further the remodeling of impacted morselized bone allografts by combining load-bearing with a BMP. Experiment: A solution of Osteogenic Protein-1 (OP-1, also called BMP-7) was added to freeze-dried bone allograft chips before impaction grafting in our rabbit knee prosthesis model. 23 skeletally mature rabbits received an uncemented tibial... (More)
Introduction: Impacted morselized bone allograft is thought to be remodeled to a great extent. We have previously shown that load-bearing increases the remodeling of impacted morselized bone allografts in a rabbit knee prosthesis model. Bone Morphogenic Proteins (BMPs) also stimulate bone formation and bone allograft remodeling. In this study, our aim was to determine whether it was possible to increase further the remodeling of impacted morselized bone allografts by combining load-bearing with a BMP. Experiment: A solution of Osteogenic Protein-1 (OP-1, also called BMP-7) was added to freeze-dried bone allograft chips before impaction grafting in our rabbit knee prosthesis model. 23 skeletally mature rabbits received an uncemented tibial knee prosthetic component inserted into a bed of impacted morselized bone allograft. 12 rabbits were given OP-1-treated allograft (50 µg OP-1 per gram allograft), and 11 rabbits vehicle-treated allograft. Each rabbit received mean 0.53 g graft. The rabbits were killed after 3 or 6 weeks and the grafted region was examined by histomorphometric assessment of the volume fraction of newly formed bone and remaining graft. Results and interpretation: We found that OP-1 did not increase the bone density (graft plus new bone) to any substantial extent. However, we can not exclude that this might be due to a carrier problem, since the OP-1 was added as a solution directly to the dry graft. (Less)
Please use this url to cite or link to this publication:
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organization
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Contribution to journal
publication status
published
subject
keywords
Support, Animals, Bone Density: drug effects, Bone Morphogenetic Proteins: pharmacology, Rabbits, Animal, Bone Remodeling: drug effects, Knee Prosthesis, Models, Non-U.S. Gov't, Weight-Bearing
in
Acta Orthopaedica Scandinavica
volume
74
issue
6
pages
742 - 748
publisher
Taylor & Francis
external identifiers
  • wos:000187295200020
  • pmid:14763709
  • scopus:17944404659
ISSN
0001-6470
DOI
10.1080/00016470310018306
language
English
LU publication?
yes
id
4f66d7ee-f8bd-4eab-a84d-1effa78a8a1e (old id 120716)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=14763709&dopt=Abstract
date added to LUP
2007-07-04 10:31:22
date last changed
2018-05-29 12:24:58
@article{4f66d7ee-f8bd-4eab-a84d-1effa78a8a1e,
  abstract     = {Introduction: Impacted morselized bone allograft is thought to be remodeled to a great extent. We have previously shown that load-bearing increases the remodeling of impacted morselized bone allografts in a rabbit knee prosthesis model. Bone Morphogenic Proteins (BMPs) also stimulate bone formation and bone allograft remodeling. In this study, our aim was to determine whether it was possible to increase further the remodeling of impacted morselized bone allografts by combining load-bearing with a BMP. Experiment: A solution of Osteogenic Protein-1 (OP-1, also called BMP-7) was added to freeze-dried bone allograft chips before impaction grafting in our rabbit knee prosthesis model. 23 skeletally mature rabbits received an uncemented tibial knee prosthetic component inserted into a bed of impacted morselized bone allograft. 12 rabbits were given OP-1-treated allograft (50 µg OP-1 per gram allograft), and 11 rabbits vehicle-treated allograft. Each rabbit received mean 0.53 g graft. The rabbits were killed after 3 or 6 weeks and the grafted region was examined by histomorphometric assessment of the volume fraction of newly formed bone and remaining graft. Results and interpretation: We found that OP-1 did not increase the bone density (graft plus new bone) to any substantial extent. However, we can not exclude that this might be due to a carrier problem, since the OP-1 was added as a solution directly to the dry graft.},
  author       = {Tägil, Magnus and Jeppsson, Charlotte and Wang, Jian-Sheng and Aspenberg, Per},
  issn         = {0001-6470},
  keyword      = {Support,Animals,Bone Density: drug effects,Bone Morphogenetic Proteins: pharmacology,Rabbits,Animal,Bone Remodeling: drug effects,Knee Prosthesis,Models,Non-U.S. Gov't,Weight-Bearing},
  language     = {eng},
  number       = {6},
  pages        = {742--748},
  publisher    = {Taylor & Francis},
  series       = {Acta Orthopaedica Scandinavica},
  title        = {No augmentation of morselized and impacted bone graft by OP-1 in a weight-bearing model.},
  url          = {http://dx.doi.org/10.1080/00016470310018306},
  volume       = {74},
  year         = {2003},
}