Epidemiology, risk and prognostic factors in mesenteric venous thrombosis.
Acosta, Stefan LU
; Alhadad, Alaa
LU
; Svensson, Peter
LU
and Ekberg, Olle
LU
(2008)
In British Journal of Surgery
Aug 21.
p.1245-1251
- Abstract
- BACKGROUND:: Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis (MVT) are scarce. METHODS:: Patients with MVT were identified through the inpatient and autopsy registry between 2000 and 2006 at Malmö University Hospital. RESULTS:: Fifty-one patients had MVT, diagnosed at autopsy in six. The highest incidence (11.3 per 100 000 person-years) was in the age category 70-79 years. Activated protein C resistance was present in 13 of 29 patients tested. D-dimer at admission was raised in all five patients tested. Multidetector row computed tomography (CT) in the portal venous phase was diagnostic in all 20 patients investigated, of whom 19 were managed conservatively. The median length of resected... (More)
- BACKGROUND:: Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis (MVT) are scarce. METHODS:: Patients with MVT were identified through the inpatient and autopsy registry between 2000 and 2006 at Malmö University Hospital. RESULTS:: Fifty-one patients had MVT, diagnosed at autopsy in six. The highest incidence (11.3 per 100 000 person-years) was in the age category 70-79 years. Activated protein C resistance was present in 13 of 29 patients tested. D-dimer at admission was raised in all five patients tested. Multidetector row computed tomography (CT) in the portal venous phase was diagnostic in all 20 patients investigated, of whom 19 were managed conservatively. The median length of resected bowel in 12 patients who had surgery was 0.6 (range 0.1-2.2) m. The overall 30-day mortality rate was 20 per cent; intestinal infarction (P = 0.046), treatment on a non-surgical ward (P = 0.001) and CT not done (P = 0.022) were associated with increased mortality. Cancer was independently associated with long-term mortality: hazard ratio 4.03, 95 per cent confidence interval 1.03 to 15.85; P = 0.046. CONCLUSION:: Portal venous phase CT appeared sensitive in diagnosing MVT. As activated protein C resistance was a strong risk factor, lifelong anticoagulation should be considered. Copyright (c) 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1223003
- author
- Acosta, Stefan
LU
; Alhadad, Alaa
LU
; Svensson, Peter
LU
and Ekberg, Olle
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Surgery
- volume
- Aug 21
- pages
- 1245 - 1251
- publisher
- Oxford University Press
- external identifiers
-
- wos:000259713300007
- pmid:18720461
- scopus:52449091262
- ISSN
- 1365-2168
- DOI
- 10.1002/bjs.6319
- language
- English
- LU publication?
- yes
- id
- 6f0e0db4-e8f5-445f-ac15-d680a351f00b (old id 1223003)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18720461?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:30
- date last changed
- 2022-05-01 07:23:41
@article{6f0e0db4-e8f5-445f-ac15-d680a351f00b,
abstract = {{BACKGROUND:: Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis (MVT) are scarce. METHODS:: Patients with MVT were identified through the inpatient and autopsy registry between 2000 and 2006 at Malmö University Hospital. RESULTS:: Fifty-one patients had MVT, diagnosed at autopsy in six. The highest incidence (11.3 per 100 000 person-years) was in the age category 70-79 years. Activated protein C resistance was present in 13 of 29 patients tested. D-dimer at admission was raised in all five patients tested. Multidetector row computed tomography (CT) in the portal venous phase was diagnostic in all 20 patients investigated, of whom 19 were managed conservatively. The median length of resected bowel in 12 patients who had surgery was 0.6 (range 0.1-2.2) m. The overall 30-day mortality rate was 20 per cent; intestinal infarction (P = 0.046), treatment on a non-surgical ward (P = 0.001) and CT not done (P = 0.022) were associated with increased mortality. Cancer was independently associated with long-term mortality: hazard ratio 4.03, 95 per cent confidence interval 1.03 to 15.85; P = 0.046. CONCLUSION:: Portal venous phase CT appeared sensitive in diagnosing MVT. As activated protein C resistance was a strong risk factor, lifelong anticoagulation should be considered. Copyright (c) 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.}},
author = {{Acosta, Stefan and Alhadad, Alaa and Svensson, Peter and Ekberg, Olle}},
issn = {{1365-2168}},
language = {{eng}},
pages = {{1245--1251}},
publisher = {{Oxford University Press}},
series = {{British Journal of Surgery}},
title = {{Epidemiology, risk and prognostic factors in mesenteric venous thrombosis.}},
url = {{http://dx.doi.org/10.1002/bjs.6319}},
doi = {{10.1002/bjs.6319}},
volume = {{Aug 21}},
year = {{2008}},
}