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Deposition of biomass combustion aerosol particles in the human respiratory tract.

Löndahl, Jakob LU ; Pagels, Joakim; Boman, Christoffer; Swietlicki, Erik LU ; Massling, Andreas; Rissler, Jenny LU ; Blomberg, Anders; Bohgard, Mats LU and Sandström, Thomas (2008) In Inhalation Toxicology 20(10). p.923-933
Abstract
Smoke from biomass combustion has been identified as a major environmental risk factor associated with adverse health effects globally. Deposition of the smoke particles in the lungs is a crucial factor for toxicological effects, but has not previously been studied experimentally. We investigated the size-dependent respiratory-tract deposition of aerosol particles from wood combustion in humans. Two combustion conditions were studied in a wood pellet burner: efficient ("complete") combustion and low-temperature (incomplete) combustion simulating "wood smoke." The size-dependent deposition fraction of 15-to 680-nm particles was measured for 10 healthy subjects with a novel setup. Both aerosols were extensively characterized with regard to... (More)
Smoke from biomass combustion has been identified as a major environmental risk factor associated with adverse health effects globally. Deposition of the smoke particles in the lungs is a crucial factor for toxicological effects, but has not previously been studied experimentally. We investigated the size-dependent respiratory-tract deposition of aerosol particles from wood combustion in humans. Two combustion conditions were studied in a wood pellet burner: efficient ("complete") combustion and low-temperature (incomplete) combustion simulating "wood smoke." The size-dependent deposition fraction of 15-to 680-nm particles was measured for 10 healthy subjects with a novel setup. Both aerosols were extensively characterized with regard to chemical and physical particle properties. The deposition was additionally estimated with the ICRP model, modified for the determined aerosol properties, in order to validate the experiments and allow a generalization of the results. The measured total deposited fraction of particles from both efficient combustion and low-temperature combustion was 0.21-0.24 by number, surface, and mass. The deposition behavior can be explained by the size distributions of the particles and by their ability to grow by water uptake in the lungs, where the relative humidity is close to saturation. The experiments were in basic agreement with the model calculations. Our findings illustrate: (1) that particles from biomass combustion obtain a size in the respiratory tract at which the deposition probability is close to its minimum, (2) that particle water absorption has substantial impact on deposition, and (3) that deposition is markedly influenced by individual factors. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Inhalation Toxicology
volume
20
issue
10
pages
923 - 933
publisher
Taylor & Francis
external identifiers
  • wos:000258220000004
  • pmid:18668412
  • scopus:49249090575
ISSN
0895-8378
DOI
10.1080/08958370802087124
language
English
LU publication?
yes
id
3079ffbf-a773-4796-b54a-78c27b7e0bfb (old id 1223642)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18668412?dopt=Abstract
date added to LUP
2008-09-26 14:48:14
date last changed
2017-04-30 13:04:33
@article{3079ffbf-a773-4796-b54a-78c27b7e0bfb,
  abstract     = {Smoke from biomass combustion has been identified as a major environmental risk factor associated with adverse health effects globally. Deposition of the smoke particles in the lungs is a crucial factor for toxicological effects, but has not previously been studied experimentally. We investigated the size-dependent respiratory-tract deposition of aerosol particles from wood combustion in humans. Two combustion conditions were studied in a wood pellet burner: efficient ("complete") combustion and low-temperature (incomplete) combustion simulating "wood smoke." The size-dependent deposition fraction of 15-to 680-nm particles was measured for 10 healthy subjects with a novel setup. Both aerosols were extensively characterized with regard to chemical and physical particle properties. The deposition was additionally estimated with the ICRP model, modified for the determined aerosol properties, in order to validate the experiments and allow a generalization of the results. The measured total deposited fraction of particles from both efficient combustion and low-temperature combustion was 0.21-0.24 by number, surface, and mass. The deposition behavior can be explained by the size distributions of the particles and by their ability to grow by water uptake in the lungs, where the relative humidity is close to saturation. The experiments were in basic agreement with the model calculations. Our findings illustrate: (1) that particles from biomass combustion obtain a size in the respiratory tract at which the deposition probability is close to its minimum, (2) that particle water absorption has substantial impact on deposition, and (3) that deposition is markedly influenced by individual factors.},
  author       = {Löndahl, Jakob and Pagels, Joakim and Boman, Christoffer and Swietlicki, Erik and Massling, Andreas and Rissler, Jenny and Blomberg, Anders and Bohgard, Mats and Sandström, Thomas},
  issn         = {0895-8378},
  language     = {eng},
  number       = {10},
  pages        = {923--933},
  publisher    = {Taylor & Francis},
  series       = {Inhalation Toxicology},
  title        = {Deposition of biomass combustion aerosol particles in the human respiratory tract.},
  url          = {http://dx.doi.org/10.1080/08958370802087124},
  volume       = {20},
  year         = {2008},
}