Advanced

Soft tissue reactions evoked by implanted gallium phosphide.

Eriksson Linsmeier, Cecilia LU ; Wallman, Lars LU ; Faxius, Linda LU ; Schouenborg, Jens LU ; Bjursten, Lars Magnus LU and Danielsen, Nils LU (2008) In Biomaterials 29(35). p.4598-4604
Abstract
Neural devices may play an important role in the diagnosis and therapy of several clinical conditions, such as stroke, trauma or neurodegenerative disorders, by facilitating motor and pain control. Such interfaces, chronically implanted in the CNS, need to be biocompatible and have the ability to stimulate and record nerve signals. However, neural devices of today are not fully optimized. Nanostructured surfaces may improve electrical properties and lower evoked tissue responses. Vertical gallium phosphide (GaP) nanowires epitaxially grown from a GaP surface is one way of creating nanostructured electrodes. Thus, we chose to study the soft tissue reactions evoked by GaP surfaces. GaP and the control material titanium (Ti) were implanted in... (More)
Neural devices may play an important role in the diagnosis and therapy of several clinical conditions, such as stroke, trauma or neurodegenerative disorders, by facilitating motor and pain control. Such interfaces, chronically implanted in the CNS, need to be biocompatible and have the ability to stimulate and record nerve signals. However, neural devices of today are not fully optimized. Nanostructured surfaces may improve electrical properties and lower evoked tissue responses. Vertical gallium phosphide (GaP) nanowires epitaxially grown from a GaP surface is one way of creating nanostructured electrodes. Thus, we chose to study the soft tissue reactions evoked by GaP surfaces. GaP and the control material titanium (Ti) were implanted in the rat abdominal wall for evaluation of tissue reactions after 1, 6, or 12 weeks. The foreign-body response was evaluated by measuring the reactive capsule thickness and by quantification of ED1-positive macrophages and total cells in the capsule. Furthermore, the concentration of Ga was measured in blood, brain, liver and kidneys. Statistically significant differences were noticed between GaP and Ti at 12 weeks for total and ED1-positive cell densities in the capsule. The chemical analysis showed that the concentration of Ga in brain, liver and kidneys increased during 12 weeks of implantation, indicating loss of Ga from the implant. Taken together, our results show that the biocompatible properties of GaP are worse than those of the well-documented biomaterial Ti. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomaterials
volume
29
issue
35
pages
4598 - 4604
publisher
Elsevier
external identifiers
  • wos:000261864400004
  • pmid:18801568
  • scopus:53349164244
ISSN
1878-5905
DOI
10.1016/j.biomaterials.2008.08.028
language
English
LU publication?
yes
id
ff3a820d-0a61-443d-9b4b-37fe479cf24f (old id 1242887)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18801568?dopt=Abstract
date added to LUP
2008-10-07 14:37:21
date last changed
2017-05-21 04:33:27
@article{ff3a820d-0a61-443d-9b4b-37fe479cf24f,
  abstract     = {Neural devices may play an important role in the diagnosis and therapy of several clinical conditions, such as stroke, trauma or neurodegenerative disorders, by facilitating motor and pain control. Such interfaces, chronically implanted in the CNS, need to be biocompatible and have the ability to stimulate and record nerve signals. However, neural devices of today are not fully optimized. Nanostructured surfaces may improve electrical properties and lower evoked tissue responses. Vertical gallium phosphide (GaP) nanowires epitaxially grown from a GaP surface is one way of creating nanostructured electrodes. Thus, we chose to study the soft tissue reactions evoked by GaP surfaces. GaP and the control material titanium (Ti) were implanted in the rat abdominal wall for evaluation of tissue reactions after 1, 6, or 12 weeks. The foreign-body response was evaluated by measuring the reactive capsule thickness and by quantification of ED1-positive macrophages and total cells in the capsule. Furthermore, the concentration of Ga was measured in blood, brain, liver and kidneys. Statistically significant differences were noticed between GaP and Ti at 12 weeks for total and ED1-positive cell densities in the capsule. The chemical analysis showed that the concentration of Ga in brain, liver and kidneys increased during 12 weeks of implantation, indicating loss of Ga from the implant. Taken together, our results show that the biocompatible properties of GaP are worse than those of the well-documented biomaterial Ti.},
  author       = {Eriksson Linsmeier, Cecilia and Wallman, Lars and Faxius, Linda and Schouenborg, Jens and Bjursten, Lars Magnus and Danielsen, Nils},
  issn         = {1878-5905},
  language     = {eng},
  number       = {35},
  pages        = {4598--4604},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Soft tissue reactions evoked by implanted gallium phosphide.},
  url          = {http://dx.doi.org/10.1016/j.biomaterials.2008.08.028},
  volume       = {29},
  year         = {2008},
}