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Histopathological examinations of rat brains after long-term exposure to GSM-900 mobile phone radiation.

Grafström, Gustav LU ; Nittby, Henrietta LU ; Brun, Arne LU ; Malmgren, Lars LU ; Persson, Bertil R LU ; Salford, Leif LU and Eberhardt, Jacob LU (2008) In Brain Research Bulletin 77. p.257-263
Abstract
In order to mimic the real life situation, with often life-long exposure to the electromagnetic fields emitted by mobile phones, we have investigated in a rat model the effects of repeated exposures under a long period to Global System for Mobile Communication-900MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed once weekly in a 2-h period, for totally 55 weeks, at different average whole-body specific absorption rates (SAR) (of in average 0.6 and 60mW/kg at the initiation of the experimental period). The animals were exposed in a transverse electromagnetic transmission line chamber (TEM-cell) to radiation emitted by a GSM-900 test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never... (More)
In order to mimic the real life situation, with often life-long exposure to the electromagnetic fields emitted by mobile phones, we have investigated in a rat model the effects of repeated exposures under a long period to Global System for Mobile Communication-900MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed once weekly in a 2-h period, for totally 55 weeks, at different average whole-body specific absorption rates (SAR) (of in average 0.6 and 60mW/kg at the initiation of the experimental period). The animals were exposed in a transverse electromagnetic transmission line chamber (TEM-cell) to radiation emitted by a GSM-900 test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never left the animal house. After behavioural tests, 5-7 weeks after the last exposure, the brains were evaluated for histopathological alterations such as albumin extravasation, dark neurons, lipofuscin aggregation and signs of cytoskeletal and neuritic neuronal changes of the type seen in human ageing. In this study, no significant alteration of any these histopathological parameters was found, when comparing the GSM exposed animals to the sham exposed controls. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Brain Research Bulletin
volume
77
pages
257 - 263
publisher
Elsevier
external identifiers
  • wos:000261126400008
  • pmid:18782606
  • scopus:54549115167
ISSN
0361-9230
DOI
10.1016/j.brainresbull.2008.08.004
language
English
LU publication?
yes
id
ffc79cb6-d31e-494a-bc36-8a9592cb5afa (old id 1243196)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18782606?dopt=Abstract
date added to LUP
2008-10-07 13:31:06
date last changed
2017-08-27 05:46:53
@article{ffc79cb6-d31e-494a-bc36-8a9592cb5afa,
  abstract     = {In order to mimic the real life situation, with often life-long exposure to the electromagnetic fields emitted by mobile phones, we have investigated in a rat model the effects of repeated exposures under a long period to Global System for Mobile Communication-900MHz (GSM-900) radiation. Out of a total of 56 rats, 32 were exposed once weekly in a 2-h period, for totally 55 weeks, at different average whole-body specific absorption rates (SAR) (of in average 0.6 and 60mW/kg at the initiation of the experimental period). The animals were exposed in a transverse electromagnetic transmission line chamber (TEM-cell) to radiation emitted by a GSM-900 test phone. Sixteen animals were sham exposed and eight animals were cage controls, which never left the animal house. After behavioural tests, 5-7 weeks after the last exposure, the brains were evaluated for histopathological alterations such as albumin extravasation, dark neurons, lipofuscin aggregation and signs of cytoskeletal and neuritic neuronal changes of the type seen in human ageing. In this study, no significant alteration of any these histopathological parameters was found, when comparing the GSM exposed animals to the sham exposed controls.},
  author       = {Grafström, Gustav and Nittby, Henrietta and Brun, Arne and Malmgren, Lars and Persson, Bertil R and Salford, Leif and Eberhardt, Jacob},
  issn         = {0361-9230},
  language     = {eng},
  pages        = {257--263},
  publisher    = {Elsevier},
  series       = {Brain Research Bulletin},
  title        = {Histopathological examinations of rat brains after long-term exposure to GSM-900 mobile phone radiation.},
  url          = {http://dx.doi.org/10.1016/j.brainresbull.2008.08.004},
  volume       = {77},
  year         = {2008},
}