Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.
(2008) In Acta Diabetologica Sep 4. p.231-235- Abstract
- The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in... (More)
- The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1243373
- author
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Diabetologica
- volume
- Sep 4
- pages
- 231 - 235
- publisher
- Springer
- external identifiers
-
- wos:000260538200006
- pmid:18769865
- scopus:55949118394
- pmid:18769865
- ISSN
- 1432-5233
- DOI
- 10.1007/s00592-008-0048-5
- language
- English
- LU publication?
- yes
- id
- 446a7cab-da22-47d7-8a99-cb71dcbeb315 (old id 1243373)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18769865?dopt=Abstract
- date added to LUP
- 2016-04-04 09:33:57
- date last changed
- 2024-10-13 03:20:12
@article{446a7cab-da22-47d7-8a99-cb71dcbeb315, abstract = {{The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.}}, author = {{Lindehammer, Sabina and Larsson, Karin and Örtqvist, Eva and Carlsson, Annelie and Cederwall, E and Cilio, Corrado and Ivarsson, S-A and Jönsson, B. and Larsson, Helena and Lynch, Kristian and Neiderud, Jan and Nilsson, Anna and Sjöblad, Sture and Lernmark, Åke}}, issn = {{1432-5233}}, language = {{eng}}, pages = {{231--235}}, publisher = {{Springer}}, series = {{Acta Diabetologica}}, title = {{Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.}}, url = {{http://dx.doi.org/10.1007/s00592-008-0048-5}}, doi = {{10.1007/s00592-008-0048-5}}, volume = {{Sep 4}}, year = {{2008}}, }