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Research in motion: the enigma of Parkinson's disease pathology spread.

Brundin, Patrik LU ; Li, Jia-Yi LU ; Holton, Janice L ; Lindvall, Olle LU and Revesz, Tamas (2008) In Nature Reviews Neuroscience 9(10). p.741-745
Abstract
Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neuroscience
volume
9
issue
10
pages
741 - 745
publisher
Nature Publishing Group
external identifiers
  • wos:000259323200011
  • pmid:18769444
  • scopus:52449117926
  • pmid:18769444
ISSN
1471-003X
DOI
10.1038/nrn2477
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neural Plasticity and Repair (013210080), Neurogenesis and cell therapy (013027500)
id
6c3c5a98-2b77-47d9-abae-088eec0ebc59 (old id 1243401)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18769444?dopt=Abstract
date added to LUP
2016-04-04 09:04:46
date last changed
2022-04-23 18:52:58
@article{6c3c5a98-2b77-47d9-abae-088eec0ebc59,
  abstract     = {{Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the diseased brains. According to these studies, implanted neurons developed alpha-synuclein- and ubiquitin-positive Lewy bodies more than a decade after transplantation. We discuss the possible underlying mechanisms and their implications for how pathology spreads in Parkinson's disease.}},
  author       = {{Brundin, Patrik and Li, Jia-Yi and Holton, Janice L and Lindvall, Olle and Revesz, Tamas}},
  issn         = {{1471-003X}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{741--745}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Neuroscience}},
  title        = {{Research in motion: the enigma of Parkinson's disease pathology spread.}},
  url          = {{http://dx.doi.org/10.1038/nrn2477}},
  doi          = {{10.1038/nrn2477}},
  volume       = {{9}},
  year         = {{2008}},
}