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High maternal body mass index increases the risk of neonatal early onset group B streptococcal disease

Hakansson, Stellan and Källén, Karin LU (2008) In Acta Pædiatrica 97(10). p.1386-1389
Abstract
Objective: The aim of this study was to analyse the occurrence of neonatal early onset group B streptococcal (EOGBS) disease relative to maternal body mass index (BMI). Method: A cohort of Swedish parturients with an early pregnancy BMI registered was investigated. Data were retrieved from population-based registers during 1997-2001, (n = 344 127, elective caesarean section excluded). Medical records of all infants with a diagnosis of EOGBS septicaemia (P36.0) were scrutinized for verification of the diagnosis. There were 136 cases with blood culture-positive septicaemia and 112 cases with clinical infection. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multiple logistic regression. Results: In obese parturients... (More)
Objective: The aim of this study was to analyse the occurrence of neonatal early onset group B streptococcal (EOGBS) disease relative to maternal body mass index (BMI). Method: A cohort of Swedish parturients with an early pregnancy BMI registered was investigated. Data were retrieved from population-based registers during 1997-2001, (n = 344 127, elective caesarean section excluded). Medical records of all infants with a diagnosis of EOGBS septicaemia (P36.0) were scrutinized for verification of the diagnosis. There were 136 cases with blood culture-positive septicaemia and 112 cases with clinical infection. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multiple logistic regression. Results: In obese parturients with BMI > 30, there was an 80% increased risk for verified neonatal EOGBS disease (OR 1.8, 95% CI 1.1-3.0). When cases with clinical sepsis were included a significant risk increment was also found in overweight women with BMI 25.0-29.9 (OR 1.5, 95% CI 1.1-2.0). Conclusion: Maternal obesity and overweight are risk factors associated with increased risk of neonatal EOGBS disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
obesity, newborn, group B streptococcus, body mass index, septicaemia, early onset
in
Acta Pædiatrica
volume
97
issue
10
pages
1386 - 1389
publisher
Taylor & Francis
external identifiers
  • wos:000259146200017
  • scopus:51349163603
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2008.00940.x
language
English
LU publication?
yes
id
a636500a-9712-4f47-ba04-d83ee8df4d0d (old id 1247139)
date added to LUP
2008-11-12 11:45:36
date last changed
2017-03-19 03:49:47
@article{a636500a-9712-4f47-ba04-d83ee8df4d0d,
  abstract     = {Objective: The aim of this study was to analyse the occurrence of neonatal early onset group B streptococcal (EOGBS) disease relative to maternal body mass index (BMI). Method: A cohort of Swedish parturients with an early pregnancy BMI registered was investigated. Data were retrieved from population-based registers during 1997-2001, (n = 344 127, elective caesarean section excluded). Medical records of all infants with a diagnosis of EOGBS septicaemia (P36.0) were scrutinized for verification of the diagnosis. There were 136 cases with blood culture-positive septicaemia and 112 cases with clinical infection. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multiple logistic regression. Results: In obese parturients with BMI > 30, there was an 80% increased risk for verified neonatal EOGBS disease (OR 1.8, 95% CI 1.1-3.0). When cases with clinical sepsis were included a significant risk increment was also found in overweight women with BMI 25.0-29.9 (OR 1.5, 95% CI 1.1-2.0). Conclusion: Maternal obesity and overweight are risk factors associated with increased risk of neonatal EOGBS disease.},
  author       = {Hakansson, Stellan and Källén, Karin},
  issn         = {1651-2227},
  keyword      = {obesity,newborn,group B streptococcus,body mass index,septicaemia,early onset},
  language     = {eng},
  number       = {10},
  pages        = {1386--1389},
  publisher    = {Taylor & Francis},
  series       = {Acta Pædiatrica},
  title        = {High maternal body mass index increases the risk of neonatal early onset group B streptococcal disease},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2008.00940.x},
  volume       = {97},
  year         = {2008},
}