Annual screening detects celiac disease in children with type 1 diabetes
Larsson, Karin ; Carlsson, Annelie LU
; Cederwall, Elisabeth
; Jonsson, Bjorn
; Neiderud, Jan
; Jonsson, Bjorn
; Lernmark, Åke
LU
and Ivarsson, Sten
LU
(2008)
In Pediatric Diabetes
9(4).
p.354-359
- Abstract
- Objective: To investigate the prevalence of celiac disease (CD) in a cohort of type 1 diabetes mellitus (T1DM) children and adolescents at the time of clinical diagnosis and to evaluate the screening procedure and possible role of human leukocyte antigen (HLA)-DQ during a 5-yr follow-up. Research design and methods: The study group was a cohort of 300 newly diagnosed T1DM children and youths younger than 20 yr followed for 5 yr at six clinical centers for pediatric diabetes in the region Skane in Sweden. Immunoglobulin A endomysium antibodies were used to screen the patients annually to be considered for an intestinal biopsy. All patients were analyzed for HLA-DQA1-B1 genotypes. Results: While 0.7% (2/300) already had a diagnosed... (More)
- Objective: To investigate the prevalence of celiac disease (CD) in a cohort of type 1 diabetes mellitus (T1DM) children and adolescents at the time of clinical diagnosis and to evaluate the screening procedure and possible role of human leukocyte antigen (HLA)-DQ during a 5-yr follow-up. Research design and methods: The study group was a cohort of 300 newly diagnosed T1DM children and youths younger than 20 yr followed for 5 yr at six clinical centers for pediatric diabetes in the region Skane in Sweden. Immunoglobulin A endomysium antibodies were used to screen the patients annually to be considered for an intestinal biopsy. All patients were analyzed for HLA-DQA1-B1 genotypes. Results: While 0.7% (2/300) already had a diagnosed symptomatic CD, an additional 3% (10/300) had silent CD at the diagnosis of T1DM. During follow-up, another 6% (17/300) developed CD as follows: 10 after 1 yr, 5 after 2 yr, 1 after 3 yr, and 1 after 5 yr. Therefore, the cumulative frequency of CD confirmed by intestinal biopsies was 10% (29/300). HLA genotypes among T1DM patients developing CD were not different from those among patients with T1DM alone. Conclusions: Our study confirmed the low prevalence (0.7%) of diagnosed symptomatic CD at the time of clinical diagnosis but document by screening an increasing prevalence of silent CD during a 5-yr follow-up to reach an overall prevalence of 10%. We suggest that children with T1DM should be screened for CD at the onset of T1DM and annually for a minimum of at least 2 yr. HLA genotypes among T1DM patients developing CD were not different from those among patients with T1DM alone. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1253614
- author
- Larsson, Karin
; Carlsson, Annelie
LU
; Cederwall, Elisabeth
; Jonsson, Bjorn
; Neiderud, Jan
; Jonsson, Bjorn
; Lernmark, Åke
LU
and Ivarsson, Sten
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- HLA-DQ, children, T1DM, annual screening, CD
- in
- Pediatric Diabetes
- volume
- 9
- issue
- 4
- pages
- 354 - 359
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000258078500003
- scopus:48649090823
- pmid:18774995
- ISSN
- 1399-543X
- DOI
- 10.1111/j.1399-5448.2008.00367.x
- language
- English
- LU publication?
- yes
- id
- 5d81077a-5e36-48a0-8f1e-226ed4fc0cfb (old id 1253614)
- date added to LUP
- 2016-04-01 12:15:37
- date last changed
- 2022-03-13 07:28:48
@article{5d81077a-5e36-48a0-8f1e-226ed4fc0cfb,
abstract = {{Objective: To investigate the prevalence of celiac disease (CD) in a cohort of type 1 diabetes mellitus (T1DM) children and adolescents at the time of clinical diagnosis and to evaluate the screening procedure and possible role of human leukocyte antigen (HLA)-DQ during a 5-yr follow-up. Research design and methods: The study group was a cohort of 300 newly diagnosed T1DM children and youths younger than 20 yr followed for 5 yr at six clinical centers for pediatric diabetes in the region Skane in Sweden. Immunoglobulin A endomysium antibodies were used to screen the patients annually to be considered for an intestinal biopsy. All patients were analyzed for HLA-DQA1-B1 genotypes. Results: While 0.7% (2/300) already had a diagnosed symptomatic CD, an additional 3% (10/300) had silent CD at the diagnosis of T1DM. During follow-up, another 6% (17/300) developed CD as follows: 10 after 1 yr, 5 after 2 yr, 1 after 3 yr, and 1 after 5 yr. Therefore, the cumulative frequency of CD confirmed by intestinal biopsies was 10% (29/300). HLA genotypes among T1DM patients developing CD were not different from those among patients with T1DM alone. Conclusions: Our study confirmed the low prevalence (0.7%) of diagnosed symptomatic CD at the time of clinical diagnosis but document by screening an increasing prevalence of silent CD during a 5-yr follow-up to reach an overall prevalence of 10%. We suggest that children with T1DM should be screened for CD at the onset of T1DM and annually for a minimum of at least 2 yr. HLA genotypes among T1DM patients developing CD were not different from those among patients with T1DM alone.}},
author = {{Larsson, Karin and Carlsson, Annelie and Cederwall, Elisabeth and Jonsson, Bjorn and Neiderud, Jan and Jonsson, Bjorn and Lernmark, Åke and Ivarsson, Sten}},
issn = {{1399-543X}},
keywords = {{HLA-DQ; children; T1DM; annual screening; CD}},
language = {{eng}},
number = {{4}},
pages = {{354--359}},
publisher = {{Wiley-Blackwell}},
series = {{Pediatric Diabetes}},
title = {{Annual screening detects celiac disease in children with type 1 diabetes}},
url = {{http://dx.doi.org/10.1111/j.1399-5448.2008.00367.x}},
doi = {{10.1111/j.1399-5448.2008.00367.x}},
volume = {{9}},
year = {{2008}},
}