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Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease

Gerhardsson, Lars; Lundh, Thomas LU ; Minthon, Lennart LU and Londos, Elisabet LU (2008) In Dementia and Geriatric Cognitive Disorders 25(6). p.508-515
Abstract
Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer's disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p... (More)
Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer's disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p < 0.001) and AD + vasc (p <= 0.013) than in controls. In CSF, however, the concentrations of vanadium, manganese, rubidium, antimony, cesium and lead were significantly lower among subjects with AD (p <= 0.010) and AD + vasc (p <= 0.047) than in controls. Strong positive correlations were noted between plasma Cs versus CSF Cs in subjects with AD (r(s) = 0.50; p < 0.001), and AD + vasc (r(s) = 0.68; p < 0.001). Conclusion: Besides the raised plasma mercury concentrations, no consistent metal pattern in plasma or CSF was observed in patients with AD. Copyright (c) 2008 S. Karger AG, Basel. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cerebrospinal fluid, plasma, Alzheimer's disease, metals
in
Dementia and Geriatric Cognitive Disorders
volume
25
issue
6
pages
508 - 515
publisher
Karger
external identifiers
  • wos:000257515500004
  • scopus:46849101764
ISSN
1420-8008
DOI
10.1159/000129365
language
English
LU publication?
yes
id
2551ae85-affc-4870-916e-c186b1908dce (old id 1255027)
date added to LUP
2008-10-17 14:02:24
date last changed
2017-11-19 03:29:45
@article{2551ae85-affc-4870-916e-c186b1908dce,
  abstract     = {Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer's disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p &lt; 0.001) and AD + vasc (p &lt;= 0.013) than in controls. In CSF, however, the concentrations of vanadium, manganese, rubidium, antimony, cesium and lead were significantly lower among subjects with AD (p &lt;= 0.010) and AD + vasc (p &lt;= 0.047) than in controls. Strong positive correlations were noted between plasma Cs versus CSF Cs in subjects with AD (r(s) = 0.50; p &lt; 0.001), and AD + vasc (r(s) = 0.68; p &lt; 0.001). Conclusion: Besides the raised plasma mercury concentrations, no consistent metal pattern in plasma or CSF was observed in patients with AD. Copyright (c) 2008 S. Karger AG, Basel.},
  author       = {Gerhardsson, Lars and Lundh, Thomas and Minthon, Lennart and Londos, Elisabet},
  issn         = {1420-8008},
  keyword      = {cerebrospinal fluid,plasma,Alzheimer's disease,metals},
  language     = {eng},
  number       = {6},
  pages        = {508--515},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease},
  url          = {http://dx.doi.org/10.1159/000129365},
  volume       = {25},
  year         = {2008},
}