Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease
(2008) In Dementia and Geriatric Cognitive Disorders 25(6). p.508-515- Abstract
- Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer's disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p... (More)
- Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer's disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p < 0.001) and AD + vasc (p <= 0.013) than in controls. In CSF, however, the concentrations of vanadium, manganese, rubidium, antimony, cesium and lead were significantly lower among subjects with AD (p <= 0.010) and AD + vasc (p <= 0.047) than in controls. Strong positive correlations were noted between plasma Cs versus CSF Cs in subjects with AD (r(s) = 0.50; p < 0.001), and AD + vasc (r(s) = 0.68; p < 0.001). Conclusion: Besides the raised plasma mercury concentrations, no consistent metal pattern in plasma or CSF was observed in patients with AD. Copyright (c) 2008 S. Karger AG, Basel. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1255027
- author
- Gerhardsson, Lars ; Lundh, Thomas LU ; Minthon, Lennart LU and Londos, Elisabet LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerebrospinal fluid, plasma, Alzheimer's disease, metals
- in
- Dementia and Geriatric Cognitive Disorders
- volume
- 25
- issue
- 6
- pages
- 508 - 515
- publisher
- Karger
- external identifiers
-
- wos:000257515500004
- scopus:46849101764
- ISSN
- 1420-8008
- DOI
- 10.1159/000129365
- language
- English
- LU publication?
- yes
- id
- 2551ae85-affc-4870-916e-c186b1908dce (old id 1255027)
- date added to LUP
- 2016-04-01 11:53:30
- date last changed
- 2022-04-20 23:19:55
@article{2551ae85-affc-4870-916e-c186b1908dce, abstract = {{Background/Aims: The homeostasis of essential metals such as copper, iron, selenium and zinc may be altered in the brain of subjects with Alzheimer's disease (AD). Methods: Concentrations of metals (magnesium, calcium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, tin, antimony, cesium, mercury and lead) were determined in plasma and cerebrospinal fluid (CSF) by inductively coupled plasma mass spectrometry in 173 patients with AD and in 87 patients with the combination of AD and minor vascular components (AD + vasc). Comparison was made with 54 healthy controls. Results: The plasma concentrations of manganese and total mercury were significantly higher in subjects with AD (p < 0.001) and AD + vasc (p <= 0.013) than in controls. In CSF, however, the concentrations of vanadium, manganese, rubidium, antimony, cesium and lead were significantly lower among subjects with AD (p <= 0.010) and AD + vasc (p <= 0.047) than in controls. Strong positive correlations were noted between plasma Cs versus CSF Cs in subjects with AD (r(s) = 0.50; p < 0.001), and AD + vasc (r(s) = 0.68; p < 0.001). Conclusion: Besides the raised plasma mercury concentrations, no consistent metal pattern in plasma or CSF was observed in patients with AD. Copyright (c) 2008 S. Karger AG, Basel.}}, author = {{Gerhardsson, Lars and Lundh, Thomas and Minthon, Lennart and Londos, Elisabet}}, issn = {{1420-8008}}, keywords = {{cerebrospinal fluid; plasma; Alzheimer's disease; metals}}, language = {{eng}}, number = {{6}}, pages = {{508--515}}, publisher = {{Karger}}, series = {{Dementia and Geriatric Cognitive Disorders}}, title = {{Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease}}, url = {{http://dx.doi.org/10.1159/000129365}}, doi = {{10.1159/000129365}}, volume = {{25}}, year = {{2008}}, }