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The usefulness of cube copying for evaluating treatment of Alzheimer's disease.

Palmqvist, Sebastian LU ; Hansson, Oskar LU ; Minthon, Lennart LU and Londos, Elisabet LU (2008) In American Journal of Alzheimers Disease & other Dementias 23(5). p.439-446
Abstract
Aims: Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD. Methods: Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined. Results: The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was... (More)
Aims: Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD. Methods: Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined. Results: The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was unchanged.Conclusions: The results indicate that cube copying can be used to evaluate ChEI treatment. It might also show a more long-lasting response to treatment than MMSE. Cube copying only measures a narrow cognitive function and can preferably be used with MMSE, which evaluates visuospatial ability poorly. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
American Journal of Alzheimers Disease & other Dementias
volume
23
issue
5
pages
439 - 446
publisher
SAGE Publications Inc.
external identifiers
  • wos:000260312400005
  • pmid:18955723
  • scopus:54049121404
ISSN
1938-2731
DOI
10.1177/1533317508320084
language
English
LU publication?
yes
id
f76a0a19-11b9-409c-8b7e-b2845ea1fe3f (old id 1261884)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18955723?dopt=Abstract
date added to LUP
2008-11-04 11:39:20
date last changed
2017-05-21 04:30:44
@article{f76a0a19-11b9-409c-8b7e-b2845ea1fe3f,
  abstract     = {Aims: Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD. Methods: Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined. Results: The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was unchanged.Conclusions: The results indicate that cube copying can be used to evaluate ChEI treatment. It might also show a more long-lasting response to treatment than MMSE. Cube copying only measures a narrow cognitive function and can preferably be used with MMSE, which evaluates visuospatial ability poorly.},
  author       = {Palmqvist, Sebastian and Hansson, Oskar and Minthon, Lennart and Londos, Elisabet},
  issn         = {1938-2731},
  language     = {eng},
  number       = {5},
  pages        = {439--446},
  publisher    = {SAGE Publications Inc.},
  series       = {American Journal of Alzheimers Disease & other Dementias},
  title        = {The usefulness of cube copying for evaluating treatment of Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1177/1533317508320084},
  volume       = {23},
  year         = {2008},
}