The usefulness of cube copying for evaluating treatment of Alzheimer's disease.
(2008) In American Journal of Alzheimers Disease & other Dementias 23(5). p.439-446- Abstract
- Aims: Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD. Methods: Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined. Results: The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was... (More)
- Aims: Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD. Methods: Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined. Results: The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was unchanged.Conclusions: The results indicate that cube copying can be used to evaluate ChEI treatment. It might also show a more long-lasting response to treatment than MMSE. Cube copying only measures a narrow cognitive function and can preferably be used with MMSE, which evaluates visuospatial ability poorly. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1261884
- author
- Palmqvist, Sebastian
LU
; Hansson, Oskar LU
; Minthon, Lennart LU and Londos, Elisabet LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Alzheimers Disease & other Dementias
- volume
- 23
- issue
- 5
- pages
- 439 - 446
- publisher
- SAGE Publications
- external identifiers
-
- wos:000260312400005
- pmid:18955723
- scopus:54049121404
- pmid:18955723
- ISSN
- 1938-2731
- DOI
- 10.1177/1533317508320084
- language
- English
- LU publication?
- yes
- id
- f76a0a19-11b9-409c-8b7e-b2845ea1fe3f (old id 1261884)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18955723?dopt=Abstract
- date added to LUP
- 2016-04-04 06:58:29
- date last changed
- 2022-04-15 18:26:29
@article{f76a0a19-11b9-409c-8b7e-b2845ea1fe3f, abstract = {{Aims: Cube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD. Methods: Eighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined. Results: The healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was unchanged.Conclusions: The results indicate that cube copying can be used to evaluate ChEI treatment. It might also show a more long-lasting response to treatment than MMSE. Cube copying only measures a narrow cognitive function and can preferably be used with MMSE, which evaluates visuospatial ability poorly.}}, author = {{Palmqvist, Sebastian and Hansson, Oskar and Minthon, Lennart and Londos, Elisabet}}, issn = {{1938-2731}}, language = {{eng}}, number = {{5}}, pages = {{439--446}}, publisher = {{SAGE Publications}}, series = {{American Journal of Alzheimers Disease & other Dementias}}, title = {{The usefulness of cube copying for evaluating treatment of Alzheimer's disease.}}, url = {{http://dx.doi.org/10.1177/1533317508320084}}, doi = {{10.1177/1533317508320084}}, volume = {{23}}, year = {{2008}}, }