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Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data.

Robolge, Lenora LU ; Gerdhem, Paul LU ; Obrant, Karl LU and Ivaska, Kaisa LU (2009) In Osteoporosis International 20(7). p.1225-1232
Abstract
Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited. METHODS: Eight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up. RESULTS: All bone... (More)
Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited. METHODS: Eight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up. RESULTS: All bone turnover markers were correlated with baseline QUS [standardized regression (Beta(std)) values from -0.07, p < 0.05 to -0.23, p < 0.001], with the exception of bone-specific alkaline phosphatase (S-Bone ALP) which was not correlated with BUA and stiffness index. When the correlations between baseline bone turnover markers and 5-year changes in QUS were analyzed, three serum osteocalcins were correlated with changes of SoS and stiffness index (Beta(std) = -0.11, p < 0.05 to -0.17, p < 0.001). Also S-CTX-I correlated with changes of SoS and stiffness index (Beta(std) = -0.10 and -0.09, respectively, p < 0.05). S-TRACP5b, urinary deoxypyridinoline/crea, and U-MidOC/crea correlated with changes of SoS (Beta(std) = -0.10 and p < 0.05 for all). S-Bone ALP did not correlate with change of QUS. None of the bone turnover markers correlated with changes of BUA. CONCLUSIONS: Bone turnover markers correlate with concomitantly assessed QUS as well as with longitudinal change in QUS. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Osteoporosis International
volume
20
issue
7
pages
1225 - 1232
publisher
Springer
external identifiers
  • wos:000266665800015
  • pmid:18949532
  • scopus:67349239700
ISSN
1433-2965
DOI
10.1007/s00198-008-0769-x
language
English
LU publication?
yes
id
f13f6bc5-e410-4ba8-a3c6-dc7ef83c5f31 (old id 1261998)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18949532?dopt=Abstract
date added to LUP
2008-11-04 10:34:25
date last changed
2017-08-20 03:53:16
@article{f13f6bc5-e410-4ba8-a3c6-dc7ef83c5f31,
  abstract     = {Associations between bone turnover markers and calcaneal ultrasound (quantitative ultrasound, QUS) were studied in a population-based sample of 810 elderly women. Baseline bone turnover markers correlated with baseline QUS as well as with 5-year prospective changes in QUS. INTRODUCTION: Bone turnover markers are associated with areal bone mineral density, but the knowledge on the association with QUS is limited. METHODS: Eight hundred ten women, all 75 years old, were investigated at baseline. Five hundred six completed a 5-year follow-up. Bone turnover markers and calcaneal QUS [speed of sound (SoS), broadband ultrasound attenuation (BUA), stiffness] were investigated at baseline. QUS was investigated at follow-up. RESULTS: All bone turnover markers were correlated with baseline QUS [standardized regression (Beta(std)) values from -0.07, p &lt; 0.05 to -0.23, p &lt; 0.001], with the exception of bone-specific alkaline phosphatase (S-Bone ALP) which was not correlated with BUA and stiffness index. When the correlations between baseline bone turnover markers and 5-year changes in QUS were analyzed, three serum osteocalcins were correlated with changes of SoS and stiffness index (Beta(std) = -0.11, p &lt; 0.05 to -0.17, p &lt; 0.001). Also S-CTX-I correlated with changes of SoS and stiffness index (Beta(std) = -0.10 and -0.09, respectively, p &lt; 0.05). S-TRACP5b, urinary deoxypyridinoline/crea, and U-MidOC/crea correlated with changes of SoS (Beta(std) = -0.10 and p &lt; 0.05 for all). S-Bone ALP did not correlate with change of QUS. None of the bone turnover markers correlated with changes of BUA. CONCLUSIONS: Bone turnover markers correlate with concomitantly assessed QUS as well as with longitudinal change in QUS.},
  author       = {Robolge, Lenora and Gerdhem, Paul and Obrant, Karl and Ivaska, Kaisa},
  issn         = {1433-2965},
  language     = {eng},
  number       = {7},
  pages        = {1225--1232},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data.},
  url          = {http://dx.doi.org/10.1007/s00198-008-0769-x},
  volume       = {20},
  year         = {2009},
}