Arterial Gastroduodenal Infusion of Cholecystokinin-33 Stimulates the Exocrine Pancreatic Enzyme Release Via an Enteropancreatic Reflex, Without Affecting the Endocrine Insulin Secretion in Pigs.
(2009) In Pancreas 38. p.213-218- Abstract
- OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs... (More)
- OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs after local infusion to the antral-duodenal area, whereas it had no effect after systemic infusion. Cholecystokinin-33 in the pharmacological dose range 64 to 130 pmol kg 10 min further increased the secretion after both local and systemic infusions. Only CCK-33 infusions in the pharmacological dose range were able to elevate the plasma insulin levels. Vagotomy had no effect on CCK-33-mediated stimulation of the enzyme release, whereas it had a significant effect on the plasma insulin level. CONCLUSIONS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min stimulates the enzyme secretion but had no effect on the insulin release via a short enteropancreatic pathway in pigs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1262248
- author
- Rengman, Sofia LU ; Weström, Björn LU ; Ahrén, Bo LU and Pierzynowski, Stefan LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pancreas
- volume
- 38
- pages
- 213 - 218
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000263905700018
- scopus:65349184484
- pmid:18852685
- ISSN
- 0885-3177
- DOI
- 10.1097/MPA.0b013e31818adf32
- language
- English
- LU publication?
- yes
- id
- 4f91f1ac-83a8-480b-9e9a-b594871af6ab (old id 1262248)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18852685?dopt=Abstract
- date added to LUP
- 2016-04-01 11:45:57
- date last changed
- 2024-01-07 19:40:02
@article{4f91f1ac-83a8-480b-9e9a-b594871af6ab,
abstract = {{OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs after local infusion to the antral-duodenal area, whereas it had no effect after systemic infusion. Cholecystokinin-33 in the pharmacological dose range 64 to 130 pmol kg 10 min further increased the secretion after both local and systemic infusions. Only CCK-33 infusions in the pharmacological dose range were able to elevate the plasma insulin levels. Vagotomy had no effect on CCK-33-mediated stimulation of the enzyme release, whereas it had a significant effect on the plasma insulin level. CONCLUSIONS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min stimulates the enzyme secretion but had no effect on the insulin release via a short enteropancreatic pathway in pigs.}},
author = {{Rengman, Sofia and Weström, Björn and Ahrén, Bo and Pierzynowski, Stefan}},
issn = {{0885-3177}},
language = {{eng}},
pages = {{213--218}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Pancreas}},
title = {{Arterial Gastroduodenal Infusion of Cholecystokinin-33 Stimulates the Exocrine Pancreatic Enzyme Release Via an Enteropancreatic Reflex, Without Affecting the Endocrine Insulin Secretion in Pigs.}},
url = {{http://dx.doi.org/10.1097/MPA.0b013e31818adf32}},
doi = {{10.1097/MPA.0b013e31818adf32}},
volume = {{38}},
year = {{2009}},
}