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Arterial Gastroduodenal Infusion of Cholecystokinin-33 Stimulates the Exocrine Pancreatic Enzyme Release Via an Enteropancreatic Reflex, Without Affecting the Endocrine Insulin Secretion in Pigs.

Rengman, Sofia LU ; Weström, Björn LU ; Ahrén, Bo LU and Pierzynowski, Stefan LU (2009) In Pancreas 38. p.213-218
Abstract
OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs... (More)
OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs after local infusion to the antral-duodenal area, whereas it had no effect after systemic infusion. Cholecystokinin-33 in the pharmacological dose range 64 to 130 pmol kg 10 min further increased the secretion after both local and systemic infusions. Only CCK-33 infusions in the pharmacological dose range were able to elevate the plasma insulin levels. Vagotomy had no effect on CCK-33-mediated stimulation of the enzyme release, whereas it had a significant effect on the plasma insulin level. CONCLUSIONS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min stimulates the enzyme secretion but had no effect on the insulin release via a short enteropancreatic pathway in pigs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pancreas
volume
38
pages
213 - 218
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000263905700018
  • scopus:65349184484
ISSN
0885-3177
DOI
10.1097/MPA.0b013e31818adf32
language
English
LU publication?
yes
id
4f91f1ac-83a8-480b-9e9a-b594871af6ab (old id 1262248)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18852685?dopt=Abstract
date added to LUP
2009-02-11 12:56:19
date last changed
2017-01-01 04:31:16
@article{4f91f1ac-83a8-480b-9e9a-b594871af6ab,
  abstract     = {OBJECTIVES:: Cholecystokinin (CCK)-dependent exocrine pancreatic regulation seems to involve different pathways in different species. The aims were to explore the enteropancreatic reflex in the CCK-mediated regulation of the exocrine pancreas and to evaluate a possible involvement of this reflex in the endocrine insulin release. METHODS:: In anesthetized pigs, CCK-33 in increasing doses (4-130 pmol kg 10 min) was infused locally to the gastroduodenal artery, or systemically via the jugular vein. Also, a low CCK-33 dose (13 pmol kg) was injected to the duodenum/antrum area before and after a bilateral truncal vagotomy. RESULTS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min increased protein and trypsin outputs after local infusion to the antral-duodenal area, whereas it had no effect after systemic infusion. Cholecystokinin-33 in the pharmacological dose range 64 to 130 pmol kg 10 min further increased the secretion after both local and systemic infusions. Only CCK-33 infusions in the pharmacological dose range were able to elevate the plasma insulin levels. Vagotomy had no effect on CCK-33-mediated stimulation of the enzyme release, whereas it had a significant effect on the plasma insulin level. CONCLUSIONS:: Cholecystokinin-33 in the physiological dose range 4 to 32 pmol kg 10 min stimulates the enzyme secretion but had no effect on the insulin release via a short enteropancreatic pathway in pigs.},
  author       = {Rengman, Sofia and Weström, Björn and Ahrén, Bo and Pierzynowski, Stefan},
  issn         = {0885-3177},
  language     = {eng},
  pages        = {213--218},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pancreas},
  title        = {Arterial Gastroduodenal Infusion of Cholecystokinin-33 Stimulates the Exocrine Pancreatic Enzyme Release Via an Enteropancreatic Reflex, Without Affecting the Endocrine Insulin Secretion in Pigs.},
  url          = {http://dx.doi.org/10.1097/MPA.0b013e31818adf32},
  volume       = {38},
  year         = {2009},
}