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Cigarette smoking leads to reduced relaxant responses of the cutaneous microcirculation.

Edvinsson, MarieLouise LU ; Andersson, Sven LU ; Xu, Cang-Bao LU and Edvinsson, Lars LU (2008) In Vascular Health and Risk Management 4(3). p.699-704
Abstract
BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation. METHODS: The cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group. RESULTS: There was no difference between the groups in baseline characteristics or in basal flow.... (More)
BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation. METHODS: The cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group. RESULTS: There was no difference between the groups in baseline characteristics or in basal flow. Smokers showed however significantly reduced responses to both ACh (mean +/- SEM, from 973+/-137% in nonsmokers to 651+/-114% in smokers, p<0.05) and SNP (from 575+/-111% in nonsmokers to 355+/-83% in smokers, p<0.05). The response to the local heating (44 degrees C) was reduced in smokers (from 1188+/-215% in nonsmokers to 714+/-107% in smokers, p<0.01). In addition, there was no difference between men and women within the groups. CONCLUSIONS: The data show that cigarette smoking results in reduced peripheral microvascular responses to both endothelial and smooth muscle cell stimulation in healthy subjects, suggesting a generalized microvascular vasomotor function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Vasodilation: physiology, Smoking: physiopathology, Smoking: adverse effects, Skin: blood supply, Microcirculation: physiology, Acetylcholine: pharmacology, Vascular: physiopathology, Endothelium
in
Vascular Health and Risk Management
volume
4
issue
3
pages
699 - 704
publisher
Dove Press
external identifiers
  • pmid:18827920
  • scopus:47849086521
ISSN
1178-2048
language
English
LU publication?
yes
id
be4d42bb-cb76-4fee-a5e7-7151fc17c292 (old id 1262646)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18827920?dopt=Abstract
date added to LUP
2008-11-06 15:05:04
date last changed
2017-07-30 04:49:46
@article{be4d42bb-cb76-4fee-a5e7-7151fc17c292,
  abstract     = {BACKGROUND: Smoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation. METHODS: The cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group. RESULTS: There was no difference between the groups in baseline characteristics or in basal flow. Smokers showed however significantly reduced responses to both ACh (mean +/- SEM, from 973+/-137% in nonsmokers to 651+/-114% in smokers, p&lt;0.05) and SNP (from 575+/-111% in nonsmokers to 355+/-83% in smokers, p&lt;0.05). The response to the local heating (44 degrees C) was reduced in smokers (from 1188+/-215% in nonsmokers to 714+/-107% in smokers, p&lt;0.01). In addition, there was no difference between men and women within the groups. CONCLUSIONS: The data show that cigarette smoking results in reduced peripheral microvascular responses to both endothelial and smooth muscle cell stimulation in healthy subjects, suggesting a generalized microvascular vasomotor function.},
  author       = {Edvinsson, MarieLouise and Andersson, Sven and Xu, Cang-Bao and Edvinsson, Lars},
  issn         = {1178-2048},
  keyword      = {Vasodilation: physiology,Smoking: physiopathology,Smoking: adverse effects,Skin: blood supply,Microcirculation: physiology,Acetylcholine: pharmacology,Vascular: physiopathology,Endothelium},
  language     = {eng},
  number       = {3},
  pages        = {699--704},
  publisher    = {Dove Press},
  series       = {Vascular Health and Risk Management},
  title        = {Cigarette smoking leads to reduced relaxant responses of the cutaneous microcirculation.},
  volume       = {4},
  year         = {2008},
}