Advanced

Blood-brain barrier permeability and nerve cell damage in rat brain 14 and 28 days after exposure to microwaves from GSM mobile phones.

Eberhardt, Jacob LU ; Persson, Bertil R LU ; Brun, Arne LU ; Salford, Leif LU and Malmgren, Lars O G (2008) In Electromagnetic Biology and Medicine 27(3). p.215-229
Abstract
We investigated the effects of global system for mobile communication (GSM) microwave exposure on the permeability of the blood-brain barrier and signs of neuronal damage in rats using a real GSM programmable mobile phone in the 900 MHz band. Ninety-six non-anaesthetized rats were either exposed to microwaves or sham exposed in TEM-cells for 2 h at specific absorption rates of average whole-body Specific Absorption Rates (SAR) of 0.12, 1.2, 12, or 120 mW/kg. The rats were sacrificed after a recovery time of either 14 or 28 d, following exposure and the extravazation of albumin, its uptake into neurons, and occurrence of damaged neurons was assessed. Albumin extravazation and also its uptake into neurons was seen to be enhanced after 14 d... (More)
We investigated the effects of global system for mobile communication (GSM) microwave exposure on the permeability of the blood-brain barrier and signs of neuronal damage in rats using a real GSM programmable mobile phone in the 900 MHz band. Ninety-six non-anaesthetized rats were either exposed to microwaves or sham exposed in TEM-cells for 2 h at specific absorption rates of average whole-body Specific Absorption Rates (SAR) of 0.12, 1.2, 12, or 120 mW/kg. The rats were sacrificed after a recovery time of either 14 or 28 d, following exposure and the extravazation of albumin, its uptake into neurons, and occurrence of damaged neurons was assessed. Albumin extravazation and also its uptake into neurons was seen to be enhanced after 14 d (Kruskal Wallis test: p = 0.02 and 0.002, respectively), but not after a 28 d recovery period. The occurrence of dark neurons in the rat brains, on the other hand, was enhanced later, after 28 d (p = 0.02). Furthermore, in the 28-d brain samples, neuronal albumin uptake was significantly correlated to occurrence of damaged neurons (Spearman r = 0.41; p < 0.01). (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Electromagnetic Biology and Medicine
volume
27
issue
3
pages
215 - 229
publisher
Informa Healthcare
external identifiers
  • wos:000259541300002
  • pmid:18821198
  • scopus:52949091992
ISSN
1536-8386
DOI
10.1080/15368370802344037
language
English
LU publication?
yes
id
dcb5db30-8c76-437c-8c24-10e73f4ede53 (old id 1262772)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18821198?dopt=Abstract
date added to LUP
2008-11-06 11:45:49
date last changed
2017-07-09 04:33:02
@article{dcb5db30-8c76-437c-8c24-10e73f4ede53,
  abstract     = {We investigated the effects of global system for mobile communication (GSM) microwave exposure on the permeability of the blood-brain barrier and signs of neuronal damage in rats using a real GSM programmable mobile phone in the 900 MHz band. Ninety-six non-anaesthetized rats were either exposed to microwaves or sham exposed in TEM-cells for 2 h at specific absorption rates of average whole-body Specific Absorption Rates (SAR) of 0.12, 1.2, 12, or 120 mW/kg. The rats were sacrificed after a recovery time of either 14 or 28 d, following exposure and the extravazation of albumin, its uptake into neurons, and occurrence of damaged neurons was assessed. Albumin extravazation and also its uptake into neurons was seen to be enhanced after 14 d (Kruskal Wallis test: p = 0.02 and 0.002, respectively), but not after a 28 d recovery period. The occurrence of dark neurons in the rat brains, on the other hand, was enhanced later, after 28 d (p = 0.02). Furthermore, in the 28-d brain samples, neuronal albumin uptake was significantly correlated to occurrence of damaged neurons (Spearman r = 0.41; p &lt; 0.01).},
  author       = {Eberhardt, Jacob and Persson, Bertil R and Brun, Arne and Salford, Leif and Malmgren, Lars O G},
  issn         = {1536-8386},
  language     = {eng},
  number       = {3},
  pages        = {215--229},
  publisher    = {Informa Healthcare},
  series       = {Electromagnetic Biology and Medicine},
  title        = {Blood-brain barrier permeability and nerve cell damage in rat brain 14 and 28 days after exposure to microwaves from GSM mobile phones.},
  url          = {http://dx.doi.org/10.1080/15368370802344037},
  volume       = {27},
  year         = {2008},
}