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Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.

Ericsson, Ylva LU ; Tjörnstrand, Jon LU ; Tiderius, Carl Johan LU and Dahlberg, Leif LU (2009) In Osteoarthritis and Cartilage 17. p.565-570
Abstract
OBJECTIVE: To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS: Body mass index (BMI) was calculated in 45 patients (16 women), mean age 46, who underwent an arthroscopic medial meniscectomy 1-6 years earlier. The cartilage glycosaminoglycan (GAG) content was estimated by dGEMRIC Index and tests of isokinetic muscle strength and functional performance (one-leg hop test) were conducted. RESULTS: BMI ranged from 20.0 to 34.3 (mean: 26.5). The dGEMRIC Index was 14.4% lower in the medial index compartment (374+/-61ms, mean+/-SD) than in the lateral... (More)
OBJECTIVE: To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS: Body mass index (BMI) was calculated in 45 patients (16 women), mean age 46, who underwent an arthroscopic medial meniscectomy 1-6 years earlier. The cartilage glycosaminoglycan (GAG) content was estimated by dGEMRIC Index and tests of isokinetic muscle strength and functional performance (one-leg hop test) were conducted. RESULTS: BMI ranged from 20.0 to 34.3 (mean: 26.5). The dGEMRIC Index was 14.4% lower in the medial index compartment (374+/-61ms, mean+/-SD) than in the lateral reference compartment (437+/-59ms, mean+/-SD) (P<0.001). The dGEMRIC Index of the medial diseased compartment correlated positively with both knee flexor (r=0.50, P=0.001) and knee extensor strength (r=0.47, P=0.001) relative to body weight and with the one-leg hop test (r=0.42, P=0.004). Furthermore, a negative correlation was found between the dGEMRIC Index of the medial compartment and BMI (r=-0.35, P=0.019). No significant correlations were found in the lateral reference compartment. CONCLUSION: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early stage OA. Furthermore, results suggest that overweight is a factor that deteriorates cartilage, whereas strong and co-ordinated thigh muscles may have a protective effect on the cartilage integrity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Osteoarthritis and Cartilage
volume
17
pages
565 - 570
publisher
Elsevier
external identifiers
  • wos:000266139600003
  • pmid:19058980
  • scopus:64849099587
ISSN
1063-4584
DOI
10.1016/j.joca.2008.10.009
language
English
LU publication?
yes
id
0f3565ae-3987-4557-89d0-08c33e33524c (old id 1276411)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19058980?dopt=Abstract
date added to LUP
2009-01-09 08:57:49
date last changed
2017-09-10 04:44:27
@article{0f3565ae-3987-4557-89d0-08c33e33524c,
  abstract     = {OBJECTIVE: To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS: Body mass index (BMI) was calculated in 45 patients (16 women), mean age 46, who underwent an arthroscopic medial meniscectomy 1-6 years earlier. The cartilage glycosaminoglycan (GAG) content was estimated by dGEMRIC Index and tests of isokinetic muscle strength and functional performance (one-leg hop test) were conducted. RESULTS: BMI ranged from 20.0 to 34.3 (mean: 26.5). The dGEMRIC Index was 14.4% lower in the medial index compartment (374+/-61ms, mean+/-SD) than in the lateral reference compartment (437+/-59ms, mean+/-SD) (P&lt;0.001). The dGEMRIC Index of the medial diseased compartment correlated positively with both knee flexor (r=0.50, P=0.001) and knee extensor strength (r=0.47, P=0.001) relative to body weight and with the one-leg hop test (r=0.42, P=0.004). Furthermore, a negative correlation was found between the dGEMRIC Index of the medial compartment and BMI (r=-0.35, P=0.019). No significant correlations were found in the lateral reference compartment. CONCLUSION: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early stage OA. Furthermore, results suggest that overweight is a factor that deteriorates cartilage, whereas strong and co-ordinated thigh muscles may have a protective effect on the cartilage integrity.},
  author       = {Ericsson, Ylva and Tjörnstrand, Jon and Tiderius, Carl Johan and Dahlberg, Leif},
  issn         = {1063-4584},
  language     = {eng},
  pages        = {565--570},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.},
  url          = {http://dx.doi.org/10.1016/j.joca.2008.10.009},
  volume       = {17},
  year         = {2009},
}