Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.
(2009) In Osteoarthritis and Cartilage 17. p.565-570- Abstract
- OBJECTIVE: To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS: Body mass index (BMI) was calculated in 45 patients (16 women), mean age 46, who underwent an arthroscopic medial meniscectomy 1-6 years earlier. The cartilage glycosaminoglycan (GAG) content was estimated by dGEMRIC Index and tests of isokinetic muscle strength and functional performance (one-leg hop test) were conducted. RESULTS: BMI ranged from 20.0 to 34.3 (mean: 26.5). The dGEMRIC Index was 14.4% lower in the medial index compartment (374+/-61ms, mean+/-SD) than in the lateral... (More)
- OBJECTIVE: To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS: Body mass index (BMI) was calculated in 45 patients (16 women), mean age 46, who underwent an arthroscopic medial meniscectomy 1-6 years earlier. The cartilage glycosaminoglycan (GAG) content was estimated by dGEMRIC Index and tests of isokinetic muscle strength and functional performance (one-leg hop test) were conducted. RESULTS: BMI ranged from 20.0 to 34.3 (mean: 26.5). The dGEMRIC Index was 14.4% lower in the medial index compartment (374+/-61ms, mean+/-SD) than in the lateral reference compartment (437+/-59ms, mean+/-SD) (P<0.001). The dGEMRIC Index of the medial diseased compartment correlated positively with both knee flexor (r=0.50, P=0.001) and knee extensor strength (r=0.47, P=0.001) relative to body weight and with the one-leg hop test (r=0.42, P=0.004). Furthermore, a negative correlation was found between the dGEMRIC Index of the medial compartment and BMI (r=-0.35, P=0.019). No significant correlations were found in the lateral reference compartment. CONCLUSION: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early stage OA. Furthermore, results suggest that overweight is a factor that deteriorates cartilage, whereas strong and co-ordinated thigh muscles may have a protective effect on the cartilage integrity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1276411
- author
- Ericsson, Ylva LU ; Tjörnstrand, Jon LU ; Tiderius, Carl Johan LU and Dahlberg, Leif LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Osteoarthritis and Cartilage
- volume
- 17
- pages
- 565 - 570
- publisher
- Elsevier
- external identifiers
-
- wos:000266139600003
- pmid:19058980
- scopus:64849099587
- pmid:19058980
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2008.10.009
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300), Joint and Soft Tissue Unit (013242920), Clinical and Molecular Osteoporosis Research Unit (013242930)
- id
- 0f3565ae-3987-4557-89d0-08c33e33524c (old id 1276411)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19058980?dopt=Abstract
- date added to LUP
- 2016-04-04 07:49:05
- date last changed
- 2024-04-12 19:27:30
@article{0f3565ae-3987-4557-89d0-08c33e33524c, abstract = {{OBJECTIVE: To study the relationship between cartilage integrity, assessed with [delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC)] and epidemiologic risk factors for knee osteoarthritis (OA) in meniscectomized patients. METHODS: Body mass index (BMI) was calculated in 45 patients (16 women), mean age 46, who underwent an arthroscopic medial meniscectomy 1-6 years earlier. The cartilage glycosaminoglycan (GAG) content was estimated by dGEMRIC Index and tests of isokinetic muscle strength and functional performance (one-leg hop test) were conducted. RESULTS: BMI ranged from 20.0 to 34.3 (mean: 26.5). The dGEMRIC Index was 14.4% lower in the medial index compartment (374+/-61ms, mean+/-SD) than in the lateral reference compartment (437+/-59ms, mean+/-SD) (P<0.001). The dGEMRIC Index of the medial diseased compartment correlated positively with both knee flexor (r=0.50, P=0.001) and knee extensor strength (r=0.47, P=0.001) relative to body weight and with the one-leg hop test (r=0.42, P=0.004). Furthermore, a negative correlation was found between the dGEMRIC Index of the medial compartment and BMI (r=-0.35, P=0.019). No significant correlations were found in the lateral reference compartment. CONCLUSION: The lower dGEMRIC Index of the medial compartment suggests decreased cartilage GAG content after medial meniscectomy, indicating an early stage OA. Furthermore, results suggest that overweight is a factor that deteriorates cartilage, whereas strong and co-ordinated thigh muscles may have a protective effect on the cartilage integrity.}}, author = {{Ericsson, Ylva and Tjörnstrand, Jon and Tiderius, Carl Johan and Dahlberg, Leif}}, issn = {{1063-4584}}, language = {{eng}}, pages = {{565--570}}, publisher = {{Elsevier}}, series = {{Osteoarthritis and Cartilage}}, title = {{Relationship between cartilage glycosaminoglycan content (assessed with dGEMRIC) and OA risk factors in meniscectomized patients.}}, url = {{http://dx.doi.org/10.1016/j.joca.2008.10.009}}, doi = {{10.1016/j.joca.2008.10.009}}, volume = {{17}}, year = {{2009}}, }