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MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

Lindholm, Paivi; Peranen, Johan; Andressoo, Jaan-Olle; Kalkkinen, Nisse; Kokaia, Zaal LU ; Lindvall, Olle LU ; Timmusk, Tonis and Saarma, Mart (2008) In Molecular and Cellular Neuroscience 39(3). p.356-371
Abstract
The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been described as a Survival factor for dopaminergic neurons in vitro, but its expression in mammalian tissues is poorly known. MANF and a homologous Protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. Here we used in situ hybridization and immunohistochemistry to characterize MANF expression in developing and adult mouse. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. After status epilepticus, Manf mRNA expression was transiently increased in the... (More)
The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been described as a Survival factor for dopaminergic neurons in vitro, but its expression in mammalian tissues is poorly known. MANF and a homologous Protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. Here we used in situ hybridization and immunohistochemistry to characterize MANF expression in developing and adult mouse. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. After status epilepticus, Manf mRNA expression was transiently increased in the dentate granule cell layer of hippocampus, thalamic reticular nucleus and in several cortical areas. In contrast, following global forebrain ischemia changes in Manf expression were widespread in the hippocampal formation and more restricted in cerebral cortex. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types. (C) 2008 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Status epilepticus, Ischemia, Immunohistochemistry, Expression, Dopaminergic, CDNF, MANF, ARMET
in
Molecular and Cellular Neuroscience
volume
39
issue
3
pages
356 - 371
publisher
Elsevier
external identifiers
  • wos:000260607600007
  • scopus:53849102168
ISSN
1044-7431
DOI
10.1016/j.mcn.2008.07.016
language
English
LU publication?
yes
id
4d76ea45-4392-45ca-957c-aa787fed46fa (old id 1282977)
date added to LUP
2009-02-10 13:41:11
date last changed
2017-11-05 03:39:37
@article{4d76ea45-4392-45ca-957c-aa787fed46fa,
  abstract     = {The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been described as a Survival factor for dopaminergic neurons in vitro, but its expression in mammalian tissues is poorly known. MANF and a homologous Protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. Here we used in situ hybridization and immunohistochemistry to characterize MANF expression in developing and adult mouse. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. After status epilepticus, Manf mRNA expression was transiently increased in the dentate granule cell layer of hippocampus, thalamic reticular nucleus and in several cortical areas. In contrast, following global forebrain ischemia changes in Manf expression were widespread in the hippocampal formation and more restricted in cerebral cortex. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types. (C) 2008 Elsevier Inc. All rights reserved.},
  author       = {Lindholm, Paivi and Peranen, Johan and Andressoo, Jaan-Olle and Kalkkinen, Nisse and Kokaia, Zaal and Lindvall, Olle and Timmusk, Tonis and Saarma, Mart},
  issn         = {1044-7431},
  keyword      = {Status epilepticus,Ischemia,Immunohistochemistry,Expression,Dopaminergic,CDNF,MANF,ARMET},
  language     = {eng},
  number       = {3},
  pages        = {356--371},
  publisher    = {Elsevier},
  series       = {Molecular and Cellular Neuroscience},
  title        = {MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain},
  url          = {http://dx.doi.org/10.1016/j.mcn.2008.07.016},
  volume       = {39},
  year         = {2008},
}