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Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media

Xu, Can LU ; Svensson, Niclas; Axelsson, Johan LU ; Svenmarker, Pontus LU ; Somesfalean, Gabriel LU ; Chen, Guanying; Liang, Huijuan; Liu, Haichun; Zhang, Zhiguo and Andersson-Engels, Stefan LU (2008) In Applied Physics Letters 93(17).
Abstract
Autofluorescence is a nuisance in the field of fluorescence imaging and tomography of exogenous molecular markers in tissue, degrading the quality of the collected data. In this letter, we report autofluorescence insensitive imaging using highly efficient upconverting nanocrystals (NaYF4: Yb3+ /Tm3+) in a tissue phantom illuminated with near- infrared radiation of 85 mW/cm(2). It was found that imaging with such nanocrystals leads to an exceptionally high contrast compared to traditional downconverting fluorophores due to the absence of autofluorescence. Upconverting nanocrystals may be envisaged as important biological markers for tissue imaging purposes. c 2008 American Institute of Physics. [DOI: 10.1063/1.3005588]
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Physics Letters
volume
93
issue
17
publisher
American Institute of Physics
external identifiers
  • wos:000260571800003
  • scopus:55149103100
ISSN
0003-6951
DOI
10.1063/1.3005588
language
English
LU publication?
yes
id
8154a135-dd78-48ef-94be-855b7d48161f (old id 1283683)
date added to LUP
2009-02-10 10:26:44
date last changed
2017-09-17 04:30:17
@article{8154a135-dd78-48ef-94be-855b7d48161f,
  abstract     = {Autofluorescence is a nuisance in the field of fluorescence imaging and tomography of exogenous molecular markers in tissue, degrading the quality of the collected data. In this letter, we report autofluorescence insensitive imaging using highly efficient upconverting nanocrystals (NaYF4: Yb3+ /Tm3+) in a tissue phantom illuminated with near- infrared radiation of 85 mW/cm(2). It was found that imaging with such nanocrystals leads to an exceptionally high contrast compared to traditional downconverting fluorophores due to the absence of autofluorescence. Upconverting nanocrystals may be envisaged as important biological markers for tissue imaging purposes. c 2008 American Institute of Physics. [DOI: 10.1063/1.3005588]},
  author       = {Xu, Can and Svensson, Niclas and Axelsson, Johan and Svenmarker, Pontus and Somesfalean, Gabriel and Chen, Guanying and Liang, Huijuan and Liu, Haichun and Zhang, Zhiguo and Andersson-Engels, Stefan},
  issn         = {0003-6951},
  language     = {eng},
  number       = {17},
  publisher    = {American Institute of Physics},
  series       = {Applied Physics Letters},
  title        = {Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media},
  url          = {http://dx.doi.org/10.1063/1.3005588},
  volume       = {93},
  year         = {2008},
}