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Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

Crusius, J. B. A.; Canzian, F.; Capella, G.; Pena, A. S.; Pera, G.; Sala, N.; Agudo, A.; Rico, F.; Del Giudice, G. and Palli, D., et al. (2008) In Annals of Oncology 19(11). p.1894-1902
Abstract
Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN2R/2R genotype [odds ratio (OR) 2.43; 95% confidence... (More)
Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RNEx5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T > A may modify the risk for GC. (Less)
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publication status
published
subject
keywords
cytokine genes, polymorphisms, atrophic gastritis, severe chronic, gastric carcinoma
in
Annals of Oncology
volume
19
issue
11
pages
1894 - 1902
publisher
Oxford University Press
external identifiers
  • wos:000260381100012
  • scopus:54949110598
ISSN
1569-8041
DOI
10.1093/annonc/mdn400
language
English
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yes
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15a8351a-ea67-4345-ab24-a2a88052fbcf (old id 1285021)
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2009-02-06 11:16:25
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2017-09-10 03:57:24
@article{15a8351a-ea67-4345-ab24-a2a88052fbcf,
  abstract     = {Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin alpha and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RNEx5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF -487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T > A may modify the risk for GC.},
  author       = {Crusius, J. B. A. and Canzian, F. and Capella, G. and Pena, A. S. and Pera, G. and Sala, N. and Agudo, A. and Rico, F. and Del Giudice, G. and Palli, D. and Plebani, M. and Boeing, H. and Bueno-de-Mesquita, H. B. and Carneiro, F. and Pala, V. and Save, V. E. and Vineis, P. and Tumino, R. and Panico, S. and Berglund, Göran and Manjer, J. and Stenling, R. and Hallmans, G. and Martinez, C. and Dorronsoro, M. and Barricarte, A. and Navarro, C. and Quiros, J. R. and Allen, N. and Key, T. J. and Binghan, S. and Caldas, C. and Linseisen, J. and Kaaks, R. and Overvad, K. and Tjonneland, A. and Buechner, F. C. and Peeters, P. H. M. and Numans, M. E. and Clavel-Chapelon, F. and Trichopoulou, A. and Lund, E. and Jenab, M. and Rinaldi, S. and Ferrari, P. and Riboli, E. and Gonzalez, C. A.},
  issn         = {1569-8041},
  keyword      = {cytokine genes,polymorphisms,atrophic gastritis,severe chronic,gastric carcinoma},
  language     = {eng},
  number       = {11},
  pages        = {1894--1902},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)},
  url          = {http://dx.doi.org/10.1093/annonc/mdn400},
  volume       = {19},
  year         = {2008},
}