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Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study

Peluso, Marco; Alroldi, Luisa; Munnia, Armelle; Colombi, Alessandro; Veglia, Fabrizio; Autrup, Herman; Dunning, Alison; Garte, Seymour; Gormally, Emmanuelle and Malaveille, Christian, et al. (2008) In British Journal of Nutrition 100(3). p.489-495
Abstract
In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were... (More)
In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse. statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P=0.02), vitamin E (P =0.04) and alcohol (P=0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P=0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but Such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances. (Less)
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published
subject
keywords
air, fibre intake, non-smokers, DNA adducts, haemoglobin adducts, pollution
in
British Journal of Nutrition
volume
100
issue
3
pages
489 - 495
publisher
Cambridge University Press
external identifiers
  • wos:000259677300005
  • scopus:49649087287
ISSN
1475-2662
DOI
10.1017/S0007114508911600
language
English
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yes
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52ed1f9b-7577-45a0-894d-b07ae9732280 (old id 1286085)
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2009-02-04 10:01:16
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2017-07-02 03:33:41
@article{52ed1f9b-7577-45a0-894d-b07ae9732280,
  abstract     = {In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse. statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P=0.02), vitamin E (P =0.04) and alcohol (P=0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P=0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but Such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances.},
  author       = {Peluso, Marco and Alroldi, Luisa and Munnia, Armelle and Colombi, Alessandro and Veglia, Fabrizio and Autrup, Herman and Dunning, Alison and Garte, Seymour and Gormally, Emmanuelle and Malaveille, Christian and Matullo, Giuseppe and Overvad, Kim and Raaschou-Nielsen, Ole and Clavel-Chapelon, Francoise and Linseisen, Jacob and Boeing, Heiner and Trichopoulou, Antonia and Palli, Domenico and Krogh, Vittorio and Tumino, Rosario and Panico, Salvatore and Bueno-De-Mesquita, Bas H. and Peeters, Petra H. and Kumle, Merethe and Agudo, Antonio and Martinez, Carmen and Dorronsoro, Miren and Barricarte, Aurelio and Tormo, Maria Jose and Quiros, Jose Ramon and Berglund, Göran and Jarvholm, Bengt and Day, Nicholas E. and Key, Timothy J. and Saracci, Rodolfo and Kaaks, Rudolf and Riboli, Elio and Bingham, Shelia and Vineis, Paolo},
  issn         = {1475-2662},
  keyword      = {air,fibre intake,non-smokers,DNA adducts,haemoglobin adducts,pollution},
  language     = {eng},
  number       = {3},
  pages        = {489--495},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study},
  url          = {http://dx.doi.org/10.1017/S0007114508911600},
  volume       = {100},
  year         = {2008},
}