Incretin and islet hormonal responses to fat and protein ingestion in healthy men
(2008) In American Journal of Physiology: Endocrinology and Metabolism 295(4). p.779-784- Abstract
- Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet function after carbohydrate ingestion. Whether incretin hormones are of importance for islet function after ingestion of noncarbohydrate macronutrients is not known. This study therefore examined integrated incretin and islet hormone responses to ingestion of pure fat (oleic acid; 0.88 g/kg) or protein (milk and egg protein; 2 g/kg) over 5 h in healthy men, aged 20-25 yr (n = 12); plain water ingestion served as control. Both intact (active) and total GLP-1 and GIP levels were determined as was plasma activity of dipeptidyl peptidase-4 (DPP-4). Following water ingestion, glucose, insulin, glucagon, GLP-1, and GIP levels and DPP-4 activity... (More)
- Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet function after carbohydrate ingestion. Whether incretin hormones are of importance for islet function after ingestion of noncarbohydrate macronutrients is not known. This study therefore examined integrated incretin and islet hormone responses to ingestion of pure fat (oleic acid; 0.88 g/kg) or protein (milk and egg protein; 2 g/kg) over 5 h in healthy men, aged 20-25 yr (n = 12); plain water ingestion served as control. Both intact (active) and total GLP-1 and GIP levels were determined as was plasma activity of dipeptidyl peptidase-4 (DPP-4). Following water ingestion, glucose, insulin, glucagon, GLP-1, and GIP levels and DPP-4 activity were stable during the 5-h study period. Both fat and protein ingestion increased insulin, glucagon, GIP, and GLP-1 levels without affecting glucose levels or DPP-4 activity. The GLP-1 responses were similar after protein and fat, whereas the early (30 min) GIP response was higher after protein than after fat ingestion (P < 0.001). This was associated with sevenfold higher insulin and glucagon responses compared with fat ingestion (both P < 0.001). After protein, the early GIP, but not GLP-1, responses correlated to insulin (r(2) = 0.86; P = 0.0001) but not glucagon responses. In contrast, after fat ingestion, GLP-1 and GIP did not correlate to islet hormones. We conclude that, whereas protein and fat release both incretin and islet hormones, the early GIP secretion after protein ingestion may be of primary importance to islet hormone secretion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1286136
- author
- Carr, Richard D. ; Larsen, Marianne O. ; Sörhede Winzell, Maria LU ; Jelic, Katarina ; Lindgren, Ola LU ; Deacon, Carolyn F. and Ahrén, Bo LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- incretins, glucagon-like peptide-1, man, glucose-dependent, insulinotropic polypeptide, insulin, glucagon
- in
- American Journal of Physiology: Endocrinology and Metabolism
- volume
- 295
- issue
- 4
- pages
- 779 - 784
- publisher
- American Physiological Society
- external identifiers
-
- wos:000259967600006
- scopus:56049105157
- pmid:18612044
- ISSN
- 1522-1555
- DOI
- 10.1152/ajpendo.90233.2008
- language
- English
- LU publication?
- yes
- id
- 2c49784c-d53a-4b76-a92e-e2d3738f1439 (old id 1286136)
- date added to LUP
- 2016-04-01 14:12:06
- date last changed
- 2024-02-25 11:33:15
@article{2c49784c-d53a-4b76-a92e-e2d3738f1439,
abstract = {{Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) regulate islet function after carbohydrate ingestion. Whether incretin hormones are of importance for islet function after ingestion of noncarbohydrate macronutrients is not known. This study therefore examined integrated incretin and islet hormone responses to ingestion of pure fat (oleic acid; 0.88 g/kg) or protein (milk and egg protein; 2 g/kg) over 5 h in healthy men, aged 20-25 yr (n = 12); plain water ingestion served as control. Both intact (active) and total GLP-1 and GIP levels were determined as was plasma activity of dipeptidyl peptidase-4 (DPP-4). Following water ingestion, glucose, insulin, glucagon, GLP-1, and GIP levels and DPP-4 activity were stable during the 5-h study period. Both fat and protein ingestion increased insulin, glucagon, GIP, and GLP-1 levels without affecting glucose levels or DPP-4 activity. The GLP-1 responses were similar after protein and fat, whereas the early (30 min) GIP response was higher after protein than after fat ingestion (P < 0.001). This was associated with sevenfold higher insulin and glucagon responses compared with fat ingestion (both P < 0.001). After protein, the early GIP, but not GLP-1, responses correlated to insulin (r(2) = 0.86; P = 0.0001) but not glucagon responses. In contrast, after fat ingestion, GLP-1 and GIP did not correlate to islet hormones. We conclude that, whereas protein and fat release both incretin and islet hormones, the early GIP secretion after protein ingestion may be of primary importance to islet hormone secretion.}},
author = {{Carr, Richard D. and Larsen, Marianne O. and Sörhede Winzell, Maria and Jelic, Katarina and Lindgren, Ola and Deacon, Carolyn F. and Ahrén, Bo}},
issn = {{1522-1555}},
keywords = {{incretins; glucagon-like peptide-1; man; glucose-dependent; insulinotropic polypeptide; insulin; glucagon}},
language = {{eng}},
number = {{4}},
pages = {{779--784}},
publisher = {{American Physiological Society}},
series = {{American Journal of Physiology: Endocrinology and Metabolism}},
title = {{Incretin and islet hormonal responses to fat and protein ingestion in healthy men}},
url = {{http://dx.doi.org/10.1152/ajpendo.90233.2008}},
doi = {{10.1152/ajpendo.90233.2008}},
volume = {{295}},
year = {{2008}},
}