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The Bcl-xL inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma.

Vasiljevic, Natasa LU ; Andersson, Kristin LU ; Bjelkenkrantz, Kaj; Kjellström, Christer; Månsson, Henrik LU ; Nilsson, Elise LU ; Landberg, Göran LU ; Dillner, Joakim LU and Forslund, Ola LU (2009) In International Journal of Cancer 124. p.2361-2366
Abstract
Keratoacanthoma (KA) is difficult to histologically distinguish from squamous cell carcinoma (SCC). Therefore, although KA is a benign self-resolving skin lesion, KA is commonly treated as SCC. Biomarkers to distinguish KA and SCC would thus be desirable. In search for specific markers, paraffin-embedded tissue samples from 25 SCC and 64 KA were arranged in a tissue microarray (TMA) and stained for immunologic cell-markers CD3, CD20 and CD68 as well as for proteins considered of relevance in tumorgenesis, namely NFkappaB/p65, IkappaB-alpha, STAT3, p53, TRAP-1, pRB, phosphorylated pRb, Cyld, p21, p16(INK4), Survivin, Bcl-xL, Caspase 3, Bak, FLK-1/VEGF-r2 and Ki-67. In addition, the tumors were tested for presence of human papillomavirus by... (More)
Keratoacanthoma (KA) is difficult to histologically distinguish from squamous cell carcinoma (SCC). Therefore, although KA is a benign self-resolving skin lesion, KA is commonly treated as SCC. Biomarkers to distinguish KA and SCC would thus be desirable. In search for specific markers, paraffin-embedded tissue samples from 25 SCC and 64 KA were arranged in a tissue microarray (TMA) and stained for immunologic cell-markers CD3, CD20 and CD68 as well as for proteins considered of relevance in tumorgenesis, namely NFkappaB/p65, IkappaB-alpha, STAT3, p53, TRAP-1, pRB, phosphorylated pRb, Cyld, p21, p16(INK4), Survivin, Bcl-xL, Caspase 3, Bak, FLK-1/VEGF-r2 and Ki-67. In addition, the tumors were tested for presence of human papillomavirus by PCR. We detected that the two lesions differed significantly in expression of Bcl-xL which was present in 84% of the SCC compared with only 15% in the KA (p < 0.001). The lower expression of the antiapoptotic protein Bcl-xL in KA is consistent with a possible role of apoptosis in the regression of KA. (c) 2008 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
124
pages
2361 - 2366
publisher
John Wiley & Sons
external identifiers
  • wos:000265353200013
  • pmid:19165861
  • scopus:64249086910
ISSN
0020-7136
DOI
10.1002/ijc.24197
language
English
LU publication?
yes
id
af11b3be-50d8-49ac-97b3-82bcd9116d0f (old id 1289315)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19165861?dopt=Abstract
date added to LUP
2009-02-05 14:36:42
date last changed
2017-08-06 04:48:19
@article{af11b3be-50d8-49ac-97b3-82bcd9116d0f,
  abstract     = {Keratoacanthoma (KA) is difficult to histologically distinguish from squamous cell carcinoma (SCC). Therefore, although KA is a benign self-resolving skin lesion, KA is commonly treated as SCC. Biomarkers to distinguish KA and SCC would thus be desirable. In search for specific markers, paraffin-embedded tissue samples from 25 SCC and 64 KA were arranged in a tissue microarray (TMA) and stained for immunologic cell-markers CD3, CD20 and CD68 as well as for proteins considered of relevance in tumorgenesis, namely NFkappaB/p65, IkappaB-alpha, STAT3, p53, TRAP-1, pRB, phosphorylated pRb, Cyld, p21, p16(INK4), Survivin, Bcl-xL, Caspase 3, Bak, FLK-1/VEGF-r2 and Ki-67. In addition, the tumors were tested for presence of human papillomavirus by PCR. We detected that the two lesions differed significantly in expression of Bcl-xL which was present in 84% of the SCC compared with only 15% in the KA (p &lt; 0.001). The lower expression of the antiapoptotic protein Bcl-xL in KA is consistent with a possible role of apoptosis in the regression of KA. (c) 2008 Wiley-Liss, Inc.},
  author       = {Vasiljevic, Natasa and Andersson, Kristin and Bjelkenkrantz, Kaj and Kjellström, Christer and Månsson, Henrik and Nilsson, Elise and Landberg, Göran and Dillner, Joakim and Forslund, Ola},
  issn         = {0020-7136},
  language     = {eng},
  pages        = {2361--2366},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {The Bcl-xL inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma.},
  url          = {http://dx.doi.org/10.1002/ijc.24197},
  volume       = {124},
  year         = {2009},
}