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Hoarseness as a Sign of Possible Nonspecific Mucosal Hyperreactivity in Vocal Tract.

Lyberg Åhlander, Viveka LU ; Malm, Lars LU and Schalén, Lucyna LU (2009) In Journal of voice : official journal of the Voice Foundation 23. p.707-715
Abstract
The aim of the present paper was to evaluate the possible impact of methacholine challenge on the voice and vocal tract in 10 patients reporting hoarseness due to presumable hyperreactivity to some environmental factors. Ten age and gender-matched healthy subjects served as controls. Methacholine was used for hypersensitivity challenge and saline solution (0.9% NaCl) as control substance. Subjects were examined on two separate challenge occasions testing either methacholine in increasing doses (3, 6, 12 mg) or NaCl. Voice recordings, videolaryngoscopy, and measurement of nasal secretion were performed before and after each sniffing session. Subjective complaints were documented. Data were statistically analyzed with three-way analysis of... (More)
The aim of the present paper was to evaluate the possible impact of methacholine challenge on the voice and vocal tract in 10 patients reporting hoarseness due to presumable hyperreactivity to some environmental factors. Ten age and gender-matched healthy subjects served as controls. Methacholine was used for hypersensitivity challenge and saline solution (0.9% NaCl) as control substance. Subjects were examined on two separate challenge occasions testing either methacholine in increasing doses (3, 6, 12 mg) or NaCl. Voice recordings, videolaryngoscopy, and measurement of nasal secretion were performed before and after each sniffing session. Subjective complaints were documented. Data were statistically analyzed with three-way analysis of variance and group comparisons performed. Perceptual analysis of voice recordings showed an increase of the grade of voice disorder in patients after exposure to both substances. Moreover, one of the patients became aphonic and another severely dysphonic after NaCl. No voice quality changes were detected in controls. The videolaryngoscopy findings divergent from normal did not increase in any group. Nasal secretion was significantly higher after sniffing of methacholine than NaCl in both groups. The frequency of subjective complaints was equal in both groups after both substances. However, there was a qualitative difference in the character of the symptoms: the patients complained of throat, vocal, and nasal symptoms whereas the controls complained exclusively of nasal symptoms. The study supports the view that vocal dysfunction after exposure to non-specific environmental irritating factors may be triggered mainly by emotional mechanisms such as off-warding reaction or dissociative disorder. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of voice : official journal of the Voice Foundation
volume
23
pages
707 - 715
publisher
Elsevier
external identifiers
  • wos:000271777500010
  • pmid:19135855
  • scopus:70350565509
ISSN
1557-8658
DOI
10.1016/j.jvoice.2008.04.007
language
English
LU publication?
yes
id
4792dc49-9809-411a-b258-cec73ba64023 (old id 1289802)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19135855?dopt=Abstract
date added to LUP
2009-02-03 10:46:13
date last changed
2017-01-01 07:50:30
@article{4792dc49-9809-411a-b258-cec73ba64023,
  abstract     = {The aim of the present paper was to evaluate the possible impact of methacholine challenge on the voice and vocal tract in 10 patients reporting hoarseness due to presumable hyperreactivity to some environmental factors. Ten age and gender-matched healthy subjects served as controls. Methacholine was used for hypersensitivity challenge and saline solution (0.9% NaCl) as control substance. Subjects were examined on two separate challenge occasions testing either methacholine in increasing doses (3, 6, 12 mg) or NaCl. Voice recordings, videolaryngoscopy, and measurement of nasal secretion were performed before and after each sniffing session. Subjective complaints were documented. Data were statistically analyzed with three-way analysis of variance and group comparisons performed. Perceptual analysis of voice recordings showed an increase of the grade of voice disorder in patients after exposure to both substances. Moreover, one of the patients became aphonic and another severely dysphonic after NaCl. No voice quality changes were detected in controls. The videolaryngoscopy findings divergent from normal did not increase in any group. Nasal secretion was significantly higher after sniffing of methacholine than NaCl in both groups. The frequency of subjective complaints was equal in both groups after both substances. However, there was a qualitative difference in the character of the symptoms: the patients complained of throat, vocal, and nasal symptoms whereas the controls complained exclusively of nasal symptoms. The study supports the view that vocal dysfunction after exposure to non-specific environmental irritating factors may be triggered mainly by emotional mechanisms such as off-warding reaction or dissociative disorder.},
  author       = {Lyberg Åhlander, Viveka and Malm, Lars and Schalén, Lucyna},
  issn         = {1557-8658},
  language     = {eng},
  pages        = {707--715},
  publisher    = {Elsevier},
  series       = {Journal of voice : official journal of the Voice Foundation},
  title        = {Hoarseness as a Sign of Possible Nonspecific Mucosal Hyperreactivity in Vocal Tract.},
  url          = {http://dx.doi.org/10.1016/j.jvoice.2008.04.007},
  volume       = {23},
  year         = {2009},
}