Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019 : a population-based study
(2023) In Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 28(10). p.1-10- Abstract
BackgroundBloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.MethodsWe retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.ResultsWe identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication... (More)
BackgroundBloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.MethodsWe retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.ResultsWe identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication and removal of contaminants, 54,498 separate BSI episodes remained. In total, 30,003 BSI episodes (55%) occurred in men. The overall IR of BSI was 307/100,000 person-years, with an average annual increase of 3.0%. Persons ≥ 80 years had the highest IR, 1781/100,000 person-years, as well as the largest increase. Escherichia coli (27%) and Staphylococcus aureus (13%) were the most frequent findings. The proportion of Enterobacterales isolates resistant to fluoroquinolones and third generation cephalosporins increased from 8.4% to 13.6%, and 4.9% to 7.3%, (p for trend < 0.001), with the largest increase in the oldest age group.ConclusionWe report among the highest BSI IRs to date worldwide, with a higher proportion among elderly persons and males, including resistant isolates. Given expected demographic changes, these results indicate a possible substantial future BSI burden, for which preventive measures are needed.
(Less)
- author
- Ljungquist, Oskar LU ; Blomstergren, Adam LU ; Merkel, Adam ; Sunnerhagen, Torgny LU ; Holm, Karin LU and Torisson, Gustav LU
- organization
- publishing date
- 2023-03-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- volume
- 28
- issue
- 10
- pages
- 1 - 10
- publisher
- European Centre for Disease Prevention and Control (ECDC)
- external identifiers
-
- scopus:85150001321
- pmid:36892472
- ISSN
- 1560-7917
- DOI
- 10.2807/1560-7917.ES.2023.28.10.2200519
- language
- English
- LU publication?
- yes
- id
- 12b79da9-f8d4-4d93-b6a2-c2a12da26828
- alternative location
- https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.10.2200519
- date added to LUP
- 2023-03-09 21:07:54
- date last changed
- 2024-09-08 08:43:16
@article{12b79da9-f8d4-4d93-b6a2-c2a12da26828, abstract = {{<p>BackgroundBloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.MethodsWe retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.ResultsWe identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication and removal of contaminants, 54,498 separate BSI episodes remained. In total, 30,003 BSI episodes (55%) occurred in men. The overall IR of BSI was 307/100,000 person-years, with an average annual increase of 3.0%. Persons ≥ 80 years had the highest IR, 1781/100,000 person-years, as well as the largest increase. Escherichia coli (27%) and Staphylococcus aureus (13%) were the most frequent findings. The proportion of Enterobacterales isolates resistant to fluoroquinolones and third generation cephalosporins increased from 8.4% to 13.6%, and 4.9% to 7.3%, (p for trend < 0.001), with the largest increase in the oldest age group.ConclusionWe report among the highest BSI IRs to date worldwide, with a higher proportion among elderly persons and males, including resistant isolates. Given expected demographic changes, these results indicate a possible substantial future BSI burden, for which preventive measures are needed.</p>}}, author = {{Ljungquist, Oskar and Blomstergren, Adam and Merkel, Adam and Sunnerhagen, Torgny and Holm, Karin and Torisson, Gustav}}, issn = {{1560-7917}}, language = {{eng}}, month = {{03}}, number = {{10}}, pages = {{1--10}}, publisher = {{European Centre for Disease Prevention and Control (ECDC)}}, series = {{Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin}}, title = {{Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019 : a population-based study}}, url = {{https://lup.lub.lu.se/search/files/140010104/eurosurv_28_10_4.pdf}}, doi = {{10.2807/1560-7917.ES.2023.28.10.2200519}}, volume = {{28}}, year = {{2023}}, }