Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019 : a population-based study
Ljungquist, Oskar LU ; Blomstergren, Adam LU ; Merkel, Adam ; Sunnerhagen, Torgny LU
; Holm, Karin
LU
and Torisson, Gustav
LU
(2023)
In Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
28(10).
p.1-10
- Abstract
Background
Bloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.
Methods
We retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.
Results
We identified 944,375 blood culture sets, and 129,274 (13.7%)... (More)
Background
Bloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.
Methods
We retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.
Results
We identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication and removal of contaminants, 54,498 separate BSI episodes remained. In total, 30,003 BSI episodes (55%) occurred in men. The overall IR of BSI was 307/100,000 person-years, with an average annual increase of 3.0%. Persons ≥ 80 years had the highest IR, 1781/100,000 person-years, as well as the largest increase. Escherichia coli (27%) and Staphylococcus aureus (13%) were the most frequent findings. The proportion of Enterobacterales isolates resistant to fluoroquinolones and third generation cephalosporins increased from 8.4% to 13.6%, and 4.9% to 7.3%, (p for trend < 0.001), with the largest increase in the oldest age group.
Conclusion
We report among the highest BSI IRs to date worldwide, with a higher proportion among elderly persons and males, including resistant isolates. Given expected demographic changes, these results indicate a possible substantial future BSI burden, for which preventive measures are needed.
(Less)
- author
- Ljungquist, Oskar
LU
; Blomstergren, Adam
LU
; Merkel, Adam
; Sunnerhagen, Torgny
LU
; Holm, Karin
LU
and Torisson, Gustav
LU
- organization
- publishing date
- 2023-03-09
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- volume
- 28
- issue
- 10
- pages
- 1 - 10
- publisher
- European Centre for Disease Prevention and Control (ECDC)
- external identifiers
-
- pmid:36892472
- scopus:85150001321
- ISSN
- 1560-7917
- DOI
- 10.2807/1560-7917.ES.2023.28.10.2200519
- language
- English
- LU publication?
- yes
- id
- 12b79da9-f8d4-4d93-b6a2-c2a12da26828
- alternative location
- https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.10.2200519
- date added to LUP
- 2023-03-09 21:07:54
- date last changed
- 2026-06-30 00:45:25
@article{12b79da9-f8d4-4d93-b6a2-c2a12da26828,
abstract = {{<p>Background</p><p>Bloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.</p><p>Methods</p><p>We retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.</p><p>Results</p><p>We identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication and removal of contaminants, 54,498 separate BSI episodes remained. In total, 30,003 BSI episodes (55%) occurred in men. The overall IR of BSI was 307/100,000 person-years, with an average annual increase of 3.0%. Persons ≥ 80 years had the highest IR, 1781/100,000 person-years, as well as the largest increase. <i>Escherichia coli </i>(27%) and <i>Staphylococcus aureus </i>(13%) were the most frequent findings. The proportion of Enterobacterales isolates resistant to fluoroquinolones and third generation cephalosporins increased from 8.4% to 13.6%, and 4.9% to 7.3%, (p for trend < 0.001), with the largest increase in the oldest age group.</p><p>Conclusion</p><p>We report among the highest BSI IRs to date worldwide, with a higher proportion among elderly persons and males, including resistant isolates. Given expected demographic changes, these results indicate a possible substantial future BSI burden, for which preventive measures are needed.</p>}},
author = {{Ljungquist, Oskar and Blomstergren, Adam and Merkel, Adam and Sunnerhagen, Torgny and Holm, Karin and Torisson, Gustav}},
issn = {{1560-7917}},
language = {{eng}},
month = {{03}},
number = {{10}},
pages = {{1--10}},
publisher = {{European Centre for Disease Prevention and Control (ECDC)}},
series = {{Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin}},
title = {{Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019 : a population-based study}},
url = {{https://lup.lub.lu.se/search/files/140010104/eurosurv_28_10_4.pdf}},
doi = {{10.2807/1560-7917.ES.2023.28.10.2200519}},
volume = {{28}},
year = {{2023}},
}