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Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019 : a population-based study

Ljungquist, Oskar LU ; Blomstergren, Adam LU ; Merkel, Adam ; Sunnerhagen, Torgny LU orcid ; Holm, Karin LU and Torisson, Gustav LU orcid (2023) In Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 28(10). p.1-10
Abstract

BackgroundBloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.MethodsWe retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.ResultsWe identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication... (More)

BackgroundBloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.MethodsWe retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.ResultsWe identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication and removal of contaminants, 54,498 separate BSI episodes remained. In total, 30,003 BSI episodes (55%) occurred in men. The overall IR of BSI was 307/100,000 person-years, with an average annual increase of 3.0%. Persons ≥ 80 years had the highest IR, 1781/100,000 person-years, as well as the largest increase. Escherichia coli (27%) and Staphylococcus aureus (13%) were the most frequent findings. The proportion of Enterobacterales isolates resistant to fluoroquinolones and third generation cephalosporins increased from 8.4% to 13.6%, and 4.9% to 7.3%, (p for trend < 0.001), with the largest increase in the oldest age group.ConclusionWe report among the highest BSI IRs to date worldwide, with a higher proportion among elderly persons and males, including resistant isolates. Given expected demographic changes, these results indicate a possible substantial future BSI burden, for which preventive measures are needed.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
volume
28
issue
10
pages
1 - 10
publisher
European Centre for Disease Prevention and Control (ECDC)
external identifiers
  • scopus:85150001321
  • pmid:36892472
ISSN
1560-7917
DOI
10.2807/1560-7917.ES.2023.28.10.2200519
language
English
LU publication?
yes
id
12b79da9-f8d4-4d93-b6a2-c2a12da26828
alternative location
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2023.28.10.2200519
date added to LUP
2023-03-09 21:07:54
date last changed
2024-06-16 04:09:50
@article{12b79da9-f8d4-4d93-b6a2-c2a12da26828,
  abstract     = {{<p>BackgroundBloodstream infections (BSI) are a public health concern, and infections caused by resistant bacteria further increase the overall BSI burden on healthcare.AimTo provide a population-based estimate of BSI incidence and relate this to the forthcoming demographic ageing western population change.MethodsWe retrieved positive blood cultures taken from patients in the Skåne region, southern Sweden, 2006-2019 from the Clinical Microbiology Department database and estimated incidence rates (IR), stratified by age (0-49, 50-64, 65-79, ≥ 80 years), sex, year, and species and described antimicrobial susceptibility for Enterobacterales.ResultsWe identified 944,375 blood culture sets, and 129,274 (13.7%) were positive. After deduplication and removal of contaminants, 54,498 separate BSI episodes remained. In total, 30,003 BSI episodes (55%) occurred in men. The overall IR of BSI was 307/100,000 person-years, with an average annual increase of 3.0%. Persons ≥ 80 years had the highest IR, 1781/100,000 person-years, as well as the largest increase. Escherichia coli (27%) and Staphylococcus aureus (13%) were the most frequent findings. The proportion of Enterobacterales isolates resistant to fluoroquinolones and third generation cephalosporins increased from 8.4% to 13.6%, and 4.9% to 7.3%, (p for trend &lt; 0.001), with the largest increase in the oldest age group.ConclusionWe report among the highest BSI IRs to date worldwide, with a higher proportion among elderly persons and males, including resistant isolates. Given expected demographic changes, these results indicate a possible substantial future BSI burden, for which preventive measures are needed.</p>}},
  author       = {{Ljungquist, Oskar and Blomstergren, Adam and Merkel, Adam and Sunnerhagen, Torgny and Holm, Karin and Torisson, Gustav}},
  issn         = {{1560-7917}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{10}},
  pages        = {{1--10}},
  publisher    = {{European Centre for Disease Prevention and Control (ECDC)}},
  series       = {{Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin}},
  title        = {{Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019 : a population-based study}},
  url          = {{https://lup.lub.lu.se/search/files/140010104/eurosurv_28_10_4.pdf}},
  doi          = {{10.2807/1560-7917.ES.2023.28.10.2200519}},
  volume       = {{28}},
  year         = {{2023}},
}