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Altered structural network organization in cognitively normal individuals with amyloid pathology

Voevodskaya, Olga; Pereira, Joana B.; Volpe, Giovanni; Lindberg, Olof LU ; Stomrud, Erik LU ; van Westen, Danielle LU ; Westman, Eric and Hansson, Oskar LU (2018) In Neurobiology of Aging 64. p.15-24
Abstract

Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels). Structural correlation matrices were constructed based on magnetic resonance imaging cortical thickness data. Despite the fact that no significant regional cortical atrophy was found in... (More)

Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels). Structural correlation matrices were constructed based on magnetic resonance imaging cortical thickness data. Despite the fact that no significant regional cortical atrophy was found in the Aβ-positive group, this group exhibited an altered global network organization, including decreased global efficiency and modularity. At the local level, Aβ-positive individuals displayed fewer and more disorganized modules as well as a loss of hubs. Our findings suggest that changes in network topology occur already at the presymptomatic (preclinical) stage of AD and may precede detectable cortical thinning.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Global efficiency, Graph theory, Hubs, Modularity, Structural covariance networks, β-Amyloid
in
Neurobiology of Aging
volume
64
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:85040051361
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2017.11.014
language
English
LU publication?
yes
id
12d6c331-9c10-4653-8cf3-879968672e00
date added to LUP
2018-01-23 13:46:41
date last changed
2018-01-24 03:00:02
@article{12d6c331-9c10-4653-8cf3-879968672e00,
  abstract     = {<p>Recent findings show that structural network topology is disrupted in Alzheimer's disease (AD), with changes occurring already at the prodromal disease stages. Amyloid accumulation, a hallmark of AD, begins several decades before symptom onset, and its effects on brain connectivity at the earliest disease stages are not fully known. We studied global and local network changes in a large cohort of cognitively healthy individuals (N = 299, Swedish BioFINDER study) with and without amyloid-β (Aβ) pathology (based on cerebrospinal fluid Aβ42/Aβ40 levels). Structural correlation matrices were constructed based on magnetic resonance imaging cortical thickness data. Despite the fact that no significant regional cortical atrophy was found in the Aβ-positive group, this group exhibited an altered global network organization, including decreased global efficiency and modularity. At the local level, Aβ-positive individuals displayed fewer and more disorganized modules as well as a loss of hubs. Our findings suggest that changes in network topology occur already at the presymptomatic (preclinical) stage of AD and may precede detectable cortical thinning.</p>},
  author       = {Voevodskaya, Olga and Pereira, Joana B. and Volpe, Giovanni and Lindberg, Olof and Stomrud, Erik and van Westen, Danielle and Westman, Eric and Hansson, Oskar},
  issn         = {0197-4580},
  keyword      = {Alzheimer's disease,Global efficiency,Graph theory,Hubs,Modularity,Structural covariance networks,β-Amyloid},
  language     = {eng},
  pages        = {15--24},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Altered structural network organization in cognitively normal individuals with amyloid pathology},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.014},
  volume       = {64},
  year         = {2018},
}