Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma.
(2008) In Sarcoma 2008(2009 Feb 2).- Abstract
- Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant subtype. Results. aCGH profiling revealed genetic complexity with multiple gains and losses in all tumors. In an unsupervised hierarchical cluster analysis, similar genomic profiles and close clustering between the first and subsequent STS were... (More)
- Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant subtype. Results. aCGH profiling revealed genetic complexity with multiple gains and losses in all tumors. In an unsupervised hierarchical cluster analysis, similar genomic profiles and close clustering between the first and subsequent STS were identified in 5 cases, suggesting metastatic disease, whereas the tumors from the remaining 8 patients did not cluster and showed only weak pairwise correlation, suggesting development of second primary STS. Discussion. The similarities and dissimilarities identified in the first and second STS suggest that genetic profiles can be used to distinguish soft tissue metastases from second primary STS. The demonstration of genetically different soft tissue sarcomas in the same patient suggests independent tumor origin and serves as a reminder to consider development of second primary STS, which has prognostic and therapeutic implications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1302830
- author
- Fernebro, Josefin
LU
; Carneiro, Ana
LU
; Rydholm, Anders LU ; Domanski, Henryk LU ; Karlsson, Anna F LU ; Borg, Åke LU and Nilbert, Mef LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Sarcoma
- volume
- 2008
- issue
- 2009 Feb 2
- article number
- 431019
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:19197386
- scopus:61449199629
- pmid:19197386
- ISSN
- 1357-714X
- DOI
- 10.1155/2008/431019
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Orthopaedics (Lund) (013028000), Pathology, (Lund) (013030000), Oncology, MV (013035000)
- id
- a97c382b-61c3-4432-92b4-83f8b4429cda (old id 1302830)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19197386?dopt=Abstract
- date added to LUP
- 2016-04-04 09:43:53
- date last changed
- 2022-01-29 19:15:52
@article{a97c382b-61c3-4432-92b4-83f8b4429cda, abstract = {{Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present with malignant fibrous histiocytomas/undifferentiated pleomorphic sarcomas being the predominant subtype. Results. aCGH profiling revealed genetic complexity with multiple gains and losses in all tumors. In an unsupervised hierarchical cluster analysis, similar genomic profiles and close clustering between the first and subsequent STS were identified in 5 cases, suggesting metastatic disease, whereas the tumors from the remaining 8 patients did not cluster and showed only weak pairwise correlation, suggesting development of second primary STS. Discussion. The similarities and dissimilarities identified in the first and second STS suggest that genetic profiles can be used to distinguish soft tissue metastases from second primary STS. The demonstration of genetically different soft tissue sarcomas in the same patient suggests independent tumor origin and serves as a reminder to consider development of second primary STS, which has prognostic and therapeutic implications.}}, author = {{Fernebro, Josefin and Carneiro, Ana and Rydholm, Anders and Domanski, Henryk and Karlsson, Anna F and Borg, Åke and Nilbert, Mef}}, issn = {{1357-714X}}, language = {{eng}}, number = {{2009 Feb 2}}, publisher = {{Hindawi Limited}}, series = {{Sarcoma}}, title = {{Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma.}}, url = {{https://lup.lub.lu.se/search/files/5402577/1363996.pdf}}, doi = {{10.1155/2008/431019}}, volume = {{2008}}, year = {{2008}}, }