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Particle separation using ultrasound can radically reduce embolic load to brain after cardiac surgery.

Bjursten, Henrik LU ; Holm, Cecilia LU ; Lenshof, Andreas LU ; Pettersson, Filip; Johansson, Per and Laurell, Thomas LU (2004) In Annals of Thoracic Surgery 78(5). p.1572-1578
Abstract
Background. Microembolism during cardiopulmonary bypass has been suggested as being the predominant cause of neurocognitive disorders after cardiac surgery. Shed blood, normally retransfused into the patient during cardiopulmonary bypass, is a major source of lipid microemboli in the brain capillaries. A newly developed technique based on acoustic standing-wave separation of particles in fluid in microchannels, with the capacity to remove lipid particles in blood, is presented. Methods. A separator consisting of eight parallel, high-fidelity microfabricated channels was actuated with an ultrasound field to create a standing wave. Three different concentrations of lipid particles (diameter, 0.3 mum) were added to blood samples with... (More)
Background. Microembolism during cardiopulmonary bypass has been suggested as being the predominant cause of neurocognitive disorders after cardiac surgery. Shed blood, normally retransfused into the patient during cardiopulmonary bypass, is a major source of lipid microemboli in the brain capillaries. A newly developed technique based on acoustic standing-wave separation of particles in fluid in microchannels, with the capacity to remove lipid particles in blood, is presented. Methods. A separator consisting of eight parallel, high-fidelity microfabricated channels was actuated with an ultrasound field to create a standing wave. Three different concentrations of lipid particles (diameter, 0.3 mum) were added to blood samples with increasing hematocrits and introduced into the separator channels to separate lipid particles and erythrocytes. Results. The mean separation rates for lipid particles were 81.9% +/- 7.6% and for erythrocytes 79.8% +/- 9.9%, and both were related to the hematocrit level of the incoming blood sample. The procedure was atraumatic and did not cause hemolysis. Conclusions. Particle separation by means of an acoustic standing-wave technique can be used for atraumatic and effective removal of lipid particles from blood, with the possible clinical implication of reducing neurocognitive complications after cardiopulmonary bypass. (C) 2004 by The Society of Thoracic Surgeons. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Annals of Thoracic Surgery
volume
78
issue
5
pages
1572 - 1578
publisher
Elsevier
external identifiers
  • wos:000224950400010
  • scopus:19644367923
ISSN
1552-6259
DOI
10.1016/j.athoracsur.2004.04.071
language
English
LU publication?
yes
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d0147187-f6b5-47cb-b216-153d9084f8fb (old id 131094)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15511433&dopt=Abstract
date added to LUP
2007-07-02 14:07:43
date last changed
2017-08-20 03:28:09
@article{d0147187-f6b5-47cb-b216-153d9084f8fb,
  abstract     = {Background. Microembolism during cardiopulmonary bypass has been suggested as being the predominant cause of neurocognitive disorders after cardiac surgery. Shed blood, normally retransfused into the patient during cardiopulmonary bypass, is a major source of lipid microemboli in the brain capillaries. A newly developed technique based on acoustic standing-wave separation of particles in fluid in microchannels, with the capacity to remove lipid particles in blood, is presented. Methods. A separator consisting of eight parallel, high-fidelity microfabricated channels was actuated with an ultrasound field to create a standing wave. Three different concentrations of lipid particles (diameter, 0.3 mum) were added to blood samples with increasing hematocrits and introduced into the separator channels to separate lipid particles and erythrocytes. Results. The mean separation rates for lipid particles were 81.9% +/- 7.6% and for erythrocytes 79.8% +/- 9.9%, and both were related to the hematocrit level of the incoming blood sample. The procedure was atraumatic and did not cause hemolysis. Conclusions. Particle separation by means of an acoustic standing-wave technique can be used for atraumatic and effective removal of lipid particles from blood, with the possible clinical implication of reducing neurocognitive complications after cardiopulmonary bypass. (C) 2004 by The Society of Thoracic Surgeons.},
  author       = {Bjursten, Henrik and Holm, Cecilia and Lenshof, Andreas and Pettersson, Filip and Johansson, Per and Laurell, Thomas},
  issn         = {1552-6259},
  language     = {eng},
  number       = {5},
  pages        = {1572--1578},
  publisher    = {Elsevier},
  series       = {Annals of Thoracic Surgery},
  title        = {Particle separation using ultrasound can radically reduce embolic load to brain after cardiac surgery.},
  url          = {http://dx.doi.org/10.1016/j.athoracsur.2004.04.071},
  volume       = {78},
  year         = {2004},
}