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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Willer, Cristen J.; Speliotes, Elizabeth K.; Loos, Ruth J. F.; Li, Shengxu; Lindgren, Cecilia M.; Heid, Iris M.; Berndt, Sonja I.; Elliott, Amanda L.; Jackson, Anne U. and Lamina, Claudia, et al. (2009) In Nature Genetics 41(1). p.25-34
Abstract
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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Nature Genetics
volume
41
issue
1
pages
25 - 34
publisher
Nature Publishing Group
external identifiers
  • wos:000262085300013
  • scopus:58149163142
ISSN
1546-1718
DOI
10.1038/ng.287
language
English
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yes
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2491406b-cf62-451a-b8ad-df523798e528 (old id 1312991)
date added to LUP
2009-03-13 11:00:02
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2017-11-26 03:31:20
@article{2491406b-cf62-451a-b8ad-df523798e528,
  abstract     = {Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n &gt; 32,000) and followed up top signals in 14 additional cohorts (n &gt; 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P &lt; 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.},
  author       = {Willer, Cristen J. and Speliotes, Elizabeth K. and Loos, Ruth J. F. and Li, Shengxu and Lindgren, Cecilia M. and Heid, Iris M. and Berndt, Sonja I. and Elliott, Amanda L. and Jackson, Anne U. and Lamina, Claudia and Lettre, Guillaume and Lim, Noha and Lyon, Helen N. and McCarroll, Steven A. and Papadakis, Konstantinos and Qi, Lu and Randall, Joshua C. and Roccasecca, Rosa Maria and Sanna, Serena and Scheet, Paul and Weedon, Michael N. and Wheeler, Eleanor and Zhao, Jing Hua and Jacobs, Leonie C. and Prokopenko, Inga and Soranzo, Nicole and Tanaka, Toshiko and Timpson, Nicholas J. and Almgren, Peter and Bennett, Amanda and Bergman, Richard N. and Bingham, Sheila A. and Bonnycastle, Lori L. and Brown, Morris and Burtt, Noel L. P. and Chines, Peter and Coin, Lachlan and Collins, Francis S. and Connell, John M. and Cooper, Cyrus and Smith, George Davey and Dennison, Elaine M. and Deodhar, Parimal and Elliott, Paul and Erdos, Michael R. and Estrada, Karol and Evans, David M. and Gianniny, Lauren and Gieger, Christian and Gillson, Christopher J. and Guiducci, Candace and Hackett, Rachel and Hadley, David and Hall, Alistair S. and Havulinna, Aki S. and Hebebrand, Johannes and Hofman, Albert and Isomaa, Bo and Jacobs, Kevin B. and Johnson, Toby and Jousilahti, Pekka and Jovanovic, Zorica and Khaw, Kay-Tee and Kraft, Peter and Kuokkanen, Mikko and Kuusisto, Johanna and Laitinen, Jaana and Lakatta, Edward G. and Luan, Jian'an and Luben, Robert N. and Mangino, Massimo and McArdle, Wendy L. and Meitinger, Thomas and Mulas, Antonella and Munroe, Patricia B. and Narisu, Narisu and Ness, Andrew R. and Northstone, Kate and O'Rahilly, Stephen and Purmann, Carolin and Rees, Matthew G. and Ridderstråle, Martin and Ring, Susan M. and Rivadeneira, Fernando and Ruokonen, Aimo and Sandhu, Manjinder S. and Saramies, Jouko and Scott, Laura J. and Scuteri, Angelo and Silander, Kaisa and Sims, Matthew A. and Song, Kijoung and Stephens, Jonathan and Stevens, Suzanne and Stringham, Heather M. and Tung, Y. C. Loraine and Valle, Timo T. and Van Duijn, Cornelia M. and Vimaleswaran, Karani S. and Vollenweider, Peter and Waeber, Gerard and Wallace, Chris and Watanabe, Richard M. and Waterworth, Dawn M. and Watkins, Nicholas and Witteman, Jacqueline C. M. and Zeggini, Eleftheria and Zhai, Guangju and Zillikens, M. Carola and Altshuler, David and Caulfield, Mark J. and Chanock, Stephen J. and Farooqi, I. Sadaf and Ferrucci, Luigi and Guralnik, Jack M. and Hattersley, Andrew T. and Hu, Frank B. and Jarvelin, Marjo-Riitta and Laakso, Markku and Mooser, Vincent and Ong, Ken K. and Ouwehand, Willem H. and Salomaa, Veikko and Samani, Nilesh J. and Spector, Timothy D. and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Uda, Manuela and Uitterlinden, Andre G. and Wareham, Nicholas J. and Deloukas, Panagiotis and Frayling, Timothy M. and Groop, Leif and Hayes, Richard B. and Hunter, David J. and Mohlke, Karen L. and Peltonen, Leena and Schlessinger, David and Strachan, David P. and Wichmann, H-Erich and McCarthy, Mark I. and Boehnke, Michael and Barroso, Ines and Abecasis, Goncalo R. and Hirschhorn, Joel N.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {1},
  pages        = {25--34},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Six new loci associated with body mass index highlight a neuronal influence on body weight regulation},
  url          = {http://dx.doi.org/10.1038/ng.287},
  volume       = {41},
  year         = {2009},
}