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Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100(R).

Silver, Christina LU ; Lindgren, Hanna LU ; Pero, Ronald LU ; Leanderson, Tomas LU and Ivars, Fredrik LU (2005) In International Immunopharmacology 5(1). p.219-229
Abstract
We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA... (More)
We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA inhibited NF-κB activity in exposed cells at similar concentrations. Thus, our present data identify QA as a candidate component for both in vivo and in vitro biological effects of the C-Med 100® extract (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Proliferation, Uncaria tomentosa, Inhibition, NF-κB, Cell survival
in
International Immunopharmacology
volume
5
issue
1
pages
219 - 229
publisher
Elsevier
external identifiers
  • wos:000226615400031
  • pmid:15589483
  • scopus:10344259617
ISSN
1878-1705
DOI
10.1016/j.intimp.2004.09.028
language
English
LU publication?
yes
id
4852424a-ea10-4d47-a9a0-1d4d83c44c1f (old id 132062)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15589483&dopt=Abstract
date added to LUP
2007-07-09 15:57:38
date last changed
2017-07-30 03:42:01
@article{4852424a-ea10-4d47-a9a0-1d4d83c44c1f,
  abstract     = {We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA inhibited NF-κB activity in exposed cells at similar concentrations. Thus, our present data identify QA as a candidate component for both in vivo and in vitro biological effects of the C-Med 100® extract},
  author       = {Silver, Christina and Lindgren, Hanna and Pero, Ronald and Leanderson, Tomas and Ivars, Fredrik},
  issn         = {1878-1705},
  keyword      = {Proliferation,Uncaria tomentosa,Inhibition,NF-κB,Cell survival},
  language     = {eng},
  number       = {1},
  pages        = {219--229},
  publisher    = {Elsevier},
  series       = {International Immunopharmacology},
  title        = {Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100(R).},
  url          = {http://dx.doi.org/10.1016/j.intimp.2004.09.028},
  volume       = {5},
  year         = {2005},
}