Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100(R).
(2005) In International Immunopharmacology 5(1). p.219-229- Abstract
- We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA... (More)
- We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA inhibited NF-κB activity in exposed cells at similar concentrations. Thus, our present data identify QA as a candidate component for both in vivo and in vitro biological effects of the C-Med 100® extract (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/132062
- author
- Silver, Christina LU ; Lindgren, Hanna LU ; Pero, Ronald LU ; Leanderson, Tomas LU and Ivars, Fredrik LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Proliferation, Uncaria tomentosa, Inhibition, NF-κB, Cell survival
- in
- International Immunopharmacology
- volume
- 5
- issue
- 1
- pages
- 219 - 229
- publisher
- Elsevier
- external identifiers
-
- wos:000226615400031
- pmid:15589483
- scopus:10344259617
- pmid:15589483
- ISSN
- 1878-1705
- DOI
- 10.1016/j.intimp.2004.09.028
- language
- English
- LU publication?
- yes
- id
- 4852424a-ea10-4d47-a9a0-1d4d83c44c1f (old id 132062)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15589483&dopt=Abstract
- date added to LUP
- 2016-04-01 12:04:08
- date last changed
- 2022-01-26 22:18:33
@article{4852424a-ea10-4d47-a9a0-1d4d83c44c1f, abstract = {{We have previously reported that the C-Med 100® extract of the plant Uncaria tomentosa induces prolonged lymphocyte half life and hence increased spleen cell number in mice receiving the extract in their drinking water. Further, the extract induces cell proliferation arrest and inhibits activation of the transcriptional regulator nuclear factor κB (NF-κB) in vitro. We now report that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100® exposure. Commercially supplied QA (H+ form) did not, however, inhibit cell proliferation in vitro, while the ammonia-treated QA (QAA) was a potent inhibitor. Both QA and QAA inhibited NF-κB activity in exposed cells at similar concentrations. Thus, our present data identify QA as a candidate component for both in vivo and in vitro biological effects of the C-Med 100® extract}}, author = {{Silver, Christina and Lindgren, Hanna and Pero, Ronald and Leanderson, Tomas and Ivars, Fredrik}}, issn = {{1878-1705}}, keywords = {{Proliferation; Uncaria tomentosa; Inhibition; NF-κB; Cell survival}}, language = {{eng}}, number = {{1}}, pages = {{219--229}}, publisher = {{Elsevier}}, series = {{International Immunopharmacology}}, title = {{Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100(R).}}, url = {{http://dx.doi.org/10.1016/j.intimp.2004.09.028}}, doi = {{10.1016/j.intimp.2004.09.028}}, volume = {{5}}, year = {{2005}}, }