Long-Term Outcome of Percutaneous Coronary Intervention Using Absorb Bioresorbable Scaffold : A SCAAR Study
Saidi-Seresht, Saman ; von Koch, Sacharias LU
; Erlinge, David
LU
; James, Stefan
; Koul, Sasha
LU
and Grimfjärd, Per
(2025)
In Journal of the Society for Cardiovascular Angiography and Interventions
4(9).
- Abstract
Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bioresorbable scaffolds (Abbott) vs contemporary DES, assessing device-related complications and examining potential late benefits. The findings seek to clarify the balance between early risks and long-term advantages of bioresorbable scaffolds in clinical practice. Methods: Complete data from the Swedish Coronary Angiography and Angioplasty... (More)
Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bioresorbable scaffolds (Abbott) vs contemporary DES, assessing device-related complications and examining potential late benefits. The findings seek to clarify the balance between early risks and long-term advantages of bioresorbable scaffolds in clinical practice. Methods: Complete data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) was used to identify all patients receiving Absorb bioresorbable scaffolds or contemporary DES from November 4, 2011 to March 2, 2018. After 1:2 propensity score matching against modern DES, stent thrombosis, target lesion revascularization, in-stent restenosis, myocardial infarction, and all-cause mortality were analyzed. Landmark analyses were performed from 3 years onward. All patients were followed until January 17, 2022. Results: Among 1960/2406 propensity score matched patients/stents (583/802 Absorb bioresorbable scaffolds and 1377/1604 contemporary DES), bioresorbable scaffolds were associated with significantly higher early stent thrombosis, target lesion revascularization, and in-stent restenosis rates. All-cause mortality and myocardial infarction rates did not differ significantly over the entire follow-up. Beyond 3 years, the device-related outcomes converged, while myocardial infarction rates were lower with Absorb bioresorbable scaffolds than contemporary DES. Conclusions: Absorb bioresorbable scaffolds showed inferior early clinical performance compared with contemporary DES, but after 3 years, device-related outcomes were similar, while myocardial infarction rates favored Absorb bioresorbable scaffolds. These findings suggest a complex trade-off between early device-related events and potential long-term benefits of bioresorbable scaffold-mediated vascular restoration.
(Less)
- author
- Saidi-Seresht, Saman
; von Koch, Sacharias
LU
; Erlinge, David
LU
; James, Stefan
; Koul, Sasha
LU
and Grimfjärd, Per
- organization
- publishing date
- 2025-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- absorb, bioresorbable scaffold, percutaneous coronary intervention
- in
- Journal of the Society for Cardiovascular Angiography and Interventions
- volume
- 4
- issue
- 9
- article number
- 103724
- publisher
- Elsevier
- external identifiers
-
- pmid:41040460
- scopus:105012038555
- ISSN
- 2772-9303
- DOI
- 10.1016/j.jscai.2025.103724
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2025 The Author(s)
- id
- 13292561-f471-4088-b045-b1bd02939318
- date added to LUP
- 2026-01-13 13:01:32
- date last changed
- 2026-01-14 03:42:17
@article{13292561-f471-4088-b045-b1bd02939318,
abstract = {{<p>Background: Bioresorbable scaffolds have been associated with inferior outcomes compared to contemporary permanent metallic drug-eluting stents (DES) for percutaneous coronary intervention, particularly within the initial years after implantation; however, their long-term performance remains uncertain. This study aimed to evaluate the long-term outcomes of Swedish patients treated with Absorb bioresorbable scaffolds (Abbott) vs contemporary DES, assessing device-related complications and examining potential late benefits. The findings seek to clarify the balance between early risks and long-term advantages of bioresorbable scaffolds in clinical practice. Methods: Complete data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) was used to identify all patients receiving Absorb bioresorbable scaffolds or contemporary DES from November 4, 2011 to March 2, 2018. After 1:2 propensity score matching against modern DES, stent thrombosis, target lesion revascularization, in-stent restenosis, myocardial infarction, and all-cause mortality were analyzed. Landmark analyses were performed from 3 years onward. All patients were followed until January 17, 2022. Results: Among 1960/2406 propensity score matched patients/stents (583/802 Absorb bioresorbable scaffolds and 1377/1604 contemporary DES), bioresorbable scaffolds were associated with significantly higher early stent thrombosis, target lesion revascularization, and in-stent restenosis rates. All-cause mortality and myocardial infarction rates did not differ significantly over the entire follow-up. Beyond 3 years, the device-related outcomes converged, while myocardial infarction rates were lower with Absorb bioresorbable scaffolds than contemporary DES. Conclusions: Absorb bioresorbable scaffolds showed inferior early clinical performance compared with contemporary DES, but after 3 years, device-related outcomes were similar, while myocardial infarction rates favored Absorb bioresorbable scaffolds. These findings suggest a complex trade-off between early device-related events and potential long-term benefits of bioresorbable scaffold-mediated vascular restoration.</p>}},
author = {{Saidi-Seresht, Saman and von Koch, Sacharias and Erlinge, David and James, Stefan and Koul, Sasha and Grimfjärd, Per}},
issn = {{2772-9303}},
keywords = {{absorb; bioresorbable scaffold; percutaneous coronary intervention}},
language = {{eng}},
number = {{9}},
publisher = {{Elsevier}},
series = {{Journal of the Society for Cardiovascular Angiography and Interventions}},
title = {{Long-Term Outcome of Percutaneous Coronary Intervention Using Absorb Bioresorbable Scaffold : A SCAAR Study}},
url = {{http://dx.doi.org/10.1016/j.jscai.2025.103724}},
doi = {{10.1016/j.jscai.2025.103724}},
volume = {{4}},
year = {{2025}},
}