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Polyneuritis cranialis presenting with anti-GQ1b IgG antibody.

Edvardsson, Bengt LU and Persson, Staffan LU (2009) In Journal of the Neurological Sciences 281. p.125-126
Abstract
A 52-year-old man developed diplopia, a nasal voice, dysphagia, hoarseness and slight bilateral facial palsies. There was no ataxia, areflexia, limb weakness or sensory involvement. Serum anti-GQ1b IgG antibody was present. Treatment with intravenous immunoglobulin started, and the patient responded with a rapid resolution of symptoms. The diagnosis is consistent with polyneuritis cranialis which is considered to be a Guillain-Barre syndrome variant, a forme fruste, but very rare. The diagnosis can be difficult and a thorough investigation is required. Electrophysiological examination, laboratory evaluations, imaging and cerebrospinal fluid examination are often required in the investigations. Cranial neuropathy can be the presentation of... (More)
A 52-year-old man developed diplopia, a nasal voice, dysphagia, hoarseness and slight bilateral facial palsies. There was no ataxia, areflexia, limb weakness or sensory involvement. Serum anti-GQ1b IgG antibody was present. Treatment with intravenous immunoglobulin started, and the patient responded with a rapid resolution of symptoms. The diagnosis is consistent with polyneuritis cranialis which is considered to be a Guillain-Barre syndrome variant, a forme fruste, but very rare. The diagnosis can be difficult and a thorough investigation is required. Electrophysiological examination, laboratory evaluations, imaging and cerebrospinal fluid examination are often required in the investigations. Cranial neuropathy can be the presentation of many disorders. Determination of anti-ganglioside antibodies as anti-GQ1b is valuable to the diagnosis, and shows the association with the Guillain-Barre syndrome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the Neurological Sciences
volume
281
pages
125 - 126
publisher
Elsevier
external identifiers
  • wos:000266736800029
  • pmid:19324375
  • scopus:67349206126
ISSN
1878-5883
DOI
10.1016/j.jns.2009.02.340
language
English
LU publication?
yes
id
9a3fcc76-7ff7-4e06-9659-b11bead8e138 (old id 1367452)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19324375?dopt=Abstract
date added to LUP
2009-04-06 15:35:42
date last changed
2017-01-01 07:29:21
@article{9a3fcc76-7ff7-4e06-9659-b11bead8e138,
  abstract     = {A 52-year-old man developed diplopia, a nasal voice, dysphagia, hoarseness and slight bilateral facial palsies. There was no ataxia, areflexia, limb weakness or sensory involvement. Serum anti-GQ1b IgG antibody was present. Treatment with intravenous immunoglobulin started, and the patient responded with a rapid resolution of symptoms. The diagnosis is consistent with polyneuritis cranialis which is considered to be a Guillain-Barre syndrome variant, a forme fruste, but very rare. The diagnosis can be difficult and a thorough investigation is required. Electrophysiological examination, laboratory evaluations, imaging and cerebrospinal fluid examination are often required in the investigations. Cranial neuropathy can be the presentation of many disorders. Determination of anti-ganglioside antibodies as anti-GQ1b is valuable to the diagnosis, and shows the association with the Guillain-Barre syndrome.},
  author       = {Edvardsson, Bengt and Persson, Staffan},
  issn         = {1878-5883},
  language     = {eng},
  pages        = {125--126},
  publisher    = {Elsevier},
  series       = {Journal of the Neurological Sciences},
  title        = {Polyneuritis cranialis presenting with anti-GQ1b IgG antibody.},
  url          = {http://dx.doi.org/10.1016/j.jns.2009.02.340},
  volume       = {281},
  year         = {2009},
}