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Diffusion-weighted MRI measurements on stroke patients reveal water-exchange mechanisms in sub-acute ischaemic lesions.

Lätt, Jimmy LU ; Nilsson, Markus LU ; van Westen, Danielle LU ; Wirestam, Ronnie LU ; Ståhlberg, Freddy LU and Brockstedt, Sara LU (2009) In NMR in Biomedicine 22(6). p.619-628
Abstract
The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using two different diffusion times (60 and 260 ms). Nine of these patients showed sufficiently large lesions without artefacts to merit further analysis. The signal-versus-b curves from the lesions were plotted and analysed using a two-compartment model including compartmental exchange. To validate the model and to aid the interpretation of the estimated model parameters, Monte Carlo simulations were performed. In eight cases, the... (More)
The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using two different diffusion times (60 and 260 ms). Nine of these patients showed sufficiently large lesions without artefacts to merit further analysis. The signal-versus-b curves from the lesions were plotted and analysed using a two-compartment model including compartmental exchange. To validate the model and to aid the interpretation of the estimated model parameters, Monte Carlo simulations were performed. In eight cases, the plotted signal-versus-b curves, obtained from the lesions, showed a signal-curve split-up when data for the two diffusion times were compared, revealing effects of compartmental water exchange. For one of the patients, parametric maps were generated based on the extracted model parameters. These novel observations suggest that water exchange between different water pools is measurable and thus potentially useful for clinical assessment. The information can improve the understanding of the relationship between the DW-MRI signal intensity and the microstructural properties of the lesions. Copyright (c) 2009 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NMR in Biomedicine
volume
22
issue
6
pages
619 - 628
publisher
John Wiley & Sons
external identifiers
  • wos:000268286500006
  • pmid:19306340
  • scopus:70049104881
ISSN
0952-3480
DOI
10.1002/nbm.1376
language
English
LU publication?
yes
id
472f7eb7-08d1-44e4-b309-209b541c0a79 (old id 1367560)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19306340?dopt=Abstract
http://onlinelibrary.wiley.com/doi/10.1002/nbm.1376/abstract
date added to LUP
2009-04-07 15:31:55
date last changed
2017-08-06 04:44:54
@article{472f7eb7-08d1-44e4-b309-209b541c0a79,
  abstract     = {The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using two different diffusion times (60 and 260 ms). Nine of these patients showed sufficiently large lesions without artefacts to merit further analysis. The signal-versus-b curves from the lesions were plotted and analysed using a two-compartment model including compartmental exchange. To validate the model and to aid the interpretation of the estimated model parameters, Monte Carlo simulations were performed. In eight cases, the plotted signal-versus-b curves, obtained from the lesions, showed a signal-curve split-up when data for the two diffusion times were compared, revealing effects of compartmental water exchange. For one of the patients, parametric maps were generated based on the extracted model parameters. These novel observations suggest that water exchange between different water pools is measurable and thus potentially useful for clinical assessment. The information can improve the understanding of the relationship between the DW-MRI signal intensity and the microstructural properties of the lesions. Copyright (c) 2009 John Wiley & Sons, Ltd.},
  author       = {Lätt, Jimmy and Nilsson, Markus and van Westen, Danielle and Wirestam, Ronnie and Ståhlberg, Freddy and Brockstedt, Sara},
  issn         = {0952-3480},
  language     = {eng},
  number       = {6},
  pages        = {619--628},
  publisher    = {John Wiley & Sons},
  series       = {NMR in Biomedicine},
  title        = {Diffusion-weighted MRI measurements on stroke patients reveal water-exchange mechanisms in sub-acute ischaemic lesions.},
  url          = {http://dx.doi.org/10.1002/nbm.1376},
  volume       = {22},
  year         = {2009},
}