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Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions.

Johansson, Fredrik LU ; Wallman, Lars LU ; Danielsen, Nils LU ; Schouenborg, Jens LU and Kanje, Martin LU (2009) In Acta Biomaterialia 5. p.2230-2237
Abstract
We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineurium-like capsule had formed on each side of the chip. The number of regenerated nerve fibers did not differ on either side of the chip as shown by immunostaining for neurofilaments. However, the capsule that had formed in contact with the chip was significantly thinner on the porous side than on the smooth side. Cellular protrusions had formed on... (More)
We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineurium-like capsule had formed on each side of the chip. The number of regenerated nerve fibers did not differ on either side of the chip as shown by immunostaining for neurofilaments. However, the capsule that had formed in contact with the chip was significantly thinner on the porous side than on the smooth side. Cellular protrusions had formed on the pSi side and the regenerated nerve tissue was found to attach firmly to this surface, while the tissue was hardly attached to the smooth silicon surface. We conclude that a pSi surface, due to its large surface area, diminished inflammatory response and firm adhesion to the tissue, should be a good material for the development of new implantable electronic nerve devices. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Biomaterialia
volume
5
pages
2230 - 2237
publisher
Elsevier
external identifiers
  • wos:000267307900042
  • pmid:19285930
  • scopus:67349233067
ISSN
1878-7568
DOI
10.1016/j.actbio.2009.02.010
language
English
LU publication?
yes
id
22bbaf96-780b-4a9c-b2bd-9e138ed28150 (old id 1367814)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19285930?dopt=Abstract
date added to LUP
2009-04-08 11:45:39
date last changed
2017-09-10 04:43:50
@article{22bbaf96-780b-4a9c-b2bd-9e138ed28150,
  abstract     = {We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineurium-like capsule had formed on each side of the chip. The number of regenerated nerve fibers did not differ on either side of the chip as shown by immunostaining for neurofilaments. However, the capsule that had formed in contact with the chip was significantly thinner on the porous side than on the smooth side. Cellular protrusions had formed on the pSi side and the regenerated nerve tissue was found to attach firmly to this surface, while the tissue was hardly attached to the smooth silicon surface. We conclude that a pSi surface, due to its large surface area, diminished inflammatory response and firm adhesion to the tissue, should be a good material for the development of new implantable electronic nerve devices.},
  author       = {Johansson, Fredrik and Wallman, Lars and Danielsen, Nils and Schouenborg, Jens and Kanje, Martin},
  issn         = {1878-7568},
  language     = {eng},
  pages        = {2230--2237},
  publisher    = {Elsevier},
  series       = {Acta Biomaterialia},
  title        = {Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions.},
  url          = {http://dx.doi.org/10.1016/j.actbio.2009.02.010},
  volume       = {5},
  year         = {2009},
}