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Perfusion weighted MR imaging may differentiate primary CNS-lymphoma from other homogeneously enhancing brain tumors.

Abul-Kasim, Kasim LU ; Maly, Pavel LU ; Anita, Strömbeck; Svensson, Jonas LU and Sundgren, Pia LU (2008) In The Neuroradiology Journal 21(5). p.637-644
Abstract
Primary central nervous system lymphoma (PCNSL), glioblastoma multiforme (GBM) and metastases may be difficult to differentiate based on conventional imaging alone. The aim of this study was to investigate the value of perfusion weighted imaging (PWI) in differentiating homogeneously enhancing PCNSL from homogeneously enhancing GBM and metastases. Seven consecutive patients presenting with homogeneously enhancing intraaxial tumors on MRI were retrospectively analyzed. All seven patients (three immunocompetent patients with PCNSL, three with GBM, and one with cerebral metastases) were examined with identical MR-sequences including PWI. The relative regional Cerebral Blood Volume (rrCBV) and the rrCBV ratio (rrCBVratio) were calculated. In... (More)
Primary central nervous system lymphoma (PCNSL), glioblastoma multiforme (GBM) and metastases may be difficult to differentiate based on conventional imaging alone. The aim of this study was to investigate the value of perfusion weighted imaging (PWI) in differentiating homogeneously enhancing PCNSL from homogeneously enhancing GBM and metastases. Seven consecutive patients presenting with homogeneously enhancing intraaxial tumors on MRI were retrospectively analyzed. All seven patients (three immunocompetent patients with PCNSL, three with GBM, and one with cerebral metastases) were examined with identical MR-sequences including PWI. The relative regional Cerebral Blood Volume (rrCBV) and the rrCBV ratio (rrCBVratio) were calculated. In lymphomas rrCBVratio was 0.93 ± 0.42 (mean ± SD) compared with 7.93 ± 1.44 in GBM and metastases. All lymphomas had rrCBVratio < 1.43 while all GBM and metastases had rrCBVratio > 1.43 (Fischer exact test; p < 0.001). PWI may be a valuable method in differentiating homogenously enhancing PCNSL from GBM and metastases. (Less)
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publication status
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categories
Popular Science
in
The Neuroradiology Journal
volume
21
issue
5
pages
637 - 644
external identifiers
  • scopus:58149293390
language
English
LU publication?
yes
id
2b596573-75f9-43a8-8b0a-650aeeeda13d (old id 1369034)
alternative location
http://www.centauro-online.it/neuroradiology_journal_pdf/NRJ_21_5_Abul-Kasim_1.zip
http://www.researchgate.net/publication/229062170_Perfusion_Weighted_MR_Imaging_may_Differentiate_Primary_CNS_Lymphoma_from_other_Homogeneously_Enhancing_Brain_Tumors/file/79e414ffdd46ca5995.pdf
date added to LUP
2013-08-07 13:46:25
date last changed
2017-02-26 04:33:39
@misc{2b596573-75f9-43a8-8b0a-650aeeeda13d,
  abstract     = {Primary central nervous system lymphoma (PCNSL), glioblastoma multiforme (GBM) and metastases may be difficult to differentiate based on conventional imaging alone. The aim of this study was to investigate the value of perfusion weighted imaging (PWI) in differentiating homogeneously enhancing PCNSL from homogeneously enhancing GBM and metastases. Seven consecutive patients presenting with homogeneously enhancing intraaxial tumors on MRI were retrospectively analyzed. All seven patients (three immunocompetent patients with PCNSL, three with GBM, and one with cerebral metastases) were examined with identical MR-sequences including PWI. The relative regional Cerebral Blood Volume (rrCBV) and the rrCBV ratio (rrCBVratio) were calculated. In lymphomas rrCBVratio was 0.93 ± 0.42 (mean ± SD) compared with 7.93 ± 1.44 in GBM and metastases. All lymphomas had rrCBVratio &lt; 1.43 while all GBM and metastases had rrCBVratio &gt; 1.43 (Fischer exact test; p &lt; 0.001). PWI may be a valuable method in differentiating homogenously enhancing PCNSL from GBM and metastases.},
  author       = {Abul-Kasim, Kasim and Maly, Pavel and Anita, Strömbeck and Svensson, Jonas and Sundgren, Pia},
  language     = {eng},
  number       = {5},
  pages        = {637--644},
  series       = {The Neuroradiology Journal},
  title        = {Perfusion weighted MR imaging may differentiate primary CNS-lymphoma from other homogeneously enhancing brain tumors.},
  volume       = {21},
  year         = {2008},
}