Cancer risk in hospitalised asthma patients
(2009) In British Journal of Cancer 100(5). p.829-833- Abstract
- Asthma is an increasingly common disorder, affecting 5-10% of the population. It involves a dysregulated immune function, which may predispose to subsequent cancer. We examined cancer risk among Swedish subjects who had hospital admission once or multiple times for asthma. An asthma research database was created by identifying asthma patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. A total of 140 425 patients were hospitalised for asthma during 1965-2004, of whom 7421 patients developed cancer, giving an overall standardised incidence ratio (SIR) of 1.36. A significant increase was noted for most sites, with the exception of breast and ovarian cancers and non-Hodgkin's lymphoma and... (More)
- Asthma is an increasingly common disorder, affecting 5-10% of the population. It involves a dysregulated immune function, which may predispose to subsequent cancer. We examined cancer risk among Swedish subjects who had hospital admission once or multiple times for asthma. An asthma research database was created by identifying asthma patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. A total of 140 425 patients were hospitalised for asthma during 1965-2004, of whom 7421 patients developed cancer, giving an overall standardised incidence ratio (SIR) of 1.36. A significant increase was noted for most sites, with the exception of breast and ovarian cancers and non-Hodgkin's lymphoma and myeloma. Patients with multiple hospital admissions showed a high risk, particularly for stomach (SIR 1.70) and colon (SIR 1.99) cancers. A significant decrease was noted for endometrial cancer and skin melanoma. Oesophageal and lung cancers showed high risks throughout the study period, whereas stomach cancer increased towards the end of the period. The relatively stable temporal trends suggest that the asthmatic condition rather than its medication is responsible for the observed associations. British Journal of Cancer (2009) 100, 829-833. doi: 10.1038/sj.bjc.6604890 www.bjcancer.com Published online 27 January 2009 (C) 2009 Cancer Research UK (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1370759
- author
- Ji, J. LU ; Shu, X. LU ; Li, X. LU ; Sundquist, K. LU ; Sundquist, Jan LU and Hemminki, K. LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- national databases, asthma, cancer risk
- in
- British Journal of Cancer
- volume
- 100
- issue
- 5
- pages
- 829 - 833
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000263905900025
- scopus:61749092742
- pmid:19174822
- ISSN
- 1532-1827
- DOI
- 10.1038/sj.bjc.6604890
- language
- English
- LU publication?
- yes
- id
- 1d77a578-146e-47b6-9013-c275005e8783 (old id 1370759)
- date added to LUP
- 2016-04-01 12:22:45
- date last changed
- 2024-01-08 18:25:35
@article{1d77a578-146e-47b6-9013-c275005e8783, abstract = {{Asthma is an increasingly common disorder, affecting 5-10% of the population. It involves a dysregulated immune function, which may predispose to subsequent cancer. We examined cancer risk among Swedish subjects who had hospital admission once or multiple times for asthma. An asthma research database was created by identifying asthma patients from the Swedish Hospital Discharge Register and by linking them with the Cancer Registry. A total of 140 425 patients were hospitalised for asthma during 1965-2004, of whom 7421 patients developed cancer, giving an overall standardised incidence ratio (SIR) of 1.36. A significant increase was noted for most sites, with the exception of breast and ovarian cancers and non-Hodgkin's lymphoma and myeloma. Patients with multiple hospital admissions showed a high risk, particularly for stomach (SIR 1.70) and colon (SIR 1.99) cancers. A significant decrease was noted for endometrial cancer and skin melanoma. Oesophageal and lung cancers showed high risks throughout the study period, whereas stomach cancer increased towards the end of the period. The relatively stable temporal trends suggest that the asthmatic condition rather than its medication is responsible for the observed associations. British Journal of Cancer (2009) 100, 829-833. doi: 10.1038/sj.bjc.6604890 www.bjcancer.com Published online 27 January 2009 (C) 2009 Cancer Research UK}}, author = {{Ji, J. and Shu, X. and Li, X. and Sundquist, K. and Sundquist, Jan and Hemminki, K.}}, issn = {{1532-1827}}, keywords = {{national databases; asthma; cancer risk}}, language = {{eng}}, number = {{5}}, pages = {{829--833}}, publisher = {{Nature Publishing Group}}, series = {{British Journal of Cancer}}, title = {{Cancer risk in hospitalised asthma patients}}, url = {{http://dx.doi.org/10.1038/sj.bjc.6604890}}, doi = {{10.1038/sj.bjc.6604890}}, volume = {{100}}, year = {{2009}}, }