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Increased thrombin generation in women with a history of preeclampsia

Hamad, R. Rafik; Curvers, J.; Berntorp, Erik LU ; Eriksson, M. J. and Bremme, K. (2009) In Thrombosis Research 123(4). p.580-586
Abstract
Introduction: Women with a history of preeclampsia have an increased risk for cardiovascular disease in later Life. We evaluated thrombogenic characteristics of women with a previous history of preeclampsia, expressed in levels of thrombin generation, number of micropartictes and related to menstrual cycle and endothelial function, measured as flow-mediated dilatation. Materials and methods: We included 18 primipara women with a history of preeclampsia and 17 healthy primipara controls, 15 (+/- 3) months after the index pregnancy. Thrombin generation was measured by tissue factor triggered assay, microparticle levels were measured by flow cytometry and the endothelial function was previously examined by measuring flow-mediated dilatation... (More)
Introduction: Women with a history of preeclampsia have an increased risk for cardiovascular disease in later Life. We evaluated thrombogenic characteristics of women with a previous history of preeclampsia, expressed in levels of thrombin generation, number of micropartictes and related to menstrual cycle and endothelial function, measured as flow-mediated dilatation. Materials and methods: We included 18 primipara women with a history of preeclampsia and 17 healthy primipara controls, 15 (+/- 3) months after the index pregnancy. Thrombin generation was measured by tissue factor triggered assay, microparticle levels were measured by flow cytometry and the endothelial function was previously examined by measuring flow-mediated dilatation by high-resotution ultrasound, during follicular and luteal phases of the menstrual cycle. Results: Women with previous preeclampsia produced more total amount of thrombin as calculated from thrombin max, thrombin potential and max slope levels p<0.05, 0.01 and 0.01 respectively. Platelet derived microparticle levels were higher in women with a history of preeclampsia, p=0.07. Flow-mediated dilatation was significantly decreased in comparison to healthy controls (p<0.0001). There were no variation in levels of thrombin, microparticies and flow-mediated dilatation during the menstrual phases. Conclusion: Women with a history of preectampsia show signs of hypercoagutability as indicated by higher thrombin generation and higher platelet derived microparticle levels. Since these women were investigated more than one year after delivery, these results may be indicative of an increased risk of cardiovascular events later in life. (c) 2008 Elsevier Ltd. Alt rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Endothelial, function, Menstrual cycle, Thrombin generation, Microparticles, Preeclampsia
in
Thrombosis Research
volume
123
issue
4
pages
580 - 586
publisher
Elsevier Ltd
external identifiers
  • wos:000263643300003
  • scopus:58649117364
ISSN
1879-2472
DOI
10.1016/j.thromres.2008.03.022
language
English
LU publication?
yes
id
40706a51-eb7a-4464-b4bc-f3f029df6c33 (old id 1370847)
date added to LUP
2009-05-08 14:40:06
date last changed
2017-10-01 03:34:41
@article{40706a51-eb7a-4464-b4bc-f3f029df6c33,
  abstract     = {Introduction: Women with a history of preeclampsia have an increased risk for cardiovascular disease in later Life. We evaluated thrombogenic characteristics of women with a previous history of preeclampsia, expressed in levels of thrombin generation, number of micropartictes and related to menstrual cycle and endothelial function, measured as flow-mediated dilatation. Materials and methods: We included 18 primipara women with a history of preeclampsia and 17 healthy primipara controls, 15 (+/- 3) months after the index pregnancy. Thrombin generation was measured by tissue factor triggered assay, microparticle levels were measured by flow cytometry and the endothelial function was previously examined by measuring flow-mediated dilatation by high-resotution ultrasound, during follicular and luteal phases of the menstrual cycle. Results: Women with previous preeclampsia produced more total amount of thrombin as calculated from thrombin max, thrombin potential and max slope levels p&lt;0.05, 0.01 and 0.01 respectively. Platelet derived microparticle levels were higher in women with a history of preeclampsia, p=0.07. Flow-mediated dilatation was significantly decreased in comparison to healthy controls (p&lt;0.0001). There were no variation in levels of thrombin, microparticies and flow-mediated dilatation during the menstrual phases. Conclusion: Women with a history of preectampsia show signs of hypercoagutability as indicated by higher thrombin generation and higher platelet derived microparticle levels. Since these women were investigated more than one year after delivery, these results may be indicative of an increased risk of cardiovascular events later in life. (c) 2008 Elsevier Ltd. Alt rights reserved.},
  author       = {Hamad, R. Rafik and Curvers, J. and Berntorp, Erik and Eriksson, M. J. and Bremme, K.},
  issn         = {1879-2472},
  keyword      = {Endothelial,function,Menstrual cycle,Thrombin generation,Microparticles,Preeclampsia},
  language     = {eng},
  number       = {4},
  pages        = {580--586},
  publisher    = {Elsevier Ltd},
  series       = {Thrombosis Research},
  title        = {Increased thrombin generation in women with a history of preeclampsia},
  url          = {http://dx.doi.org/10.1016/j.thromres.2008.03.022},
  volume       = {123},
  year         = {2009},
}