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Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain

Ushakova, G. A.; Fomenko, O. Z. and Pierzynowski, Stefan LU (2008) In Neurophysiology 40(4). p.316-318
Abstract
Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
encephalopathy, hepatic, non-alcoholic steatohepatitis, S-100b, astrocytes
in
Neurophysiology
volume
40
issue
4
pages
316 - 318
publisher
Springer
external identifiers
  • wos:000263425200012
  • scopus:60649114645
ISSN
0090-2977
DOI
10.1007/s11062-009-9051-x
language
English
LU publication?
yes
id
0c41f437-afd8-4b31-9bb4-491454c08393 (old id 1375221)
date added to LUP
2009-05-08 15:40:22
date last changed
2017-01-01 06:34:02
@article{0c41f437-afd8-4b31-9bb4-491454c08393,
  abstract     = {Using an experimental model of non-alcoholic (alimentary-induced) steatohepatitis in rats, we found that this pathological condition created by consumption of a special diet for 16 weeks results in a drop in the brain mass (by 22%, on average) and also in decreases in the size and morphological modifications of astrocytes and the level of a calcium-binding protein, S-100b. The latter shifts were greater in the hindbrain, including the cerebellum (34.8%), than in the hemispheres, including the thalamus, hypothalamus, hippocampus, and cortex (18.0%).},
  author       = {Ushakova, G. A. and Fomenko, O. Z. and Pierzynowski, Stefan},
  issn         = {0090-2977},
  keyword      = {encephalopathy,hepatic,non-alcoholic steatohepatitis,S-100b,astrocytes},
  language     = {eng},
  number       = {4},
  pages        = {316--318},
  publisher    = {Springer},
  series       = {Neurophysiology},
  title        = {Non-alcoholic Steatohepatitis Induces a Decrease in the Levels of S-100b in the Rat Brain},
  url          = {http://dx.doi.org/10.1007/s11062-009-9051-x},
  volume       = {40},
  year         = {2008},
}