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Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas

JOHANSSON, BERTIL LU ; MERTENS, FREDRIK LU ; HEIM, SVERRE LU ; KRISTOFFERSSON, ULF LU ; MANDAHL, NILS LU ; OLSSON, HAKAN LU orcid and MITELMAN, FELIX LU orcid (1988) In Hereditas 109(1). p.131-137
Abstract

The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the... (More)

The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Hereditas
volume
109
issue
1
pages
131 - 137
publisher
Wiley-Blackwell
external identifiers
  • scopus:0023778419
  • pmid:3192422
ISSN
0018-0661
DOI
10.1111/j.1601-5223.1988.tb00193.x
language
English
LU publication?
yes
id
1386705e-775a-44a0-945b-85da0b7d77fd
date added to LUP
2018-12-18 13:22:05
date last changed
2024-01-15 10:09:06
@article{1386705e-775a-44a0-945b-85da0b7d77fd,
  abstract     = {{<p>The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p&lt;0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.</p>}},
  author       = {{JOHANSSON, BERTIL and MERTENS, FREDRIK and HEIM, SVERRE and KRISTOFFERSSON, ULF and MANDAHL, NILS and OLSSON, HAKAN and MITELMAN, FELIX}},
  issn         = {{0018-0661}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{131--137}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Hereditas}},
  title        = {{Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas}},
  url          = {{http://dx.doi.org/10.1111/j.1601-5223.1988.tb00193.x}},
  doi          = {{10.1111/j.1601-5223.1988.tb00193.x}},
  volume       = {{109}},
  year         = {{1988}},
}