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Genetic variance in the adiponutrin gene family and childhood obesity.

Johansson, Lovisa LU ; Johansson, Lina LU ; Danielsson, Pernilla; Norgren, Svante; Johansson, Stina; Marcus, Claude and Ridderstråle, Martin LU (2009) In PLoS ONE 4(4).
Abstract
AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. METHODS/RESULTS: Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity... (More)
AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. METHODS/RESULTS: Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p>0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: beta = -0.053, p = 0.016, and rs2072907: beta = -0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. CONCLUSIONS: Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
4
issue
4
publisher
Public Library of Science
external identifiers
  • wos:000265514400013
  • pmid:19390624
  • scopus:65449137548
ISSN
1932-6203
DOI
10.1371/journal.pone.0005327
language
English
LU publication?
yes
id
90c6cbb5-e8e5-4eef-8e07-edfce14166ca (old id 1391874)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19390624?dopt=Abstract
date added to LUP
2009-05-05 14:45:56
date last changed
2017-02-05 04:34:49
@article{90c6cbb5-e8e5-4eef-8e07-edfce14166ca,
  abstract     = {AIM: The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. METHODS/RESULTS: Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p&lt;0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p&gt;0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: beta = -0.053, p = 0.016, and rs2072907: beta = -0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. CONCLUSIONS: Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.},
  articleno    = {e5327},
  author       = {Johansson, Lovisa and Johansson, Lina and Danielsson, Pernilla and Norgren, Svante and Johansson, Stina and Marcus, Claude and Ridderstråle, Martin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {4},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Genetic variance in the adiponutrin gene family and childhood obesity.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0005327},
  volume       = {4},
  year         = {2009},
}