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High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.

Gaber, Alexander LU ; Johansson, M; Stenman, U-H; Hotakainen, K; Pontén, F; Glimelius, B; Bjartell, Anders LU ; Jirström, Karin LU and Birgisson, Hakon LU (2009) In British Journal of Cancer 100. p.1540-1548
Abstract
Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a... (More)
Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a significantly shorter overall survival. In cohort II, in multivariate analysis including age, gender, disease stage, differentiation grade, vascular invasion and carcinoembryonal antigen (CEA), high TATI expression was associated with a significantly decreased overall survival (HR=1.82; 95% CI=1.19-2.79) and disease-free survival (HR=1.56; 95% CI=1.05-2.32) in curatively treated patients. Moreover, there was an increased risk for liver metastasis in both cohorts that remained significant in multivariate analysis in cohort II (HR=2.85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer.British Journal of Cancer advance online publication, 21 April 2009; doi:10.1038/sj.bjc.6605047 www.bjcancer.com. (Less)
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organization
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type
Contribution to journal
publication status
published
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in
British Journal of Cancer
volume
100
pages
1540 - 1548
publisher
Nature Publishing Group
external identifiers
  • wos:000266025100005
  • pmid:19384300
  • scopus:67349251220
ISSN
1532-1827
DOI
10.1038/sj.bjc.6605047
language
English
LU publication?
yes
id
c6cbfb36-cbfc-4db4-9c0f-7257b45f97a0 (old id 1391933)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19384300?dopt=Abstract
date added to LUP
2009-05-05 15:38:28
date last changed
2017-07-23 04:50:37
@article{c6cbfb36-cbfc-4db4-9c0f-7257b45f97a0,
  abstract     = {Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a significantly shorter overall survival. In cohort II, in multivariate analysis including age, gender, disease stage, differentiation grade, vascular invasion and carcinoembryonal antigen (CEA), high TATI expression was associated with a significantly decreased overall survival (HR=1.82; 95% CI=1.19-2.79) and disease-free survival (HR=1.56; 95% CI=1.05-2.32) in curatively treated patients. Moreover, there was an increased risk for liver metastasis in both cohorts that remained significant in multivariate analysis in cohort II (HR=2.85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer.British Journal of Cancer advance online publication, 21 April 2009; doi:10.1038/sj.bjc.6605047 www.bjcancer.com.},
  author       = {Gaber, Alexander and Johansson, M and Stenman, U-H and Hotakainen, K and Pontén, F and Glimelius, B and Bjartell, Anders and Jirström, Karin and Birgisson, Hakon},
  issn         = {1532-1827},
  language     = {eng},
  pages        = {1540--1548},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6605047},
  volume       = {100},
  year         = {2009},
}