High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
Gaber, Alexander LU ; Johansson, M ; Stenman, U-H ; Hotakainen, K ; Pontén, F ; Glimelius, B ; Bjartell, Anders LU ; Jirström, Karin LU
and Birgisson, Hakon
LU
(2009)
In British Journal of Cancer
100.
p.1540-1548
- Abstract
- Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a... (More)
- Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a significantly shorter overall survival. In cohort II, in multivariate analysis including age, gender, disease stage, differentiation grade, vascular invasion and carcinoembryonal antigen (CEA), high TATI expression was associated with a significantly decreased overall survival (HR=1.82; 95% CI=1.19-2.79) and disease-free survival (HR=1.56; 95% CI=1.05-2.32) in curatively treated patients. Moreover, there was an increased risk for liver metastasis in both cohorts that remained significant in multivariate analysis in cohort II (HR=2.85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer.British Journal of Cancer advance online publication, 21 April 2009; doi:10.1038/sj.bjc.6605047 www.bjcancer.com. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1391933
- author
- Gaber, Alexander
LU
; Johansson, M
; Stenman, U-H
; Hotakainen, K
; Pontén, F
; Glimelius, B
; Bjartell, Anders
LU
; Jirström, Karin
LU
and Birgisson, Hakon
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Cancer
- volume
- 100
- pages
- 1540 - 1548
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000266025100005
- pmid:19384300
- scopus:67349251220
- ISSN
- 1532-1827
- DOI
- 10.1038/sj.bjc.6605047
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Urological Cancers (013243420), Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Biotechnology (LTH) (011001037)
- id
- c6cbfb36-cbfc-4db4-9c0f-7257b45f97a0 (old id 1391933)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19384300?dopt=Abstract
- date added to LUP
- 2016-04-04 07:03:22
- date last changed
- 2024-01-29 02:56:28
@article{c6cbfb36-cbfc-4db4-9c0f-7257b45f97a0,
abstract = {{Increased expression of tumour-associated trypsin inhibitor (TATI) in tumour tissue and/or serum has been associated with poor survival in various cancer forms. Moreover, a proinvasive function of TATI has been shown in colon cancer cell lines. In this study, we have examined the prognostic significance of tumour-specific TATI expression in colorectal cancer, assessed by immunohistochemistry (IHC) on tissue microarrays (TMAs) with tumour specimens from two independent patient cohorts. Kaplan-Meier analysis and Cox proportional hazards modelling were used to estimate time to recurrence, disease-free survival and overall survival. In both cohorts, a high (>50% of tumour cells) TATI expression was an independent predictor of a significantly shorter overall survival. In cohort II, in multivariate analysis including age, gender, disease stage, differentiation grade, vascular invasion and carcinoembryonal antigen (CEA), high TATI expression was associated with a significantly decreased overall survival (HR=1.82; 95% CI=1.19-2.79) and disease-free survival (HR=1.56; 95% CI=1.05-2.32) in curatively treated patients. Moreover, there was an increased risk for liver metastasis in both cohorts that remained significant in multivariate analysis in cohort II (HR=2.85; 95% CI=1.43-5.66). In conclusion, high TATI expression is associated with liver metastasis and is an independent predictor of poor prognosis in patients with colorectal cancer.British Journal of Cancer advance online publication, 21 April 2009; doi:10.1038/sj.bjc.6605047 www.bjcancer.com.}},
author = {{Gaber, Alexander and Johansson, M and Stenman, U-H and Hotakainen, K and Pontén, F and Glimelius, B and Bjartell, Anders and Jirström, Karin and Birgisson, Hakon}},
issn = {{1532-1827}},
language = {{eng}},
pages = {{1540--1548}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.}},
url = {{http://dx.doi.org/10.1038/sj.bjc.6605047}},
doi = {{10.1038/sj.bjc.6605047}},
volume = {{100}},
year = {{2009}},
}