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Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease.

Lindvall, Olle LU and Kokaia, Zaal LU (2009) In Trends in Pharmacological Sciences 30(5). p.260-267
Abstract
In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA) neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic tissue have shown that grafted DA neurons reinnervate the striatum, restore striatal DA release and, in some patients, induce major clinical benefit. Stem cells could provide an unlimited source of DA neurons for transplantation. Recent studies demonstrate that cells with properties of mesencephalic DA neurons can be produced from stem cells of different sources including reprogrammed somatic cells. However, as we discuss here, it remains to be shown that these cells can provide efficient functional reinnervation and behavioral recovery in animal PD models.... (More)
In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA) neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic tissue have shown that grafted DA neurons reinnervate the striatum, restore striatal DA release and, in some patients, induce major clinical benefit. Stem cells could provide an unlimited source of DA neurons for transplantation. Recent studies demonstrate that cells with properties of mesencephalic DA neurons can be produced from stem cells of different sources including reprogrammed somatic cells. However, as we discuss here, it remains to be shown that these cells can provide efficient functional reinnervation and behavioral recovery in animal PD models. Moreover, a clinically competitive cell therapy for PD will require better criteria for patient selection, improved functional efficacy of grafts by a tailor-made transplantation procedure providing optimum repair of the patient's DA system and strategies to prevent dyskinesias and tumor formation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Pharmacological Sciences
volume
30
issue
5
pages
260 - 267
publisher
Elsevier
external identifiers
  • WOS:000266400300006
  • PMID:19362379
  • Scopus:65349181409
ISSN
0165-6147
DOI
10.1016/j.tips.2009.03.001
language
English
LU publication?
yes
id
5c95e626-8dcd-4896-b65b-c7250baedd54 (old id 1392179)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19362379?dopt=Abstract
date added to LUP
2009-05-06 13:22:54
date last changed
2017-01-01 07:41:54
@article{5c95e626-8dcd-4896-b65b-c7250baedd54,
  abstract     = {In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA) neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic tissue have shown that grafted DA neurons reinnervate the striatum, restore striatal DA release and, in some patients, induce major clinical benefit. Stem cells could provide an unlimited source of DA neurons for transplantation. Recent studies demonstrate that cells with properties of mesencephalic DA neurons can be produced from stem cells of different sources including reprogrammed somatic cells. However, as we discuss here, it remains to be shown that these cells can provide efficient functional reinnervation and behavioral recovery in animal PD models. Moreover, a clinically competitive cell therapy for PD will require better criteria for patient selection, improved functional efficacy of grafts by a tailor-made transplantation procedure providing optimum repair of the patient's DA system and strategies to prevent dyskinesias and tumor formation.},
  author       = {Lindvall, Olle and Kokaia, Zaal},
  issn         = {0165-6147},
  language     = {eng},
  number       = {5},
  pages        = {260--267},
  publisher    = {Elsevier},
  series       = {Trends in Pharmacological Sciences},
  title        = {Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease.},
  url          = {http://dx.doi.org/10.1016/j.tips.2009.03.001},
  volume       = {30},
  year         = {2009},
}