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Reduced CSF CART in dementia with Lewy bodies.

Schultz, Kristofer LU ; Wiehager, Sara LU ; Nilsson, Karin LU ; Nielsen, Jørgen E; Lindquist, Suzanne G; Hjermind, Lena E; Andersen, Birgitte B; Wallin, Anders; Nilsson, Christer LU and Petersén, Åsa LU (2009) In Neuroscience Letters 453(2). p.104-106
Abstract
Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that... (More)
Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience Letters
volume
453
issue
2
pages
104 - 106
publisher
Elsevier
external identifiers
  • wos:000264691600006
  • pmid:19356602
  • scopus:61449087197
ISSN
0304-3940
DOI
10.1016/j.neulet.2009.02.008
language
English
LU publication?
yes
id
b7bce836-122e-4e08-a348-90f3d2aa0d22 (old id 1392256)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19356602?dopt=Abstract
date added to LUP
2009-05-06 13:59:50
date last changed
2017-04-02 04:14:48
@article{b7bce836-122e-4e08-a348-90f3d2aa0d22,
  abstract     = {Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.},
  author       = {Schultz, Kristofer and Wiehager, Sara and Nilsson, Karin and Nielsen, Jørgen E and Lindquist, Suzanne G and Hjermind, Lena E and Andersen, Birgitte B and Wallin, Anders and Nilsson, Christer and Petersén, Åsa},
  issn         = {0304-3940},
  language     = {eng},
  number       = {2},
  pages        = {104--106},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {Reduced CSF CART in dementia with Lewy bodies.},
  url          = {http://dx.doi.org/10.1016/j.neulet.2009.02.008},
  volume       = {453},
  year         = {2009},
}