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The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.

Papadopoulou, Anastasia LU ; Lynch, Kristian LU ; Shaat, Nael LU ; Nilsson, Anita LU ; Lernmark, Barbro LU ; Berntorp, Kerstin LU ; Ivarsson, S-A; Agardh, Carl-David LU ; Lernmark, Åke LU and , , et al. (2009) In Diabetologia 52. p.1339-1342
Abstract
AIMS/HYPOTHESIS: We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. METHODS: A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. RESULTS: The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not... (More)
AIMS/HYPOTHESIS: We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. METHODS: A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. RESULTS: The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not differ between GDM mothers and controls. In contrast, the low-risk DQB1*0602 allele was less prevalent (OR 0.64, 95% CI = 0.51-0.80, p = 0.0006) in GDM than in control mothers. The difference in DQB1*0602 frequency between GDM mothers and controls remained after multiple logistic regression analysis correcting for maternal age, country of birth, number of pregnancies/siblings and weight gain during pregnancy (OR 0.67, 95% CI 0.51-0.88, p = 0.009). CONCLUSIONS/INTERPRETATION: The negative association between mothers who have non-autoimmune GDM and HLA-DQ*0602 suggest that this allele may protect not only from type 1 diabetes but also from GDM. (Less)
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Contribution to journal
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published
subject
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Diabetologia
volume
52
pages
1339 - 1342
publisher
Springer Verlag
external identifiers
  • wos:000266496000017
  • pmid:19347328
  • scopus:67349261084
ISSN
1432-0428
DOI
10.1007/s00125-009-1351-6
language
English
LU publication?
yes
id
03128adb-ebaf-4164-99a7-2a9731b98ad8 (old id 1392423)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19347328?dopt=Abstract
date added to LUP
2009-05-05 13:37:27
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2017-11-09 15:31:10
@article{03128adb-ebaf-4164-99a7-2a9731b98ad8,
  abstract     = {AIMS/HYPOTHESIS: We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. METHODS: A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. RESULTS: The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not differ between GDM mothers and controls. In contrast, the low-risk DQB1*0602 allele was less prevalent (OR 0.64, 95% CI = 0.51-0.80, p = 0.0006) in GDM than in control mothers. The difference in DQB1*0602 frequency between GDM mothers and controls remained after multiple logistic regression analysis correcting for maternal age, country of birth, number of pregnancies/siblings and weight gain during pregnancy (OR 0.67, 95% CI 0.51-0.88, p = 0.009). CONCLUSIONS/INTERPRETATION: The negative association between mothers who have non-autoimmune GDM and HLA-DQ*0602 suggest that this allele may protect not only from type 1 diabetes but also from GDM.},
  author       = {Papadopoulou, Anastasia and Lynch, Kristian and Shaat, Nael and Nilsson, Anita and Lernmark, Barbro and Berntorp, Kerstin and Ivarsson, S-A and Agardh, Carl-David and Lernmark, Åke and ,  and Carlsson, Annelie},
  issn         = {1432-0428},
  language     = {eng},
  pages        = {1339--1342},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus.},
  url          = {http://dx.doi.org/10.1007/s00125-009-1351-6},
  volume       = {52},
  year         = {2009},
}