Simple Cystatin C-Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan-Barratt Prediction Equations for Children.

Grubb, Anders; Nyman, Ulf; Björk, Jonas; Lindström, Veronica; Rippe, Bengt; Sterner, Gunnar; Christensson, Anders

Simple Cystatin C-Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan-Barratt Prediction Equations for Children.

Mark

Grubb, Anders ^LU

; Nyman, Ulf ^LU ; Björk, Jonas ; Lindström, Veronica ^LU

; Rippe, Bengt ^LU ; Sterner, Gunnar ^LU and Christensson, Anders ^LU (2005) In Clinical Chemistry 51(8). p.1420-1431

Abstract

BACKGROUND: Serum creatinine is the most commonly used marker for estimation of glomerular filtration rate (GFR). To compensate for its drawbacks as a GFR marker, several prediction equations including several parameters are being used, with the Modification of Diet in Renal Disease (MDRD), Schwartz, and Counahan-Barratt equations being the ones most widely accepted for estimation of relative GFR in mL x min(-1) x (1.73 m(2))(-1). The present study analyzes whether these GFR prediction equations for adults and children might be replaced by simple prediction equations based on plasma concentrations of cystatin C.

METHODS: Data from 536 patients (0.3-93 years), consecutively referred for determination of GFR by an invasive gold... (More)

BACKGROUND: Serum creatinine is the most commonly used marker for estimation of glomerular filtration rate (GFR). To compensate for its drawbacks as a GFR marker, several prediction equations including several parameters are being used, with the Modification of Diet in Renal Disease (MDRD), Schwartz, and Counahan-Barratt equations being the ones most widely accepted for estimation of relative GFR in mL x min(-1) x (1.73 m(2))(-1). The present study analyzes whether these GFR prediction equations for adults and children might be replaced by simple prediction equations based on plasma concentrations of cystatin C.

METHODS: Data from 536 patients (0.3-93 years), consecutively referred for determination of GFR by an invasive gold standard procedure, were used for the analysis. Calculations of bias (median percentage of error), correlation (adjusted R(2)), and percentage of estimates within 30% and 50% of measured GFR were used in the comparisons.

RESULTS: A cystatin C-based prediction equation using only concentration in mg/L and a prepubertal factor: GFR [mL x min(-1) x (1.73 m(2))(-1)] = 84.69 x cystatin C (mg/L)(-1.680) x 1.384 (if a child <14 years) assessed GFR equally well or better than the simplified MDRD, the Schwartz, and the Counahan-Barratt prediction equations for the adult (> or =18 years) and juvenile groups of the investigated cohort. Age did not influence the cystatin C-based prediction equation for adults, whereas gender did, but with a factor close to unity (0.948 for females).

CONCLUSION: A GFR prediction equation based solely on cystatin C (in mg/L) and a prepubertal factor might replace the simplified MDRD prediction equation for adults and the Schwartz and Counahan-Barratt prediction equations for children.

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Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/139980

author

Grubb, Anders ^LU

; Nyman, Ulf ^LU ; Björk, Jonas ; Lindström, Veronica ^LU

; Rippe, Bengt ^LU ; Sterner, Gunnar ^LU and Christensson, Anders ^LU

organization

publishing date

2005

type

Contribution to journal

publication status

published

subject

Biochemistry and Molecular Biology

keywords

Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Algorithms, Biomarkers/blood, Child, Child, Preschool, Cystatin C, Cystatins/blood, Female, Glomerular Filtration Rate, Humans, Infant, Infant, Newborn, Kidney/physiopathology, Kidney Diseases/diagnosis, Male, Mathematics, Middle Aged, Predictive Value of Tests, Sex Factors

in

Clinical Chemistry

volume

51

issue

8

pages

1420 - 1431

publisher

American Association for Clinical Chemistry

external identifiers

pmid:15961546
wos:000230766000015
scopus:23044485568
pmid:15961546

ISSN

0009-9147

DOI

10.1373/clinchem.2005.051557

language

English

LU publication?

yes

additional info

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Nephrology (013230024), Division of Clinical Chemistry and Pharmacology (013250300), Division of Occupational and Environmental Medicine (013078001), Medical Radiology Unit (013241410)

id

dde08bdb-dd5a-4723-8f8f-37a691104598 (old id 139980)

alternative location

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15961546&dopt=Abstract

date added to LUP

2016-04-01 12:22:17

date last changed

2023-03-18 17:59:11

@article{dde08bdb-dd5a-4723-8f8f-37a691104598,
  abstract     = {{<p>BACKGROUND: Serum creatinine is the most commonly used marker for estimation of glomerular filtration rate (GFR). To compensate for its drawbacks as a GFR marker, several prediction equations including several parameters are being used, with the Modification of Diet in Renal Disease (MDRD), Schwartz, and Counahan-Barratt equations being the ones most widely accepted for estimation of relative GFR in mL x min(-1) x (1.73 m(2))(-1). The present study analyzes whether these GFR prediction equations for adults and children might be replaced by simple prediction equations based on plasma concentrations of cystatin C.</p><p>METHODS: Data from 536 patients (0.3-93 years), consecutively referred for determination of GFR by an invasive gold standard procedure, were used for the analysis. Calculations of bias (median percentage of error), correlation (adjusted R(2)), and percentage of estimates within 30% and 50% of measured GFR were used in the comparisons.</p><p>RESULTS: A cystatin C-based prediction equation using only concentration in mg/L and a prepubertal factor: GFR [mL x min(-1) x (1.73 m(2))(-1)] = 84.69 x cystatin C (mg/L)(-1.680) x 1.384 (if a child &lt;14 years) assessed GFR equally well or better than the simplified MDRD, the Schwartz, and the Counahan-Barratt prediction equations for the adult (&gt; or =18 years) and juvenile groups of the investigated cohort. Age did not influence the cystatin C-based prediction equation for adults, whereas gender did, but with a factor close to unity (0.948 for females).</p><p>CONCLUSION: A GFR prediction equation based solely on cystatin C (in mg/L) and a prepubertal factor might replace the simplified MDRD prediction equation for adults and the Schwartz and Counahan-Barratt prediction equations for children.</p>}},
  author       = {{Grubb, Anders and Nyman, Ulf and Björk, Jonas and Lindström, Veronica and Rippe, Bengt and Sterner, Gunnar and Christensson, Anders}},
  issn         = {{0009-9147}},
  keywords     = {{Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Algorithms; Biomarkers/blood; Child; Child, Preschool; Cystatin C; Cystatins/blood; Female; Glomerular Filtration Rate; Humans; Infant; Infant, Newborn; Kidney/physiopathology; Kidney Diseases/diagnosis; Male; Mathematics; Middle Aged; Predictive Value of Tests; Sex Factors}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1420--1431}},
  publisher    = {{American Association for Clinical Chemistry}},
  series       = {{Clinical Chemistry}},
  title        = {{Simple Cystatin C-Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan-Barratt Prediction Equations for Children.}},
  url          = {{http://dx.doi.org/10.1373/clinchem.2005.051557}},
  doi          = {{10.1373/clinchem.2005.051557}},
  volume       = {{51}},
  year         = {{2005}},
}

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Simple Cystatin C-Based Prediction Equations for Glomerular Filtration Rate Compared with the Modification of Diet in Renal Disease Prediction Equation for Adults and the Schwartz and the Counahan-Barratt Prediction Equations for Children.