Inflammatory reaction dependence on implant localization in rat soft tissue models
(1997) In Biomaterials 18(14). p.979-987- Abstract
- This study compares two different implantation models in soft tissue in rat abdominal wall with regard to inflammatory reactions. Titanium rods and discs, penetrating or not penetrating the peritoneal wall respectively, were implanted. After 3, 10 or 30 days the distribution of monocytes/macrophages and cytokines (interleukin-1 and transforming growth factor-beta) in the tissue adjacent to the implants was investigated under immunohistochemistry. The macrophage-specific antibody, ED1, was used for the identification of newly recruited macrophages and the ED2 antibody was used for the mature tissue macrophages. After 10 days the non-penetrating implants had a larger number of cells close to the implant than the penetrating implants. The... (More)
- This study compares two different implantation models in soft tissue in rat abdominal wall with regard to inflammatory reactions. Titanium rods and discs, penetrating or not penetrating the peritoneal wall respectively, were implanted. After 3, 10 or 30 days the distribution of monocytes/macrophages and cytokines (interleukin-1 and transforming growth factor-beta) in the tissue adjacent to the implants was investigated under immunohistochemistry. The macrophage-specific antibody, ED1, was used for the identification of newly recruited macrophages and the ED2 antibody was used for the mature tissue macrophages. After 10 days the non-penetrating implants had a larger number of cells close to the implant than the penetrating implants. The opposite was seen after 30 days implantation, with a larger number of cells around the penetrating implants. At all time intervals the penetrating implants had a thicker reactive capsule. The cytokines interleukin-1beta and transforming growth factor-beta could be detected in the reactive tissue adjacent to both types of implants, without obvious differences for the two implant situations. The biocompatibility of a material appears to be influenced by the localization of the implant. In addition, it seems to be of importance to extend the follow-up periods further, as we cannot assume that steady state is reached at 30 days implantation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111334
- author
- Rosengren, Agneta LU ; Danielsen, Nils LU and Bjursten, Lars Magnus LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Titanium, peritoneal implants, macrophages, immunohistochemistry, soft tissue
- in
- Biomaterials
- volume
- 18
- issue
- 14
- pages
- 979 - 987
- publisher
- Elsevier
- external identifiers
-
- pmid:9212193
- scopus:0031193361
- ISSN
- 1878-5905
- DOI
- 10.1016/S0142-9612(97)00012-4
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Bioimplant Research (013242910), Neural Interfaces (013212003)
- id
- 13d73a26-1b94-4dd4-bc09-b69d1842b42e (old id 1111334)
- date added to LUP
- 2016-04-01 11:36:22
- date last changed
- 2022-03-05 03:40:50
@article{13d73a26-1b94-4dd4-bc09-b69d1842b42e,
abstract = {{This study compares two different implantation models in soft tissue in rat abdominal wall with regard to inflammatory reactions. Titanium rods and discs, penetrating or not penetrating the peritoneal wall respectively, were implanted. After 3, 10 or 30 days the distribution of monocytes/macrophages and cytokines (interleukin-1 and transforming growth factor-beta) in the tissue adjacent to the implants was investigated under immunohistochemistry. The macrophage-specific antibody, ED1, was used for the identification of newly recruited macrophages and the ED2 antibody was used for the mature tissue macrophages. After 10 days the non-penetrating implants had a larger number of cells close to the implant than the penetrating implants. The opposite was seen after 30 days implantation, with a larger number of cells around the penetrating implants. At all time intervals the penetrating implants had a thicker reactive capsule. The cytokines interleukin-1beta and transforming growth factor-beta could be detected in the reactive tissue adjacent to both types of implants, without obvious differences for the two implant situations. The biocompatibility of a material appears to be influenced by the localization of the implant. In addition, it seems to be of importance to extend the follow-up periods further, as we cannot assume that steady state is reached at 30 days implantation.}},
author = {{Rosengren, Agneta and Danielsen, Nils and Bjursten, Lars Magnus}},
issn = {{1878-5905}},
keywords = {{Titanium; peritoneal implants; macrophages; immunohistochemistry; soft tissue}},
language = {{eng}},
number = {{14}},
pages = {{979--987}},
publisher = {{Elsevier}},
series = {{Biomaterials}},
title = {{Inflammatory reaction dependence on implant localization in rat soft tissue models}},
url = {{http://dx.doi.org/10.1016/S0142-9612(97)00012-4}},
doi = {{10.1016/S0142-9612(97)00012-4}},
volume = {{18}},
year = {{1997}},
}