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Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture

Gabel, D ; Preusse, D ; Haritz, D ; Grochulla, F ; Haselsberger, K ; Fankhauser, H ; Ceberg, Crister LU orcid ; Peters, H D and Klotz, U (1997) In Acta Neurochirurgica 139(7). p.606-612
Abstract
The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Boron neutron capture therapy, glioma, BSH
in
Acta Neurochirurgica
volume
139
issue
7
pages
606 - 612
publisher
Springer
external identifiers
  • pmid:9265952
  • scopus:0030752312
ISSN
0001-6268
DOI
10.1007/BF01411994
language
English
LU publication?
yes
id
13ef977a-5e03-417b-854d-7363405d0f12 (old id 1112148)
date added to LUP
2016-04-01 17:03:08
date last changed
2025-10-14 13:14:45
@article{13ef977a-5e03-417b-854d-7363405d0f12,
  abstract     = {{The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.1. The data allow the definition of amount of BSH and timing of infusion for a Phase I clinical trial protocol.}},
  author       = {{Gabel, D and Preusse, D and Haritz, D and Grochulla, F and Haselsberger, K and Fankhauser, H and Ceberg, Crister and Peters, H D and Klotz, U}},
  issn         = {{0001-6268}},
  keywords     = {{Boron neutron capture therapy; glioma; BSH}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{606--612}},
  publisher    = {{Springer}},
  series       = {{Acta Neurochirurgica}},
  title        = {{Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture}},
  url          = {{http://dx.doi.org/10.1007/BF01411994}},
  doi          = {{10.1007/BF01411994}},
  volume       = {{139}},
  year         = {{1997}},
}