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Potential for lower absorbed dose in digital mammography: A JAFROC experiment using clinical hybrid images with simulated dose reduction

Timberg, Pontus LU ; Ruschin, Mark LU ; Bath, Magnus ; Hemdal, Bengt LU ; Andersson, Ingvar LU ; Mattsson, Sören LU ; Chakraborty, Dev ; Saunders, Rob ; Samei, Ehsan and Tingberg, Anders LU orcid (2006) Medical Imaging 2006: Image Perception, Observer Performance, and Technology Assessment 6146. p.14614-14614
Abstract
Purpose: To determine how image quality linked to tumor detection is affected by reducing the absorbed dose to 50% and 30% of the clinical levels represented by an average glandular dose (AGD) level of 1.3 mGy for a standard breast according to European guidelines. Materials and methods: 90 normal, unprocessed images were acquired from the screening department using a full-field digital mammography (FFDM) unit Mammomat Novation (Siemens). Into 40 of these, one to three simulated tumors were inserted per image at various positions. These tumors represented irregular-shaped malignant masses. Dose reduction was simulated in all 90 images by adding simulated quantum noise to represent images acquired at 50% and 30% of the original dose,... (More)
Purpose: To determine how image quality linked to tumor detection is affected by reducing the absorbed dose to 50% and 30% of the clinical levels represented by an average glandular dose (AGD) level of 1.3 mGy for a standard breast according to European guidelines. Materials and methods: 90 normal, unprocessed images were acquired from the screening department using a full-field digital mammography (FFDM) unit Mammomat Novation (Siemens). Into 40 of these, one to three simulated tumors were inserted per image at various positions. These tumors represented irregular-shaped malignant masses. Dose reduction was simulated in all 90 images by adding simulated quantum noise to represent images acquired at 50% and 30% of the original dose, resulting in 270 images, which were subsequently processed for final display. Four radiologists participated in a free-response receiver operating characteristics (FROC) study in which they searched for and marked suspicious positions of the masses as well as rated their degree of suspicion of occurrence on a one to four scale. Using the jackknife FROC (JAFROC) method, a score between 0 and 1 (where 1 represents best performance), referred to as a figure-of-merit (FOM), was calculated for each dose level. Results: The FOM was 0.73, 0.70, and 0.68 for the 100%, 50% and 30% dose levels, respectively. Using Analysis of the Variance (ANOVA) to test for statistically significant differences between any two of the three FOMs revealed that they were not statistically distinguishable (p-value of 0.26). Conclusion: For the masses used in this experiment, there was no significant change in detection by increasing quantum noise, thus indicating a potential for dose reduction. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
average glandular dose, FROC, digital mammography, dose reduction, JAFROC, hybrid images
host publication
Medical Imaging 2006: Image Perception, Observer Performance and Technology Assessment
volume
6146
pages
14614 - 14614
publisher
SPIE
conference name
Medical Imaging 2006: Image Perception, Observer Performance, and Technology Assessment
conference location
San Diego, Ca, United States
conference dates
2006-02-12 - 2006-02-14
external identifiers
  • wos:000238040200037
  • scopus:33745137838
ISSN
0277-786X
1996-756X
DOI
10.1117/12.653419
language
English
LU publication?
yes
id
a54b7827-1c68-446b-b07f-d75b85c1d47a (old id 1405947)
date added to LUP
2016-04-01 12:09:31
date last changed
2025-01-02 07:49:13
@inproceedings{a54b7827-1c68-446b-b07f-d75b85c1d47a,
  abstract     = {{Purpose: To determine how image quality linked to tumor detection is affected by reducing the absorbed dose to 50% and 30% of the clinical levels represented by an average glandular dose (AGD) level of 1.3 mGy for a standard breast according to European guidelines. Materials and methods: 90 normal, unprocessed images were acquired from the screening department using a full-field digital mammography (FFDM) unit Mammomat Novation (Siemens). Into 40 of these, one to three simulated tumors were inserted per image at various positions. These tumors represented irregular-shaped malignant masses. Dose reduction was simulated in all 90 images by adding simulated quantum noise to represent images acquired at 50% and 30% of the original dose, resulting in 270 images, which were subsequently processed for final display. Four radiologists participated in a free-response receiver operating characteristics (FROC) study in which they searched for and marked suspicious positions of the masses as well as rated their degree of suspicion of occurrence on a one to four scale. Using the jackknife FROC (JAFROC) method, a score between 0 and 1 (where 1 represents best performance), referred to as a figure-of-merit (FOM), was calculated for each dose level. Results: The FOM was 0.73, 0.70, and 0.68 for the 100%, 50% and 30% dose levels, respectively. Using Analysis of the Variance (ANOVA) to test for statistically significant differences between any two of the three FOMs revealed that they were not statistically distinguishable (p-value of 0.26). Conclusion: For the masses used in this experiment, there was no significant change in detection by increasing quantum noise, thus indicating a potential for dose reduction.}},
  author       = {{Timberg, Pontus and Ruschin, Mark and Bath, Magnus and Hemdal, Bengt and Andersson, Ingvar and Mattsson, Sören and Chakraborty, Dev and Saunders, Rob and Samei, Ehsan and Tingberg, Anders}},
  booktitle    = {{Medical Imaging 2006: Image Perception, Observer Performance and Technology Assessment}},
  issn         = {{0277-786X}},
  keywords     = {{average glandular dose; FROC; digital mammography; dose reduction; JAFROC; hybrid images}},
  language     = {{eng}},
  pages        = {{14614--14614}},
  publisher    = {{SPIE}},
  title        = {{Potential for lower absorbed dose in digital mammography: A JAFROC experiment using clinical hybrid images with simulated dose reduction}},
  url          = {{http://dx.doi.org/10.1117/12.653419}},
  doi          = {{10.1117/12.653419}},
  volume       = {{6146}},
  year         = {{2006}},
}